{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:00:35Z","timestamp":1791424835730,"version":"4.3.3"},"reference-count":15,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":393,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12,1]]},"abstract":"<jats:title>Summary:<\/jats:title>\n                  <jats:p>Quantifying the impact of exposure to environmental chemical mixtures is important for identifying risk factors for diseases and developing more targeted public health interventions. The National Institute of Environmental Health Sciences (NIEHS) held a workshop in July 2015 to address the need to develop novel statistical approaches for multi-pollutant epidemiology studies. The primary objective of the workshop was to identify and compare different statistical approaches and methods for analyzing complex chemical mixtures data in both simulated and real-world data sets. At the workshop, participants compared approaches and results and speculated as to why they may have differed. Several themes emerged: a) no one statistical approach appeared to outperform the others, b) many methods included some form of variable reduction or summation of the data before statistical analysis, c) the statistical approach should be selected based upon a specific hypothesis or scientific question, and d) related mixtures data should be shared among researchers to more comprehensively and accurately address methodological questions and statistical approaches. Future efforts should continue to design and optimize statistical approaches to address questions about chemical mixtures in epidemiological studies.<\/jats:p>","DOI":"10.1289\/ehp547","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T09:37:13Z","timestamp":1480498633000},"page":"A227-A229","source":"Crossref","is-referenced-by-count":237,"title":["Statistical Approaches for Assessing Health Effects of Environmental Chemical Mixtures in Epidemiology: Lessons from an Innovative Workshop"],"prefix":"10.1021","volume":"124","author":[{"given":"Kyla W.","family":"Taylor","sequence":"first","affiliation":[{"name":"National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie R.","family":"Joubert","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe M.","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Brown University, Providence, Rhode Island, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Dilworth","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Gennings","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russ","family":"Hauser","sequence":"additional","affiliation":[{"name":"Departments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry J.","family":"Heindel","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia V.","family":"Rider","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"Webster","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle J.","family":"Carlin","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2016,12,1]]},"reference":[{"issue":"3","key":"2026080314104513600_micit1","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1289\/ehp.1205740","article-title":"Evaluation of biomonitoring data from the CDC National Exposure Report in a risk assessment context: perspectives across chemicals.","volume":"121","author":"Aylward","year":"2013","journal-title":"Environ Health Perspect"},{"key":"2026080314104513600_micit2","article-title":"Bayley Scales of Infant Development. 1st Edition.","author":"Bayley N","year":"1969"},{"issue":"1","key":"2026080314104513600_micit3","doi-asserted-by":"publisher","first-page":"A6","DOI":"10.1289\/ehp.1510569","article-title":"What can epidemiological studies tell us about the impact of chemical mixtures on human health?","volume":"124","author":"Braun","year":"2016","journal-title":"Environ Health Perspect"},{"key":"2026080314104513600_micit4","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw006","article-title":"Cohort profile: Health 0utcomes and Measures of the Environment (HOME) study.","author":"Braun","year":"2016","journal-title":"Int J Epidemiol"},{"issue":"1","key":"2026080314104513600_micit5","doi-asserted-by":"publisher","first-page":"A6","DOI":"10.1289\/ehp.1206182","article-title":"Unraveling the health effects of environmental mixtures: an NIEHS priority.","volume":"121","author":"Carlin","year":"2013","journal-title":"Environ Health Perspect"},{"key":"2026080314104513600_micit6","unstructured":"CDC (Centers for Disease Control and Prevention)\n          . 2012. 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