{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:02:55Z","timestamp":1760608975943,"version":"3.44.0"},"reference-count":4,"publisher":"SMC Media","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"Autoimmune hepatitis (AIH) is a disease of unknown aetiology with drug-induced AIH being the most complex and not fully understood type. We present the case of a 57-year-old female patient with acute icteric hepatitis after interferon-beta-1b (IFN?-1b) administration for multiple sclerosis (MS). Based on liver autoimmune serology, histology and appropriate exclusion of other liver diseases, a diagnosis of AIH-related cirrhosis was established. Following discontinuation of IFN?-1b, a complete resolution of biochemical activity indices was observed and the patient remained untreated on her own decision. However, 3 years later, after a course of intravenous methylprednisolone for MS, a new acute transaminase flare was recorded which subsided again spontaneously after 3 weeks. Liver biopsy and elastography showed significant fibrosis regression (F2 fibrosis). To our knowledge, this is the first report showing spontaneous cirrhosis regression in an IFN?-1b-induced AIH-like syndrome following drug withdrawal, suggesting that cirrhosis might be reversible if the offending fibrogenic stimulus is withdrawn.<\/jats:p>","DOI":"10.12890\/2016_000396","type":"journal-article","created":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T06:32:16Z","timestamp":1490855536000},"source":"Crossref","is-referenced-by-count":2,"title":["Spontaneous Cirrhosis Regression in an IFN-beta-induced AIH-like Syndrome Following Drug Withdrawal: Art of Facts or Artifacts?"],"prefix":"10.12890","volume":"3","author":[{"given":"Maria","family":"Kalafateli","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital of Patras"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Triantos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital of Patras"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios","family":"Tsamandas","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital of Patras"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George N","family":"Dalekos","sequence":"additional","affiliation":[{"name":"Department of Medicine and Research Laboratory of Internal Medicine, School of Medicine, University of Thessaly, Larissa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2016,6,7]]},"reference":[{"key":"10.12890\/2016_000396_ref1","doi-asserted-by":"crossref","unstructured":"
  • Zachou K, Muratori P, Koukoulis GK, Granito A, Gatselis N, Fabbri A, et al. Review article: autoimmune hepatitis - current management and challenges. Aliment Pharmacol Ther<\/em> 2013;38<\/strong>:887\u2013913.<\/li>","DOI":"10.1111\/apt.12470"},{"key":"10.12890\/2016_000396_ref2","doi-asserted-by":"crossref","unstructured":"
  • EASL Clinical Practice Guidelines: Autoimmune hepatitis. J Hepatol <\/em>2015;63<\/strong>:971\u20131004.<\/li>","DOI":"10.1016\/j.jhep.2015.06.030"},{"key":"10.12890\/2016_000396_ref3","doi-asserted-by":"crossref","unstructured":"
  • Hytiroglou P, Snover DC, Alves V, Balabaud C, Bhathal PS, Bioulac-Sage P, et al. Beyond \"cirrhosis\": a proposal from the International Liver Pathology Study Group. Am J Clin Pathol<\/em> 2012;137<\/strong>:5\u20139.<\/li>","DOI":"10.1309\/AJCP2T2OHTAPBTMP"},{"key":"10.12890\/2016_000396_ref4","doi-asserted-by":"crossref","unstructured":"
  • Zachou K, Gatselis N, Papadamou G, Rigopoulou EI, Dalekos GN. Mycophenolate for the treatment of autoimmune hepatitis: prospective assessment of its efficacy and safety for induction and maintenance of remission in a large cohort of treatment-naive patients. J Hepatol<\/em> 2011;55<\/strong>:636\u2013646.<\/li>","DOI":"10.1016\/j.jhep.2010.12.032"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/396\/552","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/396\/553","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/396\/553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:48:50Z","timestamp":1756367330000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,7]]},"references-count":4,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.12890\/2016_000396","relation":{"has-manifestation":[{"id-type":"other","id":"1-15-396-g552","asserted-by":"subject"},{"id-type":"other","id":"1-15-396-g553","asserted-by":"subject"},{"id-type":"other","id":"1-15-396-g1173","asserted-by":"subject"},{"id-type":"other","id":"1-15-396-g1174","asserted-by":"subject"},{"id-type":"other","id":"1-15-396-g1175","asserted-by":"subject"},{"id-type":"other","id":"1-15-396-g1176","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-15","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2016,6,7]]},"article-number":"3"}}