{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:18:37Z","timestamp":1789957117527,"version":"4.0.1"},"reference-count":145,"publisher":"American Chemical Society (ACS)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ Health Perspect"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1289\/ehp14340","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T12:48:29Z","timestamp":1720183709000},"source":"Crossref","is-referenced-by-count":26,"title":["Combined Exposures and Mixtures Research: An Enduring NIEHS Priority"],"prefix":"10.1021","volume":"132","author":[{"given":"Danielle J.","family":"Carlin","sequence":"first","affiliation":[{"name":"Division of Extramural Research and Training, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4497-518X","authenticated-orcid":false,"given":"Cynthia V.","family":"Rider","sequence":"additional","affiliation":[{"name":"Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1409177"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2021.113809"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19106121"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16224417"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.153249"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cotox.2022.100358"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19031378"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107345"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.110-1241268"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2012.10.017"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1206182"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1515\/reveh-2017-0024"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483x(87)90158-2"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1289\/EHP412"},{"key":"e_1_3_2_21_2","unstructured":"NIEHS (National Institute of Environmental Health Sciences). 2021. Exposure Biology and the Exposome. https:\/\/www.niehs.nih.gov\/research\/supported\/exposure\/bio\/index.cfm [accessed 11 July 2023]."},{"key":"e_1_3_2_22_2","unstructured":"NIEHS. 2024. PEGS: Personalized Environment and Genes Study. https:\/\/www.niehs.nih.gov\/research\/atniehs\/labs\/crb\/studies\/pegs [accessed 23 April 2024]."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41370-022-00502-0"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2022.113463"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.0c00213"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-021-00724-z"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1289\/EHP5838"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.1c04455"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cotox.2023.100417"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfz189"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.05.013"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1289\/EHP8525"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2021.105090"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1409247"},{"key":"e_1_3_2_37_2","unstructured":"NIEHS. 2024. Superfund Research Program. https:\/\/www.niehs.nih.gov\/research\/supported\/centers\/srp [accessed 23 April 2024]."},{"key":"e_1_3_2_38_2","unstructured":"NIEHS. 2021. Exposure Biology and the Exposome. https:\/\/www.niehs.nih.gov\/research\/supported\/exposure\/bio [accessed 23 April 2024]."},{"key":"e_1_3_2_39_2","unstructured":"NIEHS. 2024. Environmental Health Disparities and Environmental Justice. https:\/\/www.niehs.nih.gov\/research\/supported\/translational\/justice [accessed 23 April 2024]."},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0456"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay3164"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2021.113768"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107586"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2020.110445"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.estlett.9b00394"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-021-03844-0"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.04.023"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2022.108938"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.2c05911"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.2337\/db21-1093"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000001587"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.159450"},{"key":"e_1_3_2_53_2","unstructured":"HHEAR (Human Health Exposure Analysis Resource). 2023. HHEAR and CHEAR Publications. https:\/\/hhearprogram.org\/chear-publications [accessed 23 April 2024]."},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41370-023-00574-6"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.105545"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106630"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.estlett.1c00648"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxics10070403"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph8062212"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/etc.5571"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2019.5634"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010746"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2020.109275"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1205784"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19073829"},{"key":"e_1_3_2_66_2","volume-title":"Overview of Concepts and Available Guidance related to Integrated Approaches Testing and Assessment (IATA)","author":"OECD (Organisation for Economic Co-operation and Development)","year":"2020","unstructured":"OECD (Organisation for Economic Co-operation and Development). 2020. Overview of Concepts and Available Guidance related to Integrated Approaches Testing and Assessment (IATA). Paris, France: OECD."},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2020.104592"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13066"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2020.104916"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-017-2045-3"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.153024"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1205889"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1289\/EHP547"},{"key":"e_1_3_2_75_2","unstructured":"NIEHS. 2023. Powering Research Through Innovative Methods for Mixtures in Epidemiology (PRIME) Program. https:\/\/www.niehs.nih.gov\/research\/supported\/exposure\/mixtures\/prime_program [accessed 23 April 2024]."