{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:36:10Z","timestamp":1790836570819,"version":"4.1.0"},"reference-count":46,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":584,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Disruption of thyroid homeostasis has been indicated in human studies targeting effects of persistent organic pollutants (POPs). Influence on the maternal thyroid system by POPs is of special interest during pregnancy because such effects could impair infant thyroid homeostasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We investigated the association between POPs and thyroid-stimulating hormone (TSH) and thyroid hormones (THs) in mother and child pairs from the Northern Norway Mother-and-Child Contaminant Cohort Study (MISA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Nineteen POPs and 10 thyroid parameters were analyzed in serum from 391 pregnant women in their second trimester. In addition, TSH concentrations in heel-prick samples from the infants were analyzed by the Norwegian Newborn Screening program. Association studies with a multipollutant approach were performed using multivariate analyses; partial least squares (PLS) regression, hierarchical clustering, and principal component analysis (PCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Several POPs were significantly associated with TSH and THs: a) PFOS was positively associated with TSH; b) PCBs, HCB, and nonachlors were inversely associated with T3, T4, and FT4; and, c) PFDA and PFUnDA were inversely associated with T3 and FT3. After mutual adjustments for the other contaminants, only PFDA and PFUnDA remained significantly associated with T3 and FT3, respectively. Infants born to mothers within the highest TSH quartile had 10% higher mean concentrations of TSH compared with children born to mothers in the lowest TSH quartile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The present results suggest that background exposures to POPs can alter maternal thyroid homeostasis. This research contributes to the understanding of multipollutant exposures using multivariate statistical approaches and highlights the complexity of investigating environmental concentrations and mixtures in regard to maternal and infant thyroid function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Citation:<\/jats:title>\n                    <jats:p>Berg V, N\u00f8st TH, Pettersen RD, Hansen S, Veyhe AS, Jorde R, Odland J\u00d8, Sandanger TM. 2017. Persistent organic pollutants and the association with maternal and infant thyroid homeostasis: a multipollutant assessment. Environ Health Perspect 125:127\u2013133;\u2002http:\/\/dx.doi.org\/10.1289\/EHP152<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp152","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T09:17:55Z","timestamp":1464081475000},"page":"127-133","source":"Crossref","is-referenced-by-count":89,"title":["Persistent Organic Pollutants and the Association with Maternal and Infant Thyroid Homeostasis: A Multipollutant Assessment"],"prefix":"10.1021","volume":"125","author":[{"given":"Vivian","family":"Berg","sequence":"first","affiliation":[{"name":"Diagnostic Clinic, University Hospital of North Norway, Troms\u00f8, Norway"},{"name":"NILU\u2013Norwegian Institute of Air Research, Fram Centre, Troms\u00f8, Norway"},{"name":"Department of Community Medicine, UIT\u2013the Arctic University of Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese Haugdahl","family":"N\u00f8st","sequence":"additional","affiliation":[{"name":"NILU\u2013Norwegian Institute of Air Research, Fram Centre, Troms\u00f8, Norway"},{"name":"Department of Community Medicine, UIT\u2013the Arctic University of Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf Dagfinn","family":"Pettersen","sequence":"additional","affiliation":[{"name":"Norwegian National Unit for Newborn Screening, Women and Children\u2019s Division, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solrunn","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, UIT\u2013the Arctic University of Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Sofia","family":"Veyhe","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, UIT\u2013the Arctic University of Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Jorde","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, UIT\u2013the Arctic University of Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon \u00d8yvind","family":"Odland","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, UIT\u2013the Arctic University of Norway, Troms\u00f8, Norway"},{"name":"Department of Public Health, University of Pretoria, Pretoria, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torkjel Manning","family":"Sandanger","sequence":"additional","affiliation":[{"name":"NILU\u2013Norwegian Institute of Air Research, Fram Centre, Troms\u00f8, Norway"},{"name":"Department of Community Medicine, UIT\u2013the Arctic University of Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2016,5,24]]},"reference":[{"issue":"8","key":"2026080314110070600_micit1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1210\/jc.2007-0141","article-title":"Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society Clinical Practice Guideline.","volume":"92","author":"Abalovich","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"2026080314110070600_micit2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0009-8981(89)90054-5","article-title":"The estimation of total serum lipids by a completely enzymatic \u2018summation\u2019 method.","volume":"184","author":"Akins","year":"1989","journal-title":"Clin Chim Acta"},{"key":"2026080314110070600_micit3","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1089\/thy.2008.0341","article-title":"Delayed neurobehavioral development in children born to pregnant women with mild hypothyroxinemia during the first month of gestation: the importance of early iodine supplementation.","volume":"19","author":"Berbel","year":"2009","journal-title":"Thyroid"},{"key":"2026080314110070600_micit4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.envint.2015.01.007","article-title":"Assessing the relationship between perfluoroalkyl substances, thyroid hormones and binding proteins in pregnant women; a longitudinal mixed effects approach.","volume":"77","author":"Berg","year":"2015","journal-title":"Environ Int"},{"key":"2026080314110070600_micit5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.envint.2014.04.010","article-title":"Maternal serum concentrations of per- and polyfluoroalkyl substances and their predictors in years with reduced production and use.","volume":"69","author":"Berg","year":"2014","journal-title":"Environ Int"},{"key":"2026080314110070600_micit6","first-page":"627","article-title":"Pituitary, adrenal, and thyroid function. 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