{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T14:10:02Z","timestamp":1756476602687,"version":"3.44.0"},"reference-count":4,"publisher":"SMC Media","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>We describe the case of a 66-year-old woman with littoral cell angioma (LCA) confirmed by histopathology and immunohistochemistry, to our knowledge the first case in Belgium. LCA is an extremely rare primary vascular tumour of the splenic red pulp, probably originating from littoral cells. If a splenic mass and nodules are incidentally identified on imaging and the patient has no associated signs or symptoms, LCA should be suspected. Histopathology and adjacent techniques are mandatory for definitive diagnosis. Splenectomy followed by adequate follow-up is necessary to exclude underlying pathology.<\/jats:p>","DOI":"10.12890\/2020_001863","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:52:37Z","timestamp":1621936357000},"source":"Crossref","is-referenced-by-count":0,"title":["Multi-Focal Splenic Tumour in a Belgian Patient and a Brief Review of the Literature on Littoral Cell Angioma"],"prefix":"10.12890","volume":"7","author":[{"given":"Maaike","family":"Ramael","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Schoeters","sequence":"additional","affiliation":[{"name":"Department of Gastro-enterology, General Hospital AZ Herentals, Herentals, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"De Pooter","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery, General Hospital AZ Herentals, Herentals, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik","family":"Van Sonhoven","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Imaging, General Hospital AZ Herentals, Herentals, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilde","family":"Van Steelandt","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Imaging, General Hospital AZ Herentals, Herentals, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Swaegers","sequence":"additional","affiliation":[{"name":"Department of Radiology, H\u00f4pital du Valais, Sion, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim","family":"Develter","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Pathology, Heilig Hartziekenhuis Lier, Lier, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Ramael","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Pathology, Heilig Hartziekenhuis Lier, Lier, Belgium; Laboratory of Histology and Cell Biology, University of Antwerp, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2020,8,29]]},"reference":[{"key":"10.12890\/2020_001863_ref1","doi-asserted-by":"crossref","unstructured":"<li>Falck S, Stutte HJ, Frizzera G. Littoral cell angioma. A novel splenic vascular lesion demonstrating histiocytic differentiation. <em>Am J Surg Pathol<\/em> 1991;<strong>15<\/strong>:1023\u20131033.<li>","DOI":"10.1097\/00000478-199111000-00001"},{"key":"10.12890\/2020_001863_ref2","doi-asserted-by":"crossref","unstructured":"<li>Peckova K, Michal M, Hadravsky L, Suster S, Damjanov I, Miesbauerova M, et al. Littoral cell angioma of the spleen: a study of 25 cases with confirmation of frequent association with visceral malignancies. <em>Histopathology<\/em> 2016;<strong>69<\/strong>(5):762\u2013774. <li>","DOI":"10.1111\/his.13026"},{"key":"10.12890\/2020_001863_ref3","unstructured":"<li>Liu Z, Zhu J, Peng L, Tu Y, Li Y, Xiao W. Littoral cell angioma of the spleen: three cases report and literature review. <em>Int J Clin Exp Med<\/em> 2018;<strong>11<\/strong>(2):1077\u20131081.<li>"},{"key":"10.12890\/2020_001863_ref4","doi-asserted-by":"crossref","unstructured":"<li>Shweta B, Jiaoti H, Vikram D. Littoral cell angioma of the spleen. <em>Am J Roentgenol<\/em>2007;<strong>188<\/strong>:1365\u20131366.<li>","DOI":"10.2214\/AJR.06.1157"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1863\/2309","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1863\/2310","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1863\/2310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T13:28:39Z","timestamp":1756474119000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/1863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,29]]},"references-count":4,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.12890\/2020_001863","relation":{"has-manifestation":[{"id-type":"other","id":"1-64-1863-g2309","asserted-by":"subject"},{"id-type":"other","id":"1-64-1863-g2310","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-64","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2020,8,29]]},"article-number":"45"}}