{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T14:10:17Z","timestamp":1756476617208,"version":"3.44.0"},"reference-count":25,"publisher":"SMC Media","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Myeloid sarcoma (MS) is a very rare malignant tumour composed of myeloblasts. It most commonly involves soft tissue, bone, periosteum and lymph nodes, but unusual presentation sites have also been reported. Typically, MS evolves concurrently with active leukaemia or following remission, when it is known as secondary MS. But rarely MS can occur de novo without evidence of concomitant haematological disease. Herein, we report an unusual case of central nervous system-MS in a patient without evidence of concomitant haematological disease. In this case, progressive thoracic and lumbar pain with paraplegia ultimately led to the diagnosis of acute myeloid leukaemia. We also conducted a PubMed search for case reports, case series and reviews of past literature regarding central nervous system-MS and report our findings.<\/jats:p>","DOI":"10.12890\/2020_001802","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:52:37Z","timestamp":1621936357000},"source":"Crossref","is-referenced-by-count":1,"title":["Liquid Presenting as Solid: A Rare Presentation of Acute Myeloid Leukaemia as a Solid Epidural Mass"],"prefix":"10.12890","volume":"7","author":[{"given":"Varsha","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jersey Shore University Medical Center, Neptune, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firas","family":"Ajam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jersey Shore University Medical Center, Neptune, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Conte","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jersey Shore University Medical Center, Neptune, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alsadiq","family":"Al Hillan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jersey Shore University Medical Center, Neptune, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadhim","family":"Al-Banaa","sequence":"additional","affiliation":[{"name":"Department of Medicine, Beaumont Hospital, Dearborn, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinit","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Medical Oncology, Yale School of Medicine, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Levitt","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Jersey Shore University Medical Center, Neptune, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2020,9,8]]},"reference":[{"key":"10.12890\/2020_001802_ref1","doi-asserted-by":"crossref","unstructured":"<li>Dores GM, Devesa SS, Curtis RE, MS Linet, Morton LM. 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Intracranial CNS manifestations of myeloid sarcoma in patients with acute myeloid leukemia: review of the literature and three case reports from the author\u2019s institution. <em>J Clin Med<\/em> 2015;<strong>4<\/strong>(5):1102\u20131112.<\/li>","DOI":"10.3390\/jcm4051102"},{"key":"10.12890\/2020_001802_ref14","doi-asserted-by":"crossref","unstructured":"<li>Pi\u00f1\u00e1n MA, Ardanaz MT, Guinea JM, Garc\u00eda-Ruiz JC. Myeloid sarcoma preceding an acute promyelocytic leukaemia with neuromeningeal infiltration. <em>Ann Hematol<\/em> 2014;<strong>93<\/strong>(2):339\u2013340.<\/li>","DOI":"10.1007\/s00277-013-1795-0"},{"key":"10.12890\/2020_001802_ref15","doi-asserted-by":"crossref","unstructured":"<li>Widhalm G, Dietrich W, M\u00fcllauer L, Streubel B, Rabitsch W, Kotter MR, et al. Myeloid sarcoma with multiple lesions of the central nervous system in a patient without leukemia. Case report. <em>J Neurosurg<\/em> 2006;<strong>105<\/strong>(6):916\u2013919.<\/li>","DOI":"10.3171\/jns.2006.105.6.916"},{"key":"10.12890\/2020_001802_ref16","doi-asserted-by":"crossref","unstructured":"<li>Yang B, Yang C, Fang J, Yang J, Xu Y. Clinicoradiological characteristics, management and prognosis of primary myeloid sarcoma of the central nervous system: a report of four cases. <em>Oncol Lett<\/em> 2017;<strong>14<\/strong>(3):3825\u20133831.<\/li>","DOI":"10.3892\/ol.2017.6620"},{"key":"10.12890\/2020_001802_ref17","doi-asserted-by":"crossref","unstructured":"<li>Cuglievan B, Menegaz BA, Garces S, Rytting ME. Acute myeloid leukaemia masquerading as a primary CNS tumour. <em>BMJ Case Rep<\/em> 2017;2017:bcr-2017-220891. <\/li>","DOI":"10.1136\/bcr-2017-220891"},{"key":"10.12890\/2020_001802_ref18","doi-asserted-by":"crossref","unstructured":"<li>Imrie KR, Kovacs MJ, Selby D, Lipton J, Patterson BJ, Pantalony D, et al. Isolated chloroma: the effect of early antileukemic therapy. <em>Ann Intern Med<\/em>1995;<strong>123<\/strong>(5):351\u2013353.<\/li>","DOI":"10.7326\/0003-4819-123-5-199509010-00005"},{"key":"10.12890\/2020_001802_ref19","doi-asserted-by":"crossref","unstructured":"<li>Olar A, Lapadat R, Davidson CJ. Central nervous system involvement by myeloid sarcoma: a report of 12 cases and review of the literature. <em>Clin Neuropathol<\/em> 2016;<strong>35<\/strong>(5):314\u2013325. <\/li>","DOI":"10.5414\/NP300949"},{"key":"10.12890\/2020_001802_ref20","doi-asserted-by":"crossref","unstructured":"<li>Gill AS, Gill R, Kaloostian P. Intracranial myeloid sarcoma metastasis mimicking acute subdural hematoma. <em>Case Rep Surg<\/em> 2017;<strong>2017<\/strong>:3056285. <\/li>","DOI":"10.1155\/2017\/3056285"},{"key":"10.12890\/2020_001802_ref21","doi-asserted-by":"crossref","unstructured":"<li>Novello M, Coli A, Della Pepa GM. 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Isolated central nervous system chloroma as a presenting sign of relapsed pediatric acute lymphoblastic leukemia. <em>J Pediatr Hematol Oncol<\/em> 2018;<strong>40<\/strong>(7):e442\u2013e445. <\/li>","DOI":"10.1097\/MPH.0000000000001085"},{"key":"10.12890\/2020_001802_ref25","doi-asserted-by":"crossref","unstructured":"<li>Algharras AA, Mamourian A, Coyne T. Leukostasis in an adult with AML presenting as multiple high attenuation brain masses on CT. <em>J Clin Diagn Res<\/em> 2013;<strong>7<\/strong>(12):3020\u20133022.<\/li>","DOI":"10.7860\/JCDR\/2013\/6638.3893"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1802\/2329","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1802\/2330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1802\/2330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T13:28:25Z","timestamp":1756474105000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/1802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,8]]},"references-count":25,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.12890\/2020_001802","relation":{"has-manifestation":[{"id-type":"other","id":"1-64-1802-g2329","asserted-by":"subject"},{"id-type":"other","id":"1-64-1802-g2330","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-64","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2020,9,8]]},"article-number":"41"}}