{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:23:43Z","timestamp":1790468623609,"version":"4.1.0"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":567,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Farming has been associated with rheumatoid arthritis (RA), but the role of pesticides is not known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We examined associations between RA and pesticides or other agricultural exposures among female spouses of licensed pesticide applicators in the Agricultural Health Study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Women were enrolled between 1993 and 1997 and followed through 2010. Cases (n = 275 total, 132 incident), confirmed by a physician or by self-reported use of disease modifying antirheumatic drugs, were compared with noncases (n = 24,018). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models adjusted for age, state, and smoking pack-years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Overall, women with RA were somewhat more likely to have reported lifetime use of any specific pesticide versus no pesticides (OR = 1.4; 95% CI: 1.0, 1.6). Of the 15 pesticides examined, maneb\/mancozeb (OR = 3.3; 95% CI: 1.5, 7.1) and glyphosate (OR = 1.4; 95% CI: 1.0, 2.1) were associated with incident RA compared with no pesticide use. An elevated, but non-statistically significant association with incident RA was seen for DDT (OR = 1.9; 95% CI: 0.97, 3.6). Incident RA was also associated with the application of chemical fertilizers (OR = 1.7; 95% CI: 1.1, 2.7) and cleaning with solvents (OR = 1.6; 95% CI: 1.1, 2.4), but inversely associated with lifetime livestock exposure as a child and adult (OR = 0.48; 95% CI: 0.24, 0.97) compared with no livestock exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our results suggest that specific agricultural pesticides, solvents, and chemical fertilizers may increase the risk of RA in women, while exposures involving animal contact may be protective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Citation:<\/jats:title>\n                    <jats:p>Parks CG, Hoppin JA, De Roos AJ, Costenbader KH, Alavanja MC, Sandler DP. 2016. Rheumatoid arthritis in Agricultural Health Study spouses: associations with pesticides and other farm exposures. Environ Health Perspect 124:1728\u20131734;\u2002http:\/\/dx.doi.org\/10.1289\/EHP129<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp129","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T08:48:23Z","timestamp":1465548503000},"page":"1728-1734","source":"Crossref","is-referenced-by-count":65,"title":["Rheumatoid Arthritis in Agricultural Health Study Spouses: Associations with Pesticides and Other Farm Exposures"],"prefix":"10.1021","volume":"124","author":[{"given":"Christine G.","family":"Parks","sequence":"first","affiliation":[{"name":"Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A.","family":"Hoppin","sequence":"additional","affiliation":[{"name":"Center for Human Health and the Environment, Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneclaire J.","family":"De Roos","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Drexel University School of Public Health, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen H.","family":"Costenbader","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Alavanja","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale P.","family":"Sandler","sequence":"additional","affiliation":[{"name":"Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2016,6,10]]},"reference":[{"key":"2026080314101934500_micit1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1289\/ehp.96104362","article-title":"The Agricultural Health Study.","volume":"104","author":"Alavanja","year":"1996","journal-title":"Environ Health Perspect"},{"issue":"6","key":"2026080314101934500_micit2","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.tiv.2009.06.021","article-title":"Mechanisms of p,p\u2019-DDE-induced apoptosis in human peripheral blood mononuclear cells.","volume":"23","author":"Alegr\u00eda-Torres","year":"2009","journal-title":"Toxicol In Vitro"},{"issue":"4","key":"2026080314101934500_micit3","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/annrheumdis-2012-202302","article-title":"Exposure to ultraviolet-B and risk of developing rheumatoid arthritis among women in the Nurses\u2019 Health Study.","volume":"72","author":"Arkema","year":"2013","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"2026080314101934500_micit4","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/toxsci\/kfr006","article-title":"Exposure to the widely used fungicide mancozeb causes thyroid hormone disruption in rat dams but no behavioral effects in the offspring.","volume":"120","author":"Axelstad","year":"2011","journal-title":"Toxicol Sci"},{"issue":"suppl","key":"2026080314101934500_micit5","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jaut.2005.09.024","article-title":"Infections and autoimmune diseases.","volume":"25","author":"Bach","year":"2005","journal-title":"J Autoimmun"},{"issue":"12","key":"2026080314101934500_micit6","doi-asserted-by":"publisher","first-page":"e51506","DOI":"10.1371\/journal.pone.0051506","article-title":"Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis.","volume":"7","author":"Barrag\u00e1n-Mart\u00ednez","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"2026080314101934500_micit7","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1006\/taap.2002.9377","article-title":"Cytotoxic