{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T18:49:43Z","timestamp":1763664583896,"version":"3.44.0"},"reference-count":6,"publisher":"SMC Media","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Objectives:To present a rare case of propofol-induced hepatitis. Materials and methods: A 59-year old man was referred to our department because of suspicion of toxic hepatitis after propofol anaesthesia for endoscopic colonoscopy.\u00a0 Results: The patient had jaundice, increased transaminases demonstrating liver necrosis, and liver stiffness of 18 kPa. Liver biopsy revealed bridging necrosis and initial post-collapse fibrosis. Following therapy with steroids and N-acetyl cysteine, the patient was discharged on the seventh day after admission in good general condition. Conclusion: Although propofol is considered safe, it can cause acute hepatitis, the seventh published case of which is reported here. Importantly, treatment with N-acetyl cysteine, a radical scavenger, but especially with steroids resulted in hepatic improvement.<\/jats:p>","DOI":"10.12890\/2020_001921","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:52:37Z","timestamp":1621936357000},"source":"Crossref","is-referenced-by-count":4,"title":["Propofol-Induced Hepatitis"],"prefix":"10.12890","volume":"7","author":[{"given":"Hanna","family":"Raisi","sequence":"additional","affiliation":[{"name":"Center for Alcohol Research (CAR), University of Heidelberg and Department of Medicine, Salem Medical Center, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Longerich","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo","family":"Moreira Assuncao","sequence":"additional","affiliation":[{"name":"Center for Alcohol Research (CAR), University of Heidelberg and Department of Medicine, Salem Medical Center, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Mueller","sequence":"additional","affiliation":[{"name":"Center for Alcohol Research (CAR), University of Heidelberg and Department of Medicine, Salem Medical Center, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Schirmacher","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut-Karl","family":"Seitz","sequence":"additional","affiliation":[{"name":"Center for Alcohol Research (CAR), University of Heidelberg and Department of Medicine, Salem Medical Center, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2020,10,8]]},"reference":[{"key":"10.12890\/2020_001921_ref1","doi-asserted-by":"crossref","unstructured":"<li>Anand K, Ramsay MA, Crippin JS. Hepatocellular injury following the administration of propofol. <em>Anesthesiology<\/em> 2001;<strong>95<\/strong>(6):1523\u20131524.<\/li>","DOI":"10.1097\/00000542-200112000-00037"},{"key":"10.12890\/2020_001921_ref2","doi-asserted-by":"crossref","unstructured":"<li>Polo-Romero FJ, Paricio P, Tovar A, Alonso JM. Propofol-induced acute toxic hepatitis after brief sedation for endoscopic retrograde cholangiopancreatography. <em>Endoscopy<\/em> 2008;<strong>40<\/strong>(Suppl 2):E49.<\/li>","DOI":"10.1055\/s-2007-966881"},{"key":"10.12890\/2020_001921_ref3","doi-asserted-by":"crossref","unstructured":"<li>Nguyen HD, Borum ML. Acute hepatitis in a patient given propofol during colonoscopy. <em>South Med J<\/em> 2009;<strong>102<\/strong>(3):333\u2013334.<\/li>","DOI":"10.1097\/SMJ.0b013e318191c5ee"},{"key":"10.12890\/2020_001921_ref4","doi-asserted-by":"crossref","unstructured":"<li>Kneiseler G, Bachmann HS, Bechmann LP, Dechene A, Heyer T, Baba H, et al. A rare case of propofol-induced acute liver failure and literature review. <em>Case Rep Gastroenterol<\/em> 2010;<strong>4<\/strong>(1):57\u201365.<\/li>","DOI":"10.1159\/000262448"},{"key":"10.12890\/2020_001921_ref5","doi-asserted-by":"crossref","unstructured":"<li>Rocha-Honor E, Polo-Romero FJ, S\u00e1nchez-Beteta P, Mart\u00ednez-Peguero J, Santisteban-L\u00f3pez Y, Beato-P\u00e9rez JL. Acarbosa y propofol: \u00bfuna peligrosa combinaci\u00f3n? <em>Rev Esp Anestesiol Reanim<\/em> 2014;<strong>61<\/strong>(2):109\u2013111.<\/li>","DOI":"10.1016\/j.redar.2012.11.003"},{"key":"10.12890\/2020_001921_ref6","doi-asserted-by":"crossref","unstructured":"<li>Asai A, Yagi M, Tsuchimoto Y, Fukunishi S, Takeshita A, Tsuda Y, et al. A rare case of propofol-induced liver injury during modified electroconvulsive therapy in an elderly woman. <em>Intern Med<\/em> 2013;<strong>52<\/strong>(7):761\u2013765.<\/li>","DOI":"10.2169\/internalmedicine.52.9089"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1921\/2374","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1921\/2375","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1921\/2375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T12:17:27Z","timestamp":1756469847000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/1921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,8]]},"references-count":6,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.12890\/2020_001921","relation":{"has-manifestation":[{"id-type":"other","id":"1-65-1921-g2374","asserted-by":"subject"},{"id-type":"other","id":"1-65-1921-g2375","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-65","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2020,10,8]]},"article-number":"37"}}