{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T14:10:02Z","timestamp":1756476602266,"version":"3.44.0"},"reference-count":9,"publisher":"SMC Media","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Significant leucocytosis in the setting of an underlying malignancy may be attributed to several causes and is not uncommon; however, extreme leucocytosis (&gt;50\u00d7109 cells\/l) and hypereosinophilia is less common and may represent a paraneoplastic syndrome. The underlying mechanism is thought to be bone marrow stimulation by tumour-produced cytokines, most notably interleukin-5 (IL-5) and granulocyte-macrophage colony-stimulating factor (GM-CSF). This paraneoplastic syndrome is likely reflective of extensive disease and dissemination, and options for treatment are limited but include tumour resection, corticosteroids and hydroxyurea. In this report, we discuss an unusual case of known stage III lung adenocarcinoma presenting with an ischaemic stroke and extreme leucocytosis and hypereosinophilia.\u00a0<\/jats:p>","DOI":"10.12890\/2020_001872","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:52:37Z","timestamp":1621936357000},"source":"Crossref","is-referenced-by-count":2,"title":["Leucocytosis and Stroke in a Lung Cancer Patient"],"prefix":"10.12890","volume":"7","author":[{"given":"Neha","family":"Akkad","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Washington University, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, University of California Los Angeles, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, University of California Los Angeles, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"key":"10.12890\/2020_001872_ref1","doi-asserted-by":"crossref","unstructured":"<li>Kanaji N, Watanabe N, Kita N, Bandoh S, Tadokoro A, Ishii T, et al. Paraneoplastic syndromes associated with lung cancer. <em>World J Clin Oncol<\/em> 2014;<strong>5<\/strong>(3):197\u2013223.<\/li>","DOI":"10.5306\/wjco.v5.i3.197"},{"key":"10.12890\/2020_001872_ref2","doi-asserted-by":"crossref","unstructured":"<li>Lo CH, Jen YM, Tsai WC, Chung PY, Kao WY. Rapidly evolving asymptomatic eosinophilia in a patient with lung adenocarcinoma causes cognitive disturbance and respiratory insufficiency: case report. <em>Oncol Lett<\/em> 2013;<strong>5<\/strong>(2):495\u2013498.<\/li>","DOI":"10.3892\/ol.2012.1020"},{"key":"10.12890\/2020_001872_ref3","doi-asserted-by":"crossref","unstructured":"<li>Riesenberg H, Muller F, Gorner M. Leukemoid reaction in a patient with adenocarcinoma of the lung: a case report. <em>J Med Case Rep<\/em> 2012;<strong>6<\/strong>:211.<\/li>","DOI":"10.1186\/1752-1947-6-211"},{"key":"10.12890\/2020_001872_ref4","doi-asserted-by":"crossref","unstructured":"<li>Granger JM, Kontoyiannis DP. Etiology and outcome of extreme leukocytosis in 758 nonhematologic cancer patients: a retrospective, single-institution study. <em>Cancer 2009;<strong>115<\/strong>(17):3919\u20133923.<\/li>","DOI":"10.1002\/cncr.24480"},{"key":"10.12890\/2020_001872_ref5","doi-asserted-by":"crossref","unstructured":"<li>Abughanimeh O, Tahboub M, Abu Ghanimeh M. Metastatic lung adenocarcinoma presenting with hypereosinophilia. <em>Cureus<\/em> 2018;<strong>10<\/strong>(6):e2866.<\/li>","DOI":"10.7759\/cureus.2866"},{"key":"10.12890\/2020_001872_ref6","doi-asserted-by":"crossref","unstructured":"<li>Pandit R, Scholnik A, Wulfekuhler L, Dimitrov N. Non-small-cell lung cancer associated with excessive eosinophilia and secretion of interleukin-5 as a paraneoplastic syndrome. <em>Am J Hematol<\/em> 2007;<strong>82<\/strong>(3):234\u2013237.<\/li>","DOI":"10.1002\/ajh.20789"},{"key":"10.12890\/2020_001872_ref7","doi-asserted-by":"crossref","unstructured":"<li>Klimek M. 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Neutrophilia as prognostic biomarker in locally advanced stage III lung cancer. <em>PLoS One<\/em> 2018;<strong>13<\/strong>(10):e0204490.<\/li>","DOI":"10.1371\/journal.pone.0204490"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1872\/2291","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1872\/2292","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1872\/2292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T13:28:55Z","timestamp":1756474135000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/1872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,14]]},"references-count":9,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.12890\/2020_001872","relation":{"has-manifestation":[{"id-type":"other","id":"1-64-1872-g2291","asserted-by":"subject"},{"id-type":"other","id":"1-64-1872-g2292","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-64","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2020,8,14]]},"article-number":"51"}}