and endocrine-disrupting potential of atrazine, diazinon, endosulfan, and mancozeb in adrenocortical steroidogenic cells of rainbow trout exposed in vitro.","volume":"180","author":"Bisson","year":"2002","journal-title":"Toxicol Appl Pharmacol"},{"issue":"1","key":"2026080314101934500_micit8","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/BF02975143","article-title":"Effects of mancozeb on the activities of murine peritoneal macrophages in vitro and ex vivo.","volume":"28","author":"Chung","year":"2005","journal-title":"Arch Pharm Res"},{"key":"2026080314101934500_micit9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.tox.2012.10.009","article-title":"Pesticide induced immunotoxicity in humans: a comprehensive review of the existing evidence.","volume":"307","author":"Corsini","year":"2013","journal-title":"Toxicology"},{"issue":"10","key":"2026080314101934500_micit10","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.annepidem.2005.08.001","article-title":"Rheumatoid arthritis among women in the Agricultural Health Study: risk associated with farming activities and exposures.","volume":"15","author":"De Roos","year":"2005","journal-title":"Ann Epidemiol"},{"key":"2026080314101934500_micit11","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1289\/ehp.1408273","article-title":"A review of nonoccupational pathways for pesticide exposure in women living in agricultural areas.","volume":"123","author":"Deziel","year":"2015","journal-title":"Environ Health Perspect"},{"issue":"3","key":"2026080314101934500_micit12","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.tox.2009.06.006","article-title":"Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines.","volume":"262","author":"Gasnier","year":"2009","journal-title":"Toxicology"},{"issue":"10","key":"2026080314101934500_micit13","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1002\/art.22880","article-title":"Systemic autoimmune disease mortality and occupational exposures.","volume":"56","author":"Gold","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"8","key":"2026080314101934500_micit14","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.envres.2011.08.010","article-title":"On multiple comparisons and on the design and interpretation of epidemiological studies of many associations.","volume":"111","author":"Goldberg","year":"2011","journal-title":"Environ Res"},{"issue":"4","key":"2026080314101934500_micit15","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/aje\/kwp404","article-title":"Pesticide use and thyroid disease among women in the Agricultural Health Study.","volume":"171","author":"Goldner","year":"2010","journal-title":"Am J Epidemiol"},{"issue":"1\u20133","key":"2026080314101934500_micit16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0378-4274(01)00489-1","article-title":"Autoimmunity by pesticides: a critical review of the state of the science.","volume":"127","author":"Holsapple","year":"2002","journal-title":"Toxicol Lett"},{"issue":"1","key":"2026080314101934500_micit17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1164\/rccm.200706-821OC","article-title":"Pesticides and atopic and nonatopic asthma among farm women in the Agricultural Health Study.","volume":"177","author":"Hoppin","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"2026080314101934500_micit18","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1002\/art.38124","article-title":"Lipopolysaccharide increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA-1 expression.","volume":"65","author":"Hou","year":"2013","journal-title":"Arthritis Rheum"},{"issue":"3","key":"2026080314101934500_micit19","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00296-013-2865-2","article-title":"Comparison of the 1987 American College of Rheumatology and the 2010 American College of Rheumatology\/European League against Rheumatism criteria for classification of rheumatoid arthritis in the Nurses\u2019 Health Study cohorts.","volume":"34","author":"Kasturi","year":"2014","journal-title":"Rheumatol Int"},{"issue":"4","key":"2026080314101934500_micit20","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1515\/REVEH.2002.17.4.307","article-title":"Environmental risk factors for rheumatoid arthritis.","volume":"17","author":"Khuder","year":"2002","journal-title":"Rev Environ Health"},{"issue":"8","key":"2026080314101934500_micit21","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1097\/01.jom.0000135521.15169.3e","article-title":"Patterns of pesticide use and their determinants among wives of farmer pesticide applicators in the Agricultural Health Study.","volume":"46","author":"Kirrane","year":"2004","journal-title":"J Occup Environ Med"},{"key":"2026080314101934500_micit22","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tox.2014.08.008","article-title":"Glyphosate-rich air samples induce IL-33, TSLP and generate IL-13 dependent airway inflammation.","volume":"325","author":"Kumar","year":"2014","journal-title":"Toxicology"},{"key":"2026080314101934500_micit23","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1289\/ehp.9887","article-title":"Positive