{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:07:12Z","timestamp":1792084032991,"version":"4.4.0"},"reference-count":59,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Prenatal exposure to air pollution has been associated with childhood respiratory disease and other adverse outcomes. Epigenetics is a suggested link between exposures and health outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We aimed to investigate associations between prenatal exposure to particulate matter (PM) with diameter &amp;lt;10 (PM10) or &amp;lt;2.5\u03bcm (PM2.5) and DNA methylation in newborns and children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We meta-analyzed associations between exposure to PM10 (n=1,949) and PM2.5 (n=1,551) at maternal home addresses during pregnancy and newborn DNA methylation assessed by Illumina Infinium HumanMethylation450K BeadChip in nine European and American studies, with replication in 688 independent newborns and look-up analyses in 2,118 older children. We used two approaches, one focusing on single cytosine-phosphate-guanine (CpG) sites and another on differentially methylated regions (DMRs). We also related PM exposures to blood mRNA expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Six CpGs were significantly associated [false discovery rate (FDR) &amp;lt;0.05] with prenatal PM10 and 14 with PM2.5 exposure. Two of the PM10-related CpGs mapped to FAM13A (cg00905156) and NOTCH4 (cg06849931) previously associated with lung function and asthma. Although these associations did not replicate in the smaller newborn sample, both CpGs were significant (p&amp;lt;0.05) in 7- to 9-y-olds. For cg06849931, however, the direction of the association was inconsistent. Concurrent PM10 exposure was associated with a significantly higher NOTCH4 expression at age 16 y. We also identified several DMRs associated with either prenatal PM10 and or PM2.5 exposure, of which two PM10-related DMRs, including H19 and MARCH11, replicated in newborns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Several differentially methylated CpGs and DMRs associated with prenatal PM exposure were identified in newborns, with annotation to genes previously implicated in lung-related outcomes. https:\/\/doi.org\/10.1289\/EHP4522<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp4522","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T07:38:31Z","timestamp":1559288311000},"source":"Crossref","is-referenced-by-count":155,"title":["Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis"],"prefix":"10.1021","volume":"127","author":[{"given":"Olena","family":"Gruzieva","sequence":"first","affiliation":[{"name":"Karolinska Institutet Institute of Environmental Medicine, , Stockholm,","place":["Sweden"]},{"name":"Stockholm County Council Centre for Occupational and Environmental Medicine, , Stockholm,","place":["Sweden"]},{"name":"Universitat Pompeu Fabra (UPF) , Barcelona,","place":["Spain"]},{"name":"University Medical Center Rotterdam Department of Epidemiology, Erasmus MC, , Rotterdam,","place":["Netherlands"]},{"name":"University of Helsinki Folkh\u00e4lsan Institute of Genetics, and Molecular Neurology Research Program, , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Jian","family":"Xu","sequence":"additional","affiliation":[{"name":"University Medical Center Groningen, University of Groningen Groningen Research Institute for Asthma and COPD, ,","place":["Netherlands"]},{"name":"University Medical Center Groningen, Beatrix Children's Hospital, University of Groningen Department of Pediatric Pulmonology and Pediatric Allergology, ,","place":["Netherlands"]},{"name":"University Medical Center Groningen, University of Groningen Department of Genetics, ,","place":["Netherlands"]},{"name":"Universitat Pompeu Fabra (UPF) , Barcelona,","place":["Spain"]},{"name":"University Medical Center Rotterdam Department of Epidemiology, Erasmus MC, , Rotterdam,","place":["Netherlands"]},{"name":"University of Helsinki Folkh\u00e4lsan Institute of Genetics, and Molecular Neurology Research Program, , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Yousefi","sequence":"additional","affiliation":[{"name":"University of Bristol MRC Integrative Epidemiology Unit, , Bristol,","place":["UK"]},{"name":"University of Bristol Population Health Sciences, Bristol Medical School, , Bristol,","place":["UK"]},{"name":"Universitat Pompeu Fabra (UPF) , Barcelona,","place":["Spain"]},{"name":"University Medical Center Rotterdam Department of