},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.9765"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.9099"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1289\/EHP10479"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.2020.1745813"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2020.109529"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19052693"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-21-1140"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-022-00376-2"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41370-022-00451-8"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.152964"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-023-05004-y"},{"key":"e_1_3_2_87_2","volume-title":"Supplementary Guidance for Conducting Health Risk Assessment of Chemical Mixtures","author":"US EPA","year":"2000","unstructured":"US EPA. 2000. Supplementary Guidance for Conducting Health Risk Assessment of Chemical Mixtures. Washington, DC: US EPA."},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1080\/10406630290103960"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19159490"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1289\/EHP7600"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfg124"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/53.2.245"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0901312"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2009.03.030"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kww208"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-017-0232-6"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20102570"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1021\/es405022f"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf300978m"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.03.003"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx5003996"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16030327"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1002\/etc.3507"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1002\/etc.3342"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2021.111893"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2021.130925"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1089\/env.2020.0073"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph182413378"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfab076"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1080\/00032719.2022.2150772"},{"key":"e_1_3_2_113_2","unstructured":"NTP (National Toxicology Program). 2024. NTP Review of Wood Smoke. https:\/\/ntp.niehs.nih.gov\/whatwestudy\/assessments\/cancer\/ongoing\/woodsmoke [accessed 23 April 2024]."},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.145759"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.05.022"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1002\/em.22182"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1177\/0192623317714343"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1080\/01926230701459978"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1177\/0192623313501235"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.04.007"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.08.062"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.12.026"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfab039"},{"key":"e_1_3_2_124_2","doi-asserted-by":"publisher","DOI":"10.1002\/em.22534"},{"key":"e_1_3_2_125_2","doi-asserted-by":"publisher","DOI":"10.1038\/jes.2016.82"},{"key":"e_1_3_2_126_2","doi-asserted-by":"publisher","DOI":"10.1289\/EHP1480"},{"key":"e_1_3_2_127_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djac165"},{"key":"e_1_3_2_128_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33413"},{"key":"e_1_3_2_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.108307"},{"key":"e_1_3_2_130_2","doi-asserted-by":"publisher","DOI":"10.1080\/15287390802608890"},{"key":"e_1_3_2_131_2","doi-asserted-by":"publisher","DOI":"10.1111\/risa.12015"},{"key":"e_1_3_2_132_2","doi-asserted-by":"publisher","DOI":"10.1039\/c6gc01147k"},{"key":"e_1_3_2_133_2","doi-asserted-by":"publisher","DOI":"10.14573\/altex.2006262"},{"key":"e_1_3_2_134_2","unstructured":"US EPA. 2022. Polychlorinated Biphenyls (PCBs). https:\/\/cfpub.epa.gov\/ncea\/iris_drafts\/recordisplay.cfm?deid=354040 [accessed 23 April 2024]."},{"key":"e_1_3_2_135_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgv039"},{"key":"e_1_3_2_136_2","doi-asserted-by":"publisher","DOI":"10.1515\/reveh-2020-0033"},{"key":"e_1_3_2_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106615"},{"key":"e_1_3_2_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111283"},{"key":"e_1_3_2_139_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2021.104981"},{"key":"e_1_3_2_140_2","doi-asserted-by":"publisher","DOI":"10.1289\/EHP4224"},{"key":"e_1_3_2_141_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10115-022-01665-w"},{"key":"e_1_3_2_142_2","unstructured":"NIH (National Institutes of Health). 2020. NOT-OD-21-013: Final NIH Policy for Data Management and Sharing. https:\/\/grants.nih.gov\/grants\/guide\/notice-files\/NOT-OD-21-013.html [accessed 19 July 2023]."},{"key":"e_1_3_2_143_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjhci-2023-100771"},{"key":"e_1_3_2_144_2","doi-asserted-by":"publisher","DOI":"10.1515\/reveh-2019-0089"},{"key":"e_1_3_2_145_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfy278"},{"key":"e_1_3_2_147_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.01.340"},{"key":"e_1_3_2_148_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12302-023-00757-w"},{"key":"e_1_3_2_149_2","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2016.18"},{"key":"e_1_3_2_150_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-019-00229-5"},{"key":"e_1_3_2_151_2","doi-asserted-by":"publisher","DOI":"10.1289\/EHP5878"},{"key":"e_1_3_2_152_2","doi-asserted-by":"publisher","DOI":"10.3389\/ftox.2022.893924"},{"key":"e_1_3_2_153_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003412"},{"key":"e_1_3_2_154_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.158905"},{"key":"e_1_3_2_155_2","doi-asserted-by":"publisher","DOI":"10.1289\/EHP1011"},{"key":"e_1_3_2_156_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1192603"},{"key":"e_1_3_2_157_2","doi-asserted-by":"publisher","DOI":"10.1002\/em.21985"}],"container-title":["Environmental Health Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ehp.niehs.nih.gov\/doi\/pdf\/10.1289\/EHP14340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:49:18Z","timestamp":1786628958000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-lookup\/doi\/10.1289\/EHP14340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":145,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1289\/EHP14340"],"URL":"https:\/\/doi.org\/10.1289\/ehp14340","relation":{},"ISSN":["0091-6765","1552-9924"],"issn-type":[{"value":"0091-6765","type":"print"},{"value":"1552-9924","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"article-number":"075001"}}