{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T14:10:02Z","timestamp":1756476602366,"version":"3.44.0"},"reference-count":9,"publisher":"SMC Media","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Tracheobronchopathia osteochondroplastica (TBPO) is an uncommon benign disease, characterized by osseous