{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:34:43Z","timestamp":1791326083434,"version":"4.3.1"},"reference-count":0,"publisher":"SMC Media","issue":"Vol 6 Iss 12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Iatrogenic antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is not exceptional. Many cases of small vessel vasculitis induced by anti-thyroid drugs (ATD), mainly propylthiouracil (PTU), have been reported. We present a case of AAV related to another ATD: benzylthiouracil (BTU) and review the literature. An 84-year-old man with a 4-year history of multinodular goitre with hyperthyroidism was treated with BTU. He presented an acute syndrome with weakness, fever, epigastric pain and abdominal distension. Lactate and lipase tests were normal. An abdominal scan showed a thrombosis of the splenic artery with splenic infarction. We excluded a hypothesis of associated embolic aetiology: atrial fibrillation, atrial myxoma, intraventricular thrombus or artery aneurysm. Exploration of a possible prothrombotic state (complete blood count, haemostasis tests, activated protein C resistance, factor V Leiden, protein C, S, antithrombin III) gave normal results. Tests for antinuclear antibodies (ANA) and antiphospholipid antibodies (APL) were negative. However, testing for p-ANCA, with antimyeloperoxidase (MPO) specificity, was positive: 120.6 CU (N&lt;20.0). We did not find other systemic manifestations, except a non-specific kidney failure. BTU was discontinued without steroids or immune-modulating drugs. Subsequently, symptoms disappeared progressively and titres of ANCA fell until normalization, 4 months later. Many patients treated with BTU present a high prevalence of ANCA, mainly, but not exclusively, directed against MPO. Vasculitis, however, remains an uncommon complication. The mechanism of this anomaly remains to be elucidated. Some studies suggest the possibility of an autoimmune reaction initiated by drug bioactivation mediated by neutrophil-derived MPO. The present observation is particular because the involved drug was BTU and clinical expression was unusual.<\/jats:p>","DOI":"10.12890\/2019_001283","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T13:52:37Z","timestamp":1621950757000},"source":"Crossref","is-referenced-by-count":1,"title":["Benzylthiouracil-induced ANCA-associated Vasculitis: A Case Report and Literature Review"],"prefix":"10.12890","author":[{"family":"Fatima Bensiradj","sequence":"first","affiliation":[{"name":"F\u00e9d\u00e9ration de M\u00e9decine G\u00e9riatrie Th\u00e9rapeutique, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Mathilde Hignard","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacie, CHU de Rouen, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Rand Nakkash","sequence":"additional","affiliation":[{"name":"F\u00e9d\u00e9ration de M\u00e9decine G\u00e9riatrie Th\u00e9rapeutique, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Alice Proux","sequence":"additional","affiliation":[{"name":"F\u00e9d\u00e9ration de M\u00e9decine G\u00e9riatrie Th\u00e9rapeutique, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Nathalie Massy","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Pharmacovigilance, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Nadir Kadri","sequence":"additional","affiliation":[{"name":"F\u00e9d\u00e9ration de M\u00e9decine G\u00e9riatrie Th\u00e9rapeutique, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Jean Doucet","sequence":"additional","affiliation":[{"name":"F\u00e9d\u00e9ration de M\u00e9decine G\u00e9riatrie Th\u00e9rapeutique, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Isabelle Landrin","sequence":"additional","affiliation":[{"name":"F\u00e9d\u00e9ration de M\u00e9decine G\u00e9riatrie Th\u00e9rapeutique, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10397","published-online":{"date-parts":[[2019,12,10]]},"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"deposited":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T13:55:17Z","timestamp":1621950917000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/1283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,10]]},"references-count":0,"journal-issue":{"issue":"Vol 6 Iss 12","published-online":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.12890\/2019_001283","relation":{"has-manifestation":[{"id-type":"other","id":"1-53-1283-g1867","asserted-by":"subject"},{"id-type":"other","id":"1-53-1283-g1868","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-53","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,10]]},"article-number":"4"}}