{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:10:54Z","timestamp":1792206654273,"version":"4.4.0"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":541,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Numerous studies have identified detectable levels of neonicotinoids (neonics) in the environment, adverse effects of neonics in many species, including mammals, and pathways through which human exposure to neonics could occur, yet little is known about the human health effects of neonic exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>In this systematic review, we sought to identify human population studies on the health effects of neonics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Studies published in English between 2005 and 2015 were searched using PubMed, Scopus, and Web of Science databases. No restrictions were placed on the type of health outcome assessed. Risk of bias was assessed using guidance developed by the National Toxicology Program\u2019s Office of Health Assessment and Translation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Eight studies investigating the human health effects of exposure to neonics were identified. Four examined acute exposure: Three neonic poisoning studies reported two fatalities (n = 1,280 cases) and an occupational exposure study of 19 forestry workers reported no adverse effects. Four general population studies reported associations between chronic neonic exposure and adverse developmental or neurological outcomes, including tetralogy of Fallot (AOR 2.4, 95% CI: 1.1, 5.4), anencephaly (AOR 2.9, 95% CI: 1.0, 8.2), autism spectrum disorder [AOR 1.3, 95% credible interval (CrI): 0.78, 2.2], and a symptom cluster including memory loss and finger tremor (OR 14, 95% CI: 3.5, 57). Reported odds ratios were based on exposed compared to unexposed groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The studies conducted to date were limited in number with suggestive but methodologically weak findings related to chronic exposure. Given the wide-scale use of neonics, more studies are needed to fully understand their effects on human health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Citation:<\/jats:title>\n                    <jats:p>Cimino AM, Boyles AL, Thayer KA, Perry MJ. 2017. Effects of neonicotinoid pesticide exposure on human health: a systematic review. Environ Health Perspect 125:155\u2013162; http:\/\/dx.doi.org\/10.1289\/EHP515<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp515","type":"journal-article","created":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T08:46:50Z","timestamp":1467794810000},"page":"155-162","source":"Crossref","is-referenced-by-count":499,"title":["Effects of Neonicotinoid Pesticide Exposure on Human Health: A Systematic Review"],"prefix":"10.1021","volume":"125","author":[{"given":"Andria M.","family":"Cimino","sequence":"first","affiliation":[{"name":"Department of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abee L.","family":"Boyles","sequence":"additional","affiliation":[{"name":"Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina A.","family":"Thayer","sequence":"additional","affiliation":[{"name":"Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa J.","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2016,7,6]]},"reference":[{"issue":"2","key":"2026080506043446300_micit1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/15287390701613140","article-title":"Imidacloprid induces neurobehavioral deficits and increases expression of glial fibrillary acidic protein in the motor cortex and hippocampus in offspring rats following in utero exposure.","volume":"71","author":"Abou-Donia","year":"2008","journal-title":"J Toxicol Environ Health A"},{"key":"2026080506043446300_micit2","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.scitotenv.2014.09.090","article-title":"Neonicotinoids in the Canadian aquatic environment: a literature review on current use products with a focus on fate, exposure, and biological effects.","volume":"505","author":"Anderson","year":"2015","journal-title":"Sci Total Environ"},{"issue":"1","key":"2026080506043446300_micit3","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s11356-014-3332-7","article-title":"Environmental fate and exposure; neonicotinoids and fipronil.","volume":"22","author":"Bonmatin","year":"2015","journal-title":"Environ Sci Pollut Res Int"},{"key":"2026080506043446300_micit4","doi-asserted-by":"publisher","first-page":"612647","DOI":"10.1155\/2012\/612647","article-title":"Evaluation of genotoxic and cytotoxic effects in human peripheral blood lymphocytes exposed in vitro to neonicotinoid insecticides news.","volume":"2012","author":"Calder\u00f3n-Segura","year":"2012","journal-title":"J Toxicol"},{"issue":"27","key":"2026080506043446300_micit5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jes.2014.07.018","article-title":"Assessment of potential dermal and inhalation exposure of workers to the insecticide imidacloprid using whole-body dosimetry in China.","volume":"1","author":"Cao","year":"2015","journal-title":"J Environ Sci (China)"},{"key":"2026080506043446300_micit6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.envres.2014.08.030","article-title":"Residential agricultural pesticide exposures and risk of selected congenital heart defects among offspring in the San Joaquin Valley of California.","volume":"135","author":"Carmichael","year":"2014","journal-title":"Environ Res"},{"key":"2026080506043446300_micit7","unstructured":"Center for Food Safety\n          . 2014. Heavy Costs: Weighing the Value of Neonicotinoid Insecticides in Agriculture.http:\/\/www.centerforfoodsafety.org\/files\/neonic-efficacy_digital_29226.pdf [accessed 2 January 2015]."},{"key":"2026080506043446300_micit8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11356-014-3277-x","article-title":"Risks of large-scale use of systemic insecticides to ecosystem functioning and services.","volume":"22","author":"Chagnon","year":"2015","journal-title":"Environ Sci Pollut Res Int"},{"key":"2026080506043446300_micit9","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1006\/pest.1997.2284","article-title":"Interaction of imidacloprid metabolites and analogs with the nicotinic acetylcholine receptor of mouse brain in relation to toxicity.","volume":"58","author":"Chao","year":"1997","journal-title":"Pestic Biochem Physiol"},{"key":"2026080506043446300_micit10","doi-asserted-by":"publisher","first-page":"6082","DOI":"10.1021\/jf501397m","article-title":"Quantitative analysis of neonicotinoid insecticide residues in foods: implication for dietary exposures.","volume":"62","author":"Chen","year":"2014","journal-title":"J Agric Food Chem"},{"issue":"4","key":"2026080506043446300_micit11","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1080\/15376520590968842","article-title":"Human exposure to imidacloprid from dogs treated with Advantage\u00ae.","volume":"15","author":"Craig","year":"2005","journal-title":"Toxicol Mech Methods"},{"key":"2026080506043446300_micit12","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.jes.2014.05.034","article-title":"Biochemical and microbial soil functioning after application of the insecticide imidacloprid.","volume":"27","author":"Cyco\u0144","year":"2015","journal-title":"J Environ Sci (China)"},{"issue":"8","key":"2026080506043446300_micit13","doi-asserted-by":"publisher","first-page":"5088","DOI":"10.1021\/es506141g","article-title":"Large-scale deployment of seed treatments has driven rapid increase in use of neonicotinoid insecticides and preemptive pest management in U.S. field crops.","volume":"49","author":"Douglas","year":"2015","journal-title":"Environ Sci Technol"},{"issue":"8746","key":"2026080506043446300_micit14","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/0140-6736(91)90201-Y","article-title":"Publication bias in clinical research.","volume":"337","author":"Easterbrook","year":"1991","journal-title":"Lancet"},{"issue":"4","key":"2026080506043446300_micit15","first-page":"383","article-title":"Acute health effects on planters of conifer seedlings treated with insecticides.","volume":"53","author":"Elfman","year":"2009","journal-title":"Ann Occup Hyg"},{"key":"2026080506043446300_micit16","unstructured":"FDA (U.S. Food and Drug Administration)\n          . 2014. Pesticide Monitoring Program: 2011 Pesticide Report.http:\/\/www.fda.gov\/downloads\/Food\/FoodborneIllnessContaminants\/Pesticides\/UCM382443.pdf [accessed 19 January 2015]."},{"key":"2026080506043446300_micit17","unstructured":"FDA\n          . 2015. Pesticide Monitoring Program: Fiscal Year 2012 Pesticide Report.http:\/\/www.fda.gov\/downloads\/Food\/FoodborneIllnessContaminants\/Pesticides\/UCM432758.pdf [accessed 3 August 2015]."