{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:35:56Z","timestamp":1787495756137,"version":"build-2736575974"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ Health Perspect"],"published-print":{"date-parts":[[2017,5,24]]},"DOI":"10.1289\/ehp788","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T01:13:08Z","timestamp":1496365988000},"source":"Crossref","is-referenced-by-count":38,"title":["Characterization of Variability in Toxicokinetics and Toxicodynamics of Tetrachloroethylene Using the Collaborative Cross Mouse Population"],"prefix":"10.1021","volume":"125","author":[{"given":"Joseph A.","family":"Cichocki","sequence":"first","affiliation":[{"name":"Department of Veterinary Integrative Biosciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Furuya","sequence":"additional","affiliation":[{"name":"Department of Veterinary Integrative Biosciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Venkatratnam","sequence":"additional","affiliation":[{"name":"Department of Veterinary Integrative Biosciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony H.","family":"Knap","sequence":"additional","affiliation":[{"name":"Geochemical and Environmental Research Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Wade","sequence":"additional","affiliation":[{"name":"Geochemical and Environmental Research Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Sweet","sequence":"additional","affiliation":[{"name":"Geochemical and Environmental Research Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihsueh A.","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Integrative Biosciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Threadgill","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Medicine, Texas A&amp;M University, College Station, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Rusyn","sequence":"additional","affiliation":[{"name":"Department of Veterinary Integrative Biosciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","reference":[{"key":"e_1_3_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002040050284"},{"key":"e_1_3_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq362"},{"key":"e_1_3_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(85)90310-2"},{"key":"e_1_3_1_5_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1307623"},{"key":"e_1_3_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2011.03.020"},{"key":"e_1_3_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfl129"},{"key":"e_1_3_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1104-1133"},{"key":"e_1_3_1_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.116.232629"},{"key":"e_1_3_1_10_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.111.132639"},{"key":"e_1_3_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2006.06.008"},{"key":"e_1_3_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3222"},{"key":"e_1_3_1_13_1","volume-title":"Determination of haloacetic acids and dalapon in drinking water by liquid-liquid microextraction, derivatization, and gas chromatography with electron capture detection","author":"Domino MM","year":"2003"},{"key":"e_1_3_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2003.10.006"},{"key":"e_1_3_1_15_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1408202"},{"key":"e_1_3_1_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/2291566"},{"key":"e_1_3_1_17_1","unstructured":"Goehl E O'Neil J. 2005. Dry Cleaning Docket: Background Information Document. http:\/\/www3.epa.gov\/airtoxics\/dryperc\/11-14-05background.pdf [Online 1 June 2016]."},{"key":"e_1_3_1_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005504"},{"key":"e_1_3_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70485-0"},{"key":"e_1_3_1_20_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1307359"},{"key":"e_1_3_1_21_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.090241.108"},{"key":"e_1_3_1_22_1","article-title":"Trichloroethylene, tetrachloroethylene and some other chlorinated agents","volume":"106","author":"IARC (International Agency for Research on Cancer)","year":"2013","journal-title":"IARC Monogr Eval Carcinog Risk Hum"},{"key":"e_1_3_1_23_1","volume-title":"Chemical-Specific Adjustment Factors For Interspecies Differences And Human Variability: Guidance Document For Use Of Data In Dose\/Concentration\u2013Response Assessment","author":"IPCS (International Programme on Chemical Safety)","year":"2005"},{"key":"e_1_3_1_24_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.106.010538"},{"key":"e_1_3_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2014.04.003"},{"key":"e_1_3_1_26_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0031-6997(24)01491-1","article-title":"Hepatic and renal toxicities associated with perchloroethylene","volume":"53","author":"Lash LH","year":"2001","journal-title":"Pharmacol Rev"},{"key":"e_1_3_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2007.03.001"},{"key":"e_1_3_1_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1999.8809"},{"key":"e_1_3_1_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00378619"},{"key":"e_1_3_1_30_1","volume-title":"Contaminated Water Supplies at Camp Lejeune: Assessing Potential Health Effects","author":"National Research Council","year":"2009"},{"key":"e_1_3_1_31_1","volume-title":"Science and Decisions: Advancing Risk Assessment","author":"National Research Council","year":"2009"},{"key":"e_1_3_1_32_1","volume-title":"Review of the Environmental Protection Agency\u2019s Draft IRIS Assessment of Tetrachloroethylene","author":"National Research Council","year":"2010"},{"key":"e_1_3_1_33_1","first-page":"1","article-title":"NTP Toxicology and Carcinogenesis Studies of Tetrachloroethylene (Perchloroethylene) (CAS no. 127-18-4) in F344\/N rats and B6C3F1 Mice (Inhalation Studies)","volume":"311","author":"National Toxicology Program","year":"1986","journal-title":"Natl Toxicol Program Tech Rep Ser"},{"key":"e_1_3_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(79)90371-5"},{"key":"e_1_3_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2006.12.018"},{"key":"e_1_3_1_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2013.59"},{"key":"e_1_3_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2008.04.020"},{"key":"e_1_3_1_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1259595"},{"key":"e_1_3_1_39_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.10.100"},{"key":"e_1_3_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(80)90082-4"},{"key":"e_1_3_1_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/etc.665"},{"key":"e_1_3_1_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.52.1.24"},{"key":"e_1_3_1_43_1","volume-title":"Toxicological Review of Trichloroacetic Acid","author":"U.S. EPA (U.S. Environmental Protection Agency)","year":"2011"},{"key":"e_1_3_1_44_1","volume-title":"Toxicological Review of Tetrachloroethylene (CAS no. 127-18-4): In Support of Summary Information on the Integrated Risk Information System (IRIS). EPA\/635\/R-08\/011A","author":"U.S. EPA","year":"2011"},{"key":"e_1_3_1_45_1","volume-title":"Toxicological Review of Trichloroethylene (CAS no. 79-01-6): In Support of Summary Information on the Integrated Risk Information System (IRIS). EPA\/635\/R-09\/011F","author":"U.S. EPA","year":"2011"},{"key":"e_1_3_1_46_1","volume-title":"Next Generation Risk Assessment: Incorporation of Recent Advances in Molecular, Computational, and Systems Biology. EPA\/600\/R-14\/004","author":"U.S. EPA","year":"2014"},{"key":"e_1_3_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(00)00281-2"},{"key":"e_1_3_1_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287394.2015.958417"},{"key":"e_1_3_1_49_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1205687"}],"container-title":["Environmental Health Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ehp.niehs.nih.gov\/doi\/pdf\/10.1289\/EHP788","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:49:30Z","timestamp":1786628970000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-lookup\/doi\/10.1289\/EHP788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,24]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5,24]]}},"alternative-id":["10.1289\/EHP788"],"URL":"https:\/\/doi.org\/10.1289\/ehp788","relation":{},"ISSN":["0091-6765","1552-9924"],"issn-type":[{"value":"0091-6765","type":"print"},{"value":"1552-9924","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,24]]},"article-number":"057006"}}