{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:40:01Z","timestamp":1760240401702,"version":"3.44.0"},"reference-count":5,"publisher":"SMC Media","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Rendu-Osler-Weber syndrome is a rare inherited syndrome with autosomal dominant transmission characterized by systemic arteriovenous malformations (AVMs) with multi-organ involvement. Its incidence is 1\u20132\/100,000 and it is predominant in females (the male\/female ratio varies from 1:2 to 1:4.5).Clinical manifestations and complications are related to recurrent bleeding and, in some cases, the development of end-organ failure. Management is mostly supportive care and it is essential to promote control of the disease as much as possible and screen eventual complications. We describe the case of a 67-year-old male patient with Rendu-Osler-Weber syndrome admitted to the emergency department with decompensated heart failure due to acute anaemia because of severe epistaxis. During hospitalization, the patient progressed to acute-on-chronic liver failure with hepatic encephalopathy and an abdominal computed tomography scan showed multiple hepatic AVMs considered to be the cause of the chronic liver disease.<\/jats:p>","DOI":"10.12890\/2020_001831","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:52:37Z","timestamp":1621936357000},"source":"Crossref","is-referenced-by-count":1,"title":["Osler-Weber-Rendu Syndrome with Severe Hepatic Manifestations: A Rare Clinical Case"],"prefix":"10.12890","volume":"7","author":[{"given":"Maria In\u00eas","family":"Silva","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Prof. Dr. Fernando Fonseca EPE, Amadora, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Matos","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Prof. Dr. Fernando Fonseca EPE, Amadora, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Correia","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Prof. Dr. Fernando Fonseca EPE, Amadora, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Carola","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Prof. Dr. Fernando Fonseca EPE, Amadora, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jo\u00e3o","family":"Gomes","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Prof. Dr. Fernando Fonseca EPE, Amadora, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Branco","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Prof. Dr. Fernando Fonseca EPE, Amadora, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2020,8,3]]},"reference":[{"key":"10.12890\/2020_001831_ref1","doi-asserted-by":"crossref","unstructured":"<li>Tortora A, Riccioni ME, Gaetani E, Ojetti V, Holleran G, Gasbarrini A. Rendu-Osler-Weber disease: a gastroenterologist\u2019s perspective. <em>Orphanet J Rare Dis<\/em> 2019;<strong>14<\/strong>:130.","DOI":"10.1186\/s13023-019-1107-4"},{"key":"10.12890\/2020_001831_ref2","doi-asserted-by":"crossref","unstructured":"<li>Barbosa AB, Hans-Filho G, Vicari CFS, Medeiros MZ, Couto DV, Takita LC. Rendu-Osler-Weber syndrome: dermatological approach. <em>An Bras Dermatol<\/em> 2015;<strong>90<\/strong>(3 Suppl 1):S226\u2013S228.","DOI":"10.1590\/abd1806-4841.20152563"},{"key":"10.12890\/2020_001831_ref3","doi-asserted-by":"crossref","unstructured":"<li>Lesca G, Olivieri C, Burnichon N, Pagella F, Carette MF, Gilbert-Dussardier B, et al. Genotype-phenotype correlations in hereditary hemorrhagic telangiectasia: data from the French-Italian HHT network. <em>Genet Med<\/em> 2007;<strong>9<\/strong>:14\u201322.","DOI":"10.1097\/GIM.0b013e31802d8373"},{"key":"10.12890\/2020_001831_ref4","unstructured":"<li>Shovlin C. Clinical manifestations and diagnosis of hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome). UpToDate 2019. Available from: https:\/\/www.uptodate.com\/contents\/clinical-manifestations-and-diagnosis-of-hereditary-hemorrhagic-telangiectasia-osler-weber-rendu-syndrome (accessed 11 May 2020)."},{"key":"10.12890\/2020_001831_ref5","unstructured":"<li>McDonald J, Pyeritz RE. Hereditary hemorrhagic telangiectasia. 2000 Jun 26 [Updated 2017 Feb 2]. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Amemiya A, Bean LJ, et al., editors. GeneReviews\u00ae [Internet], Seattle (WA): University of Washington, Seattle; 1993\u20132020. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1351\/<\/li>"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1831\/2275","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1831\/2276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1831\/2276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T13:29:13Z","timestamp":1756474153000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/1831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,3]]},"references-count":5,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.12890\/2020_001831","relation":{"has-manifestation":[{"id-type":"other","id":"1-64-1831-g2275","asserted-by":"subject"},{"id-type":"other","id":"1-64-1831-g2276","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-64","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2020,8,3]]},"article-number":"60"}}