},{"issue":"6","key":"2026080506043446300_micit18","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1177\/0960327114522500","article-title":"Neonicotinoid insecticide exposures reported to six poison centers in Texas.","volume":"33","author":"Forrester","year":"2014","journal-title":"Hum Exp Toxicol"},{"issue":"6203","key":"2026080506043446300_micit19","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1126\/Science.1255484","article-title":"Publication bias in the social sciences: unlocking the file drawer.","volume":"345","author":"Franco","year":"2014","journal-title":"Science"},{"issue":"1","key":"2026080506043446300_micit20","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s11356-014-3180-5","article-title":"A review of the direct and indirect effects of neonicotinoids and fipronil on vertebrate wildlife.","volume":"22","author":"Gibbons","year":"2015","journal-title":"Environ Sci Pollut Res Int"},{"issue":"4","key":"2026080506043446300_micit21","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1111\/1365-2664.12111","article-title":"An overview of the environmental risks posed by neonicotinoid insecticides.","volume":"50","author":"Goulson","year":"2013","journal-title":"J Appl Ecol"},{"issue":"6229","key":"2026080506043446300_micit22","doi-asserted-by":"publisher","first-page":"1255957","DOI":"10.1126\/science.1255957","article-title":"Bee declines driven by combined stress from parasites, pesticides, and lack of flowers.","volume":"347","author":"Goulson","year":"2015","journal-title":"Science"},{"issue":"7","key":"2026080506043446300_micit23","doi-asserted-by":"publisher","first-page":"e70112","DOI":"10.1371\/journal.pone.0070112","article-title":"Reproductive effects of two neonicotinoid insecticides on mouse sperm function and early embryonic development in vitro.","volume":"8","author":"Gu","year":"2013","journal-title":"PLoS One"},{"key":"2026080506043446300_micit24","unstructured":"Haire B\n          . 2014. Are seed treatments worth the investment? Southeast Farm Press. 9 January 2014.http:\/\/southeastfarmpress.com\/soybeans\/are-seed-treatments-worth-investment [accessed 3 April 2016]."},{"key":"2026080506043446300_micit25","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.envpol.2014.06.033","article-title":"Widespread occurrence of neonicotinoid insecticides in streams in a high corn and soybean producing region, USA.","volume":"193","author":"Hladik","year":"2014","journal-title":"Environ Pollut"},{"issue":"10","key":"2026080506043446300_micit26","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1080\/19440049.2013.820356","article-title":"Comparison of the dissipation behaviour of three neonicotinoid insecticides in tea.","volume":"30","author":"Hou","year":"2013","journal-title":"Food Additives & Contaminants: Part A"},{"issue":"5","key":"2026080506043446300_micit27","doi-asserted-by":"publisher","first-page":"e97081","DOI":"10.1371\/journal.pone.0097081","article-title":"Environmental fate of soil applied neonicotinoid insecticides in an irrigated potato agroecosystem.","volume":"9","author":"Huseth","year":"2014","journal-title":"PLoS One"},{"key":"2026080506043446300_micit28","doi-asserted-by":"publisher","first-page":"2897","DOI":"10.1021\/jf101303g","article-title":"Overview of the status and global strategy for neonicotinoids.","volume":"59","author":"Jeschke","year":"2011","journal-title":"J Agric Food Chem"},{"key":"2026080506043446300_micit29","first-page":"274","article-title":"Adverse effects of pesticides residues on biochemical markers in Pakistani tobacco farmers.","volume":"1","author":"Khan","year":"2008","journal-title":"Int J Clin Exp Med"},{"issue":"1\u20134","key":"2026080506043446300_micit30","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10661-009-1107-2","article-title":"Monitoring health implications of pesticide exposure in factory workers in Pakistan.","volume":"168","author":"Khan","year":"2010","journal-title":"Environ Monit Assess"},{"issue":"1","key":"2026080506043446300_micit31","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1476-069X-13-3","article-title":"Autism spectrum disorder, flea and tick medication, and adjustments for exposure misclassification: the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study.","volume":"13","author":"Keil","year":"2014","journal-title":"Environ Health"},{"issue":"2","key":"2026080506043446300_micit32","doi-asserted-by":"publisher","first-page":"e32432","DOI":"10.1371\/journal.pone.0032432","article-title":"Nicotine-like effects of the neonicotinoid insecticides acetamiprid and imidacloprid on cerebellar neurons from neonatal rats.","volume":"7","author":"Kimura-Kuroda","year":"2012","journal-title":"PLoS One"},{"key":"2026080506043446300_micit33","unstructured":"Koshlukova S\n          . 