Epidemiology, Erasmus MC, , Rotterdam,","place":["Netherlands"]},{"name":"University of Helsinki Folkh\u00e4lsan Institute of Genetics, and Molecular Neurology Research Program, , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Relton","sequence":"additional","affiliation":[{"name":"University of Bristol MRC Integrative Epidemiology Unit, , Bristol,","place":["UK"]},{"name":"University of Bristol Population Health Sciences, Bristol Medical School, , Bristol,","place":["UK"]},{"name":"Universitat Pompeu Fabra (UPF) , Barcelona,","place":["Spain"]},{"name":"University Medical Center Rotterdam Department of Epidemiology, Erasmus MC, , Rotterdam,","place":["Netherlands"]},{"name":"University of Helsinki Folkh\u00e4lsan Institute of Genetics, and Molecular Neurology Research Program, , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon Kebede","family":"Merid","sequence":"additional","affiliation":[{"name":"Karolinska Institutet Institute of Environmental Medicine, , Stockholm,","place":["Sweden"]},{"name":"Universitat Pompeu Fabra (UPF) , Barcelona,","place":["Spain"]},{"name":"University Medical Center Rotterdam Department of Epidemiology, Erasmus MC, , Rotterdam,","place":["Netherlands"]},{"name":"University of Helsinki Folkh\u00e4lsan Institute of Genetics, and Molecular Neurology Research Program, , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie V.","family":"Breton","sequence":"additional","affiliation":[{"name":"University of Southern California Los Angeles Department of Preventive Medicine, , Los Angeles, California,","place":["USA"]},{"name":"Universitat Pompeu Fabra (UPF) , Barcelona,","place":["Spain"]},{"name":"University Medical Center Rotterdam Department of Epidemiology, Erasmus MC, , Rotterdam,","place":["Netherlands"]},{"name":"University of Helsinki Folkh\u00e4lsan Institute of Genetics, and Molecular Neurology Research Program, , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Gao","sequence":"additional","affiliation":[{"name":"University of Southern California Los Angeles Department of Preventive Medicine, , Los Angeles, California,","place":["USA"]},{"name":"Universitat Pompeu Fabra (UPF) , Barcelona,","place":["Spain"]},{"name":"University Medical Center Rotterdam Department of Epidemiology, Erasmus MC, , Rotterdam,","place":["Netherlands"]},{"name":"University of Helsinki Folkh\u00e4lsan Institute of Genetics, and Molecular Neurology Research Program, , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather E.","family":"Volk","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School of 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Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathana\u00ebl","family":"Lemonnier","sequence":"additional","affiliation":[{"name":"CNRS-ENS-UCBL, Universit\u00e9 de Lyon European Institute for Systems Biology and Medicine (EISBM), , Lyon,","place":["France"]},{"name":"UGA-Institut national de la sant\u00e9 et de la recherch\u00e9 m\u00e9dicale (Inserm) Institute for Advanced Biosciences, , La Tronche,","place":["France"]},{"name":"Universitat Pompeu Fabra (UPF) , Barcelona,","place":["Spain"]},{"name":"University Medical Center Rotterdam Department of Epidemiology, Erasmus MC, , Rotterdam,","place":["Netherlands"]},{"name":"University of Helsinki Folkh\u00e4lsan Institute of Genetics, and Molecular Neurology Research Program, , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Plusquin","sequence":"additional","affiliation":[{"name":"Hasselt University Centre for 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Leuven,","place":["Belgium"]},{"name":"Universitat Pompeu Fabra (UPF) , Barcelona,","place":["Spain"]},{"name":"University Medical Center Rotterdam Department of Epidemiology, Erasmus MC, , Rotterdam,","place":["Netherlands"]},{"name":"University of Helsinki Folkh\u00e4lsan Institute of Genetics, and Molecular Neurology Research Program, , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costanza","family":"Pizzi","sequence":"additional","affiliation":[{"name":"University of Turin and CPO-Piemonte Cancer Epidemiology Unit, Department of Medical Sciences, , Turin,","place":["Italy"]},{"name":"Universitat Pompeu Fabra (UPF) , Barcelona,","place":["Spain"]},{"name":"University Medical Center Rotterdam Department of Epidemiology, Erasmus MC, , Rotterdam,","place":["Netherlands"]},{"name":"University of Helsinki Folkh\u00e4lsan Institute of Genetics, and Molecular Neurology Research Program, , 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