{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:05:23Z","timestamp":1791824723811,"version":"4.3.4"},"reference-count":68,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["2020CXJQ01"],"award-info":[{"award-number":["2020CXJQ01"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22206032"],"award-info":[{"award-number":["22206032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41991314"],"award-info":[{"award-number":["41991314"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["22ZR1435600"],"award-info":[{"award-number":["22ZR1435600"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2702903"],"award-info":[{"award-number":["2022YFC2702903"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2705204"],"award-info":[{"award-number":["2022YFC2705204"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"key projects in the three-year plan of Shanghai municipal public health system","doi-asserted-by":"publisher","award":["GWVI-11.1-41"],"award-info":[{"award-number":["GWVI-11.1-41"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>BACKGROUND: Dietary intake, especially foods of animal origin, is an important source of per- and polyfluoroalkyl substance (PFAS) exposure to the general population. However, the distribution of legacy and emerging PFAS in different food categories is unclear, as is their potential health risk for children. OBJECTIVES: To investigate dietary sources of PFAS and evaluate the risk for 7-year-old children in Laizhou Wan, a region with high PFAS exposure in Shandong, China. METHODS: We sampled participants from the Laizhou Wan Birth Cohort study. We administered a dietary questionnaire to the parents of 7-year-old children and measured PFAS compounds in the serum of the children (n = 154) and meat and seafood samples (n = 45). We calculated the Mann\u2013Whitney U test to compare serum PFAS levels between children who frequently consumed a specific type of marine fish or shrimp\/shellfish and those who did not. Children\u2019s dietary PFAS intake was calculated through multiplying food consumption and PFAS concentrations, and health risks were assessed by comparing the intake of PFAS with health-based guideline values. RESULTS: In seafood, perfluorooctanic acid (PFOA) (0.52 ng\/g wet weight (ww)), perfluoro-6-methylheptanesulfonic acid (iso-PFOS) (0.02 ng\/g ww), and 6:2 chlorinated polyfluoroethersulfonic acid (0.06 ng\/g ww) had the highest median concentrations among 10 linear PFAS, 8 branched isomers of PFOA and perfluorooctanesulfonic acid (PFOS), and 3 alternatives, respectively. Particularly, PFOA levels (median, 87.80 ng\/g) in Zoarces slongatus (one type of marine fish) were approximately 10\u2013100 times of those in other seafood species. Children who frequently consumed Z. slongatus had higher serum PFAS levels, especially PFOA, than those who did not. Seafood intake accounted for more than 80% of the total estimated daily intake of the PFAS. The dietary estimated weekly intake values of four PFASs (PFOA, PFOS, perfluorononanoic acid, and perfluorohexanesulfonic acid) for children (7.4 ng\/kg of body weight (bw)\/week) exceeded the tolerable weekly intake (4.4 ng\/kg bw\/week) as recommended by the European Food Safety Authority. CONCLUSION: Seafood was widely contaminated by both legacy PFAS and their alternatives in the Laizhou Wan area. Intake of seafood, especially Z. slongatus, may contribute greatly to PFAS exposure in 7-year-old children. Avoiding the intake of high PFAS-polluted seafood may be an important strategy to protect local children.<\/jats:p>","DOI":"10.1021\/ehp.6c01289","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:04:27Z","timestamp":1785852267000},"page":"558-568","source":"Crossref","is-referenced-by-count":13,"title":["Dietary Exposure to Per- and Polyfluoroalkyl Substances\nand Health Risk Assessment in 7-Year-Old Children in Shandong,\nChina"],"prefix":"10.1021","volume":"134","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine , , ,","place":["Shanghai, China, 200025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yao","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine , , ,","place":["Shanghai, China, 200025"]},{"name":"Shanghai Pulmonary Hospital , , ,","place":["Shanghai, China, 200433"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Shi","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine , , ,","place":["Shanghai, China, 200025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0525-7027","authenticated-orcid":true,"given":"Jingguang","family":"Li","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit (No. 2019RU014), China National Center for Food Safety Risk Assessment , ,","place":["Beijing, China, 100021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Vinturache","sequence":"additional","affiliation":[{"name":"Queen Elizabeth II Hospital , , , ,","place":["Edmonton, Alberta, Canada, T6G 2R3"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghe","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine , , ,","place":["Shanghai, China, 200025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"Lei","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine , , ,","place":["Shanghai, China, 200025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Wang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit (No. 2019RU014), China National Center for Food Safety Risk Assessment , ,","place":["Beijing, China, 100021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Tian","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine , , ,","place":["Shanghai, China, 200025"]},{"name":"Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine , , ,","place":["Shanghai, China, 200092"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gao","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine , , ,","place":["Shanghai, China, 200025"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"2026090306400951900_cit1","doi-asserted-by":"publisher","first-page":"127340","DOI":"10.1016\/j.chemosphere.2020.127340","article-title":"What\nare the effects of PFAS exposure\nat environmentally relevant concentrations?","volume":"258","author":"Sinclair","year":"2020","journal-title":"Chemosphere"},{"key":"2026090306400951900_cit2","doi-asserted-by":"publisher","first-page":"109920","DOI":"10.1016\/j.envres.2020.109920","article-title":"Structure-based virtual\nscreening of perfluoroalkyl and polyfluoroalkyl substances (PFASs)\nas endocrine disruptors of androgen receptor activity using molecular\ndocking and machine learning","volume":"190","author":"Azhagiya Singam","year":"2020","journal-title":"Environ. 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Agric. Food Chem."},{"key":"2026090306400951900_cit45","doi-asserted-by":"publisher","first-page":"130985","DOI":"10.1016\/j.chemosphere.2021.130985","article-title":"Concentrations and\nhuman exposure assessment of per and polyfluoroalkyl substances in\nfarmed marine shellfish in South Africa","volume":"281","author":"Abafe","year":"2021","journal-title":"Chemosphere"},{"key":"2026090306400951900_cit46","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.chemosphere.2018.04.030","article-title":"Risk ranking of environmental\ncontaminants in Xiaoqing River, a heavily polluted river along urbanizing\nBohai Rim","volume":"204","author":"Li","year":"2018","journal-title":"Chemosphere"},{"issue":"14","key":"2026090306400951900_cit47","doi-asserted-by":"publisher","first-page":"9527","DOI":"10.1021\/acs.est.0c08035","article-title":"Spatial and Temporal\nTrends of Perfluoroalkyl Substances\nin Global Ocean and Coastal Waters","volume":"55","author":"Muir","year":"2021","journal-title":"Environ.\nSci. Technol."},{"key":"2026090306400951900_cit48","doi-asserted-by":"publisher","first-page":"138538","DOI":"10.1016\/j.scitotenv.2020.138538","article-title":"Occurrence and risk of chlorinated polyfluoroalkyl\nether sulfonic acids (Cl-PFESAs) in seafood from markets in Beijing,\nChina","volume":"726","author":"Jin","year":"2020","journal-title":"Science of the total environment"},{"issue":"20","key":"2026090306400951900_cit49","doi-asserted-by":"publisher","first-page":"11168","DOI":"10.1021\/jf2007216","article-title":"Perfluorinated\ncompounds in human blood, water, edible\nfreshwater fish, and seafood in China: daily intake and regional differences\nin human exposures","volume":"59","author":"Zhang","year":"2011","journal-title":"J. Agric. Food Chem."},{"issue":"13","key":"2026090306400951900_cit50","doi-asserted-by":"publisher","first-page":"7496","DOI":"10.1021\/jf104943p","article-title":"Levels of perfluorinated compounds in food and dietary\nintake of PFOS and PFOA in the Netherlands","volume":"59","author":"Noorlander","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"2026090306400951900_cit51","unstructured":"U.S. Environmental Protection Agency.\n          .  Drinking Water Health Advisory\nfor Perfluorooctane Sulfonate (PFOS); 2016;\npp 1\u201388. 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