{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:31:40Z","timestamp":1777498300226,"version":"3.51.4"},"reference-count":9,"publisher":"SMC Media","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Spontaneous periodic hypothermia is a rare syndrome presenting with recurrent, centrally mediated hypothermia without an identifiable systemic cause or brain lesion. The case of an 88-year-old woman with recurrent hypothermia is reported. Despite intensive investigation, no other manifestations of hypothalamic or autonomic dysfunction were found. No corpus callosum lesion was seen on MRI. The patient was successfully treated with clomipramine chlorhydrate.<\/jats:p>","DOI":"10.12890\/2020_001874","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:52:37Z","timestamp":1621936357000},"source":"Crossref","is-referenced-by-count":3,"title":["Spontaneous Periodic Hypothermia in the Elderly: A Rare or Under-Recognised Syndrome"],"prefix":"10.12890","volume":"7","author":[{"given":"Hassene","family":"Attout","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, General Hospital, Ales, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Amichi","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, General Hospital, Ales, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youcef","family":"Belkheir","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, General Hospital, Ales, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2020,9,28]]},"reference":[{"key":"10.12890\/2020_001874_ref1","doi-asserted-by":"crossref","unstructured":"<li>Shapiro WR, Williams GH, Plum F. Spontaneous recurrent hypothermia accompanying agenesis of the corpus callosum. <em>Brain<\/em> 1969;<strong>92<\/strong>:423\u2013436. <\/li>","DOI":"10.1093\/brain\/92.2.423"},{"key":"10.12890\/2020_001874_ref2","doi-asserted-by":"crossref","unstructured":"<li>Blondin NA. Diagnosis and management of periodic hypothermia. <em>Neurol Clin Pract<\/em> 2014;<strong>4<\/strong>(1):26\u201332.<\/li>","DOI":"10.1212\/01.CPJ.0000437350.47610.3a"},{"key":"10.12890\/2020_001874_ref3","doi-asserted-by":"crossref","unstructured":"<li>Kloos RT. Spontaneous periodic hypothermia.<em> Medicine (Baltimore)<\/em> 1995;<strong>74<\/strong>(5):268\u2013280.<\/li>","DOI":"10.1097\/00005792-199509000-00004"},{"key":"10.12890\/2020_001874_ref4","doi-asserted-by":"crossref","unstructured":"<li>Bosacki C, Hausfater P, Koenig M, Serratrice J, Piette AM, Cathebras P. Spontaneous hypothermia: a series of ten cases, place of Shapiro\u2019s syndrome. <em>Rev Med Interne<\/em> 2005;<strong>26<\/strong>(8):615\u2013623.<\/li>","DOI":"10.1016\/j.revmed.2005.05.005"},{"key":"10.12890\/2020_001874_ref5","unstructured":"<li>Mayer U, Aigner JM, Klein HE. Hypothermia caused by neuroleptics: 2 case reports and review of the literature. <em>Nervenarzt<\/em> 1994;<strong>65<\/strong>(7):488\u2013491.<\/li>"},{"key":"10.12890\/2020_001874_ref6","doi-asserted-by":"crossref","unstructured":"<li>Hemelsoet DM, De Bleecker JL. Post-traumatic spontaneous recurrent hypothermia: a variant of Shapiro\u2019s syndrome. <em>Eur J Neurol<\/em> 2007;<strong>14<\/strong>(2):224\u2013227.<\/li>","DOI":"10.1111\/j.1468-1331.2006.01609.x"},{"key":"10.12890\/2020_001874_ref7","unstructured":"<li>Walker BR, Anderson JA, Edwards CR. Clonidine therapy for Shapiro\u2019s syndrome. <em>Q J Med<\/em> 1992;<strong>82<\/strong>(299):235\u2013245.<\/li>"},{"key":"10.12890\/2020_001874_ref8","doi-asserted-by":"crossref","unstructured":"<li>Rodrigues MM, Lin J, Arita JH, De Castro Neto EF, Scerni DA, Cavalheiro EA, et al. Spontaneous periodic hypothermia and hyperhidrosis: a possible novel cerebral neurotransmitter disorder. <em>Dev Med Child Neurol<\/em> 2011;<strong>53<\/strong>:378\u2013380. <\/li>","DOI":"10.1111\/j.1469-8749.2010.03854.x"},{"key":"10.12890\/2020_001874_ref9","doi-asserted-by":"crossref","unstructured":"<li>Tambasco N, Belcastro V, Prontera P, Nigro P, Donti E, Rossi A, et al. Shapiro's syndrome: defining the clinical spectrum of the spontaneous paroxysmal hypothermia syndrome. <em>Eur J Paediatr Neurol<\/em> 2014;<strong>18<\/strong>:453\u2013457. <\/li>","DOI":"10.1016\/j.ejpn.2014.02.001"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1874\/2357","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1874\/2359","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1874\/2359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T12:17:42Z","timestamp":1756469862000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/1874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,28]]},"references-count":9,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.12890\/2020_001874","relation":{"has-manifestation":[{"id-type":"other","id":"1-65-1874-g2357","asserted-by":"subject"},{"id-type":"other","id":"1-65-1874-g2359","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-65","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,28]]},"article-number":"45"}}