{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T14:10:02Z","timestamp":1756476602038,"version":"3.44.0"},"reference-count":6,"publisher":"SMC Media","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>A 44-year-old woman with no significant medical history presented with a 3-week history of high-grade fevers, fatigue and shortness of breath. Laboratory investigation was significant for lymphopenia and thrombocytopenia which progressively worsened during her hospital stay, along with new-onset anaemia, and elevated ferritin, transaminase and triglycerides. A computerized tomography (CT) scan of the abdomen revealed retroperitoneal lymphadenopathy. A bone marrow biopsy confirmed the diagnosis of haemophagocytic lymphohistiocytosis (HLH). Extensive infectious work-up revealed high IgG titres for Bartonella henselae and Coxiella burnetii. Interestingly, the left supraclavicular node was negative for both microbes by polymerase chain reaction (PCR), but the biopsy revealed anaplastic large T-cell lymphoma.<\/jats:p>","DOI":"10.12890\/2020_001850","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:52:37Z","timestamp":1621936357000},"source":"Crossref","is-referenced-by-count":1,"title":["Anaplastic Large Cell Lymphoma Presenting as Haemophagocytic Lymphohistiocytosis with Underlying Coxiella burnetii and Bartonella henselae Seropositivity"],"prefix":"10.12890","volume":"7","author":[{"given":"Mohammad","family":"Ammad Ud Din","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Rochester General Hospital, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Ather","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Rochester General Hospital, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bassil","family":"Said","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Rochester General Hospital, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aneeqa","family":"Zafar","sequence":"additional","affiliation":[{"name":"Department of Hospitalist Medicine, El Camino Hospital, Mountain View, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"key":"10.12890\/2020_001850_ref1","doi-asserted-by":"crossref","unstructured":"<li>Ibrahim U, Saqib A, Rehan M, Atallah JP. ALK-negative anaplastic large cell lymphoma presenting as disseminated intravascular coagulation and hemophagocytic lymphohistiocytosis: a potentially fatal presentation. <em>Case Rep Hematol<\/em>2018;<strong>2018<\/strong>:3465351.<\/li>","DOI":"10.1155\/2018\/3465351"},{"key":"10.12890\/2020_001850_ref2","doi-asserted-by":"crossref","unstructured":"<li>Harris P, Dixit R, Norton R. <em>Coxiella burnetii<\/em> causing haemophagocytic syndrome: a rare complication of an unusual pathogen. <em>Infection<\/em> 2011;<strong>39<\/strong>(6):579\u2013582.<\/li>","DOI":"10.1007\/s15010-011-0142-4"},{"key":"10.12890\/2020_001850_ref3","doi-asserted-by":"crossref","unstructured":"<li>Melenotte C, Million M, Audoly G, Gorse A, Dutronc H, Roland G, et al. B-cell non-Hodgkin lymphoma linked to Coxiella burnetii. <em>Blood<\/em> 2016;<strong>127<\/strong>(1):113\u2013121.<\/li>","DOI":"10.1182\/blood-2015-04-639617"},{"key":"10.12890\/2020_001850_ref4","doi-asserted-by":"crossref","unstructured":"<li>Chen TC, Chang K, Lu PL, Liu YC, Chen YH, Hsieh HC, et al. Acute Q fever with hemophagocytic syndrome: case report and literature review. <em>Scand J Infect Dis<\/em> 2006;<strong>38<\/strong>(11\u201312):1119\u20131122.<\/li>","DOI":"10.1080\/00365540600684405"},{"key":"10.12890\/2020_001850_ref5","doi-asserted-by":"crossref","unstructured":"<li>Khateeb J, Stern A, Yaseen H, Levi Y, Khamaisi M. Chronic Q fever infection mimicking hematological malignancy. <em>Infect Dis Clin Pract<\/em> 2018;<strong>26<\/strong>(6):e77\u2013e79.<\/li>","DOI":"10.1097\/IPC.0000000000000639"},{"key":"10.12890\/2020_001850_ref6","doi-asserted-by":"crossref","unstructured":"<li>Poudel A, Lew J, Slayton W, Dharnidharka VR. <em>Bartonella henselae<\/em> infection inducing hemophagocytic lymphohistiocytosis in a kidney transplant recipient. <em>Pediatr Transplant<\/em> 2014;<strong>18<\/strong>(3):E83\u2013E87.<\/li>","DOI":"10.1111\/petr.12235"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1850\/2283","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1850\/2284","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1850\/2284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T13:29:05Z","timestamp":1756474145000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/1850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,7]]},"references-count":6,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.12890\/2020_001850","relation":{"has-manifestation":[{"id-type":"other","id":"1-64-1850-g2283","asserted-by":"subject"},{"id-type":"other","id":"1-64-1850-g2284","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-64","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2020,8,7]]},"article-number":"56"}}