2006. Imidacloprid: Risk Characterization Document: Dietary and Drinking Water Exposure.California Environmental Protection Agency, Department of Pesticide Regulationhttp:\/\/www.cdpr.ca.gov\/docs\/risk\/rcd\/imidacloprid.pdf [accessed 18 April 2015]."},{"issue":"1","key":"2026080506043446300_micit34","doi-asserted-by":"publisher","first-page":"e29268","DOI":"10.1371\/journal.pone.0029268","article-title":"Multiple routes of pesticide exposure for honey bees living near agricultural fields.","volume":"7","author":"Krupke","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"2026080506043446300_micit35","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1002\/jnr.22644","article-title":"Activation and modulation of human \u03b14\u03b22 nicotinic acetylcholine receptors by the neonicotinoids clothianidin and imidacloprid.","volume":"89","author":"Li","year":"2011","journal-title":"J Neurosci Res"},{"issue":"3","key":"2026080506043446300_micit36","doi-asserted-by":"publisher","first-page":"e92821","DOI":"10.1371\/journal.pone.e92821","article-title":"Widespread use and frequent detection of neonicotinoid insecticides in wetlands of Canada\u2019s Prairie Pothole Region.","volume":"9","author":"Main AR, Headley JV, Peru KM, Michel NL, Cessna AJ, Morrissey CA","year":"2014","journal-title":"PLoS One"},{"issue":"11","key":"2026080506043446300_micit37","doi-asserted-by":"publisher","first-page":"e0142172","DOI":"10.1371\/journal.pone.0142172","article-title":"Relationship between urinary N-desmethyl-acetamiprid and typical symptoms including neurological findings: a prevalence case-control study.","volume":"10","author":"Marfo","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"2026080506043446300_micit38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.7178\/jeit.1","article-title":"Immune suppression by neonicotinoid insecticides at the root of global wildlife declines.","volume":"1","author":"Mason","year":"2013","journal-title":"J Environ Immunol Toxicol"},{"issue":"4","key":"2026080506043446300_micit39","doi-asserted-by":"publisher","first-page":"e5127","DOI":"10.1371\/journal.pone.0005127","article-title":"Acute human self-poisoning with Imidacloprid compound: a neonicotinoid insecticide.","volume":"4","author":"Mohamed","year":"2009","journal-title":"PLoS One"},{"key":"2026080506043446300_micit40","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.envint.2014.10.024","article-title":"Neonicotinoid contamination of global surface waters and associated risk to aquatic invertebrates: a review.","volume":"74","author":"Morrissey","year":"2015","journal-title":"Environ Int"},{"issue":"6","key":"2026080506043446300_micit41","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1093\/beheco\/arh107","article-title":"A farewell to Bonferroni: the problems of low statistical power and publication bias.","volume":"15","author":"Nakagawa","year":"2004","journal-title":"Behav Ecol"},{"key":"2026080506043446300_micit42","unstructured":"NTP (National Toxicology Program)\n          . 2015. Handbook for Conducting a Literature-Based Health Assessment Using OHAT Approach for Systematic Review and Evidence Integration.http:\/\/ntp.niehs.nih.gov\/ntp\/ohat\/pubs\/handbookjan2015_508.pdf [accessed 7 July 2015]."},{"issue":"3","key":"2026080506043446300_micit43","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/humupd\/dmm039","article-title":"Effects of environmental and occupational pesticide exposure on human sperm: a systematic review.","volume":"14","author":"Perry","year":"2008","journal-title":"Hum Reprod Update"},{"issue":"4","key":"2026080506043446300_micit44","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1080\/15563650802644533","article-title":"Neonicotinoid insecticides: an emerging cause of acute pesticide poisoning.","volume":"47","author":"Phua","year":"2009","journal-title":"Clin Toxicol (Phila)"},{"key":"2026080506043446300_micit45","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s11356-014-3471-x","article-title":"Effects of neonicotinoids and fipronil on non-target invertebrates.","volume":"22","author":"Pisa","year":"2015","journal-title":"Environ Sci Pollut Res Int"},{"issue":"7550","key":"2026080506043446300_micit46","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/nature14420","article-title":"Seed coating with a neonicotinoid insecticide negatively affects wild bees.","volume":"521","author":"Rundl\u00f6f","year":"2015","journal-title":"Nature"},{"issue":"6211","key":"2026080506043446300_micit47","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1126\/science.1259159","article-title":"The trouble with neonicotinoids.","volume":"346","author":"S\u00e1nchez-Bayo","year":"2014","journal-title":"Science"},{"issue":"1","key":"2026080506043446300_micit48","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s11356-014-3470-y","article-title":"Systemic insecticides (neonicotinoids and fipronil): trends, uses, mode of action and metabolites.","volume":"22","author":"Simon-Delso","year":"2015","journal-title":"Environ Sci Pollut Res Int"},{"issue":"3","key":"2026080506043446300_micit49","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1584\/jpestics.29.177","article-title":"Neonicotinoids and derivatives: effects in mammalian cells and mice.","volume":"29","author":"Tomizawa","year":"2004","journal-title":"J Pestic Sci"},{"key":"2026080506043446300_micit50","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1146\/annurev.ento.48.091801.112731","article-title":"Selective toxicity of neonicotinoids attributable to specificity of insect and mammalian nicotinic receptors.","volume":"48","author":"Tomizawa","year":"2003","journal-title":"Ann Rev Entomol"},{"key":"2026080506043446300_micit51","unstructured":"USDA (U.S. Department of Agriculture)\n          . 2014. Pesticide Data Program: Annual Summary, Calendar Year 2013.https:\/\/www.ams.usda.gov\/sites\/default\/files\/media\/2013%20PDP%20Anuual%20Summary.pdf [accessed 6 December 2016]."},{"key":"2026080506043446300_micit52","unstructured":"USDA\n          . 2016. Pesticide Data Program: Annual Summary, Calendar Year 2014.https:\/\/www.ams.usda.gov\/sites\/default\/files\/media\/2014%20PDP%20Annual%20Summary.pdf [accessed 3 April 2016]."},{"key":"2026080506043446300_micit53","article-title":"Cancer Assessment Document. Evaluation of the Carcinogenic Potential for Thiamethoxam. P.C.","author":"U.S. EPA (U.S. Environmental Protection Agency)","year":"2000"},{"issue":"1","key":"2026080506043446300_micit54","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s11356-014-3229-5","article-title":"Conclusions of the Worldwide Integrated Assessment on the risks of neonicotinoids and fipronil to biodiversity and ecosystem functioning.","volume":"22","author":"van der Sluijs","year":"2015","journal-title":"Environ Sci Pollut Res Int"},{"issue":"6079","key":"2026080506043446300_micit55","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1126\/science.1215025","article-title":"Neonictinoid pesticide reduces bumble bee colony growth and queen production.","volume":"336","author":"Whitehorn","year":"2012","journal-title":"Science"},{"issue":"6","key":"2026080506043446300_micit56","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1093\/aje\/kwt324","article-title":"Residential agricultural pesticide exposures and risk of neural tube defects and orofacial clefts among offspring in the San Joaquin Valley of California.","volume":"179","author":"Yang","year":"2014","journal-title":"Am J Epidemiol"}],"container-title":["Environmental Health Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/125\/2\/155\/66403871\/ehp515.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/125\/2\/155\/66403871\/ehp515.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:52:58Z","timestamp":1786629178000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-lookup\/doi\/10.1289\/EHP515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,6]]},"references-count":56,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,7,6]]},"published-print":{"date-parts":[[2017,2,1]]}},"URL":"https:\/\/doi.org\/10.1289\/ehp515","relation":{},"ISSN":["0091-6765","1552-9924"],"issn-type":[{"value":"0091-6765","type":"print"},{"value":"1552-9924","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,6]]}}}