associations of serum concentration of polychlorinated biphenyls or organochlorine pesticides with self-reported arthritis, especially rheumatoid type, in women.","volume":"115","author":"Lee","year":"2007","journal-title":"Environ Health Perspect"},{"issue":"5","key":"2026080314101934500_micit24","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/ajim.10131","article-title":"Proportionate mortality of crop and livestock farmers in the United States, 1984\u20131993.","volume":"42","author":"Lee","year":"2002","journal-title":"Am J Ind Med"},{"issue":"1","key":"2026080314101934500_micit25","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00420-014-0933-x","article-title":"The AGRIculture and CANcer (AGRICAN) cohort study: enrollment and causes of death for the 2005\u20132009 period.","volume":"88","author":"Lev\u00eaque-Morlais","year":"2015","journal-title":"Int Arch Occup Environ Health"},{"issue":"6","key":"2026080314101934500_micit26","first-page":"986","article-title":"Socioeconomic and occupational risk factors for rheumatoid arthritis: a nationwide study based on hospitalizations in Sweden.","volume":"35","author":"Li","year":"2008","journal-title":"J Rheumatol"},{"issue":"1","key":"2026080314101934500_micit27","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/15476910490438342","article-title":"Suppression of immune function and susceptibility to infections in humans: association of immune function with clinical disease.","volume":"1","author":"Luebke","year":"2004","journal-title":"J Immunotoxicol"},{"issue":"6","key":"2026080314101934500_micit28","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3109\/03009749409099278","article-title":"Occupation, occupational exposure to chemicals and rheumatological disease. A register based cohort study.","volume":"23","author":"Lundberg","year":"1994","journal-title":"Scand J Rheumatol"},{"issue":"308286","key":"2026080314101934500_micit29","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/308286","article-title":"Proliferation and TH1\/TH2 cytokine production in human peripheral blood mononuclear cells after treatment with cypermethrin and mancozeb in vitro.","volume":"2014","author":"Mandarapu","year":"2014","journal-title":"J Toxicol"},{"issue":"1","key":"2026080314101934500_micit30","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3109\/1547691X.2014.880535","article-title":"In vitro myelotoxic effects of cypermethrin and mancozeb on human hematopoietic progenitor cells.","volume":"12","author":"Mandarapu","year":"2015","journal-title":"J Immunotoxicol"},{"issue":"2","key":"2026080314101934500_micit31","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.envint.2007.07.013","article-title":"Endocrine disrupting pesticides: implications for risk assessment.","volume":"34","author":"McKinlay","year":"2008","journal-title":"Environ Int"},{"issue":"3","key":"2026080314101934500_micit32","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/ajim.4700140311","article-title":"Using multiple cause of death coding in occupational mortality studies.","volume":"14","author":"Milham","year":"1988","journal-title":"Am J Ind Med"},{"issue":"4","key":"2026080314101934500_micit33","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jaut.2012.05.002","article-title":"Epidemiology of environmental exposures and human autoimmune diseases: findings from a National Institute of Environmental Health Sciences Expert Panel Workshop.","volume":"39","author":"Miller","year":"2012","journal-title":"J Autoimmun"},{"issue":"7","key":"2026080314101934500_micit34","first-page":"823","article-title":"Lymphohematopoietic cancers in the United Farm Workers of America (UFW), 1988\u20132001.","volume":"16","author":"Mills","year":"2005","journal-title":"Cancer Causes Control"},{"key":"2026080314101934500_micit35","doi-asserted-by":"publisher","first-page":"680","DOI":"10.3389\/fimmu.2014.00680","article-title":"Innate immune programing by endotoxin and its pathological consequences.","volume":"5","author":"Morris","year":"2015","journal-title":"Front Immunol"},{"issue":"3","key":"2026080314101934500_micit36","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1136\/oem.2003.007971","article-title":"Occupations and exposures in the work environment as determinants for rheumatoid arthritis.","volume":"61","author":"Olsson","year":"2004","journal-title":"Occup Environ Med"},{"issue":"3","key":"2026080314101934500_micit37","doi-asserted-by":"crossref","first-page":"243","DOI":"10.5271\/sjweh.538","article-title":"Occupational determinants for rheumatoid arthritis.","volume":"26","author":"Olsson","year":"2000","journal-title":"Scand J Work Environ Health"},{"issue":"8","key":"2026080314101934500_micit38","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1177\/0961203308089436","article-title":"Childhood agricultural and adult occupational exposures to organic dusts in a population-based case\u2013control study of systemic lupus erythematosus.","volume":"17","author":"Parks","year":"2008","journal-title":"Lupus"},{"issue":"8","key":"2026080314101934500_micit39","doi-asserted-by":"crossref","first-page":"14269","DOI":"10.3390\/ijms150814269","article-title":"Expert panel workshop consensus statement on the role of the environment in the development of autoimmune disease.","volume":"15","author":"Parks","year":"2014","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2026080314101934500_micit40","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/acr.20335","article-title":"Insecticide use and risk of rheumatoid arthritis and systemic lupus erythematosus in the Women\u2019s Health Initiative Observational Study.","volume":"63","author":"Parks","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"4","key":"2026080314101934500_micit41","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1002\/art.10897","article-title":"Prevalence of rheumatoid arthritis in persons 60 years of age and older in the United States: effect of different methods of case classification.","volume":"48","author":"Rasch","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"10","key":"2026080314101934500_micit42","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1136\/ard.60.10.934","article-title":"Comorbidity and lifestyle, reproductive factors, and environmental exposures associated with rheumatoid arthritis.","volume":"60","author":"Reckner Olsson","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"2026080314101934500_micit43","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1289\/ehp.7728","article-title":"Differential effects of glyphosate and roundup on human placental cells and aromatase.","volume":"113","author":"Richard","year":"2005","journal-title":"Environ Health Perspect"},{"issue":"1","key":"2026080314101934500_micit44","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s12016-011-8285-8","article-title":"Hygiene hypothesis and autoimmune diseases.","volume":"42","author":"Rook","year":"2012","journal-title":"Clin Rev Allergy Immunol"},{"issue":"44","key":"2026080314101934500_micit45","doi-asserted-by":"crossref","first-page":"15647","DOI":"10.1073\/pnas.1411512111","article-title":"Long-term relationships among pesticide applications, mobility, and soil erosion in a vineyard watershed.","volume":"111","author":"Sabatier","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"2026080314101934500_micit46","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.3390\/ijerph110404449","article-title":"Non-Hodgkin lymphoma and occupational exposure to agricultural pesticide chemical groups and active ingredients: a systematic review and meta-analysis.","volume":"11","author":"Schinasi","year":"2014","journal-title":"Int J Environ Res Public Health"},{"issue":"5","key":"2026080314101934500_micit47","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1001\/jama.2011.67","article-title":"Receipt of disease-modifying antirheumatic drugs among patients with rheumatoid arthritis in Medicare managed care plans.","volume":"305","author":"Schmajuk","year":"2011","journal-title":"JAMA"},{"issue":"6","key":"2026080314101934500_micit48","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1021\/es4002357","article-title":"Fertilizer-derived uranium and its threat to human health.","volume":"47","author":"Schnug","year":"2013","journal-title":"Environ Sci Technol"},{"issue":"3","key":"2026080314101934500_micit49","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/annhyg\/meq003","article-title":"Quartz exposure in agriculture: literature review and South African survey.","volume":"54","author":"Swanepoel","year":"2010","journal-title":"Ann Occup Hyg"},{"issue":"12","key":"2026080314101934500_micit50","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nri2871","article-title":"Farm living: effects on childhood asthma and allergy.","volume":"10","author":"von Mutius","year":"2010","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"2026080314101934500_micit51","first-page":"811","article-title":"Validation of self-report of rheumatoid arthritis and systemic lupus erythematosus: the Women\u2019s Health Initiative.","volume":"35","author":"Walitt","year":"2008","journal-title":"J Rheumatol"},{"issue":"3","key":"2026080314101934500_micit52","first-page":"546","article-title":"Trends in the use of disease modifying antirheumatic medications in rheumatoid arthritis, 1980\u20131995: results from the National Ambulatory Medical Care Surveys.","volume":"26","author":"Ward","year":"1999","journal-title":"J Rheumatol"},{"issue":"10","key":"2026080314101934500_micit53","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1002\/acr.22312","article-title":"Receipt of glucocorticoid monotherapy among Medicare beneficiaries with rheumatoid arthritis.","volume":"66","author":"Yazdany","year":"2014","journal-title":"Arthritis Care Res (Hoboken)"}],"container-title":["Environmental Health Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/124\/11\/1728\/66375597\/ehp129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/124\/11\/1728\/66375597\/ehp129.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:46:22Z","timestamp":1786628782000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-lookup\/doi\/10.1289\/EHP129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,10]]},"references-count":53,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,6,10]]},"published-print":{"date-parts":[[2016,11,1]]}},"URL":"https:\/\/doi.org\/10.1289\/ehp129","relation":{},"ISSN":["0091-6765","1552-9924"],"issn-type":[{"value":"0091-6765","type":"print"},{"value":"1552-9924","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,10]]}}}