{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:59:05Z","timestamp":1788404345579,"version":"build-2803163510"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":541,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>It has been widely demonstrated that air pollution can affect human health and that certain pollutant gases lead to adverse obstetric outcomes, such as preeclampsia and fetal growth restriction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We evaluated the influence of individual maternal exposure to air pollution on placental volume and vascularization evaluated in the first trimester of pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a cross-sectional study on low-risk pregnant women living in S\u00e3o Paulo, Brazil. The women carried passive personal NO2 and O3 monitors in the week preceding evaluation. We employed the virtual organ computer-aided analysis (VOCAL) technique using three-dimensional power Doppler ultrasound to evaluate placental volume and placental vascular indexes [vascularization index (VI), flow index (FI), and vascularization flow index (VFI)]. We analyzed the influence of pollutant levels on log-transformed placental vascularization and volume using multiple regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We evaluated 229 patients. Increased NO2 levels had a significant negative association with log of VI (p = 0.020 and beta = \u20130.153) and VFI (p = 0.024 and beta = \u20130.151). NO2 and O3 had no influence on the log of placental volume or FI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>NO2, an estimator of primary air pollutants, was significantly associated with diminished VI and VFI in the first trimester of pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Citation:<\/jats:title>\n                    <jats:p>Hettfleisch K, Bernardes LS, Carvalho MA, Pastro LD, Vieira SE, Saldiva SR, Saldiva P, Francisco RP. 2017. Short-term exposure to urban air pollution and influences on placental vascularization indexes. Environ Health Perspect 125:753\u2013759;\u2002http:\/\/dx.doi.org\/10.1289\/EHP300<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp300","type":"journal-article","created":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T14:02:40Z","timestamp":1467813760000},"page":"753-759","source":"Crossref","is-referenced-by-count":62,"title":["Short-Term Exposure to Urban Air Pollution and Influences on Placental Vascularization Indexes"],"prefix":"10.1021","volume":"125","author":[{"given":"Karen","family":"Hettfleisch","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisandra Stein","family":"Bernardes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Azevedo","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Duzolina Manfr\u00e9","family":"Pastro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Elisabete","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, S\u00e3o Paulo University Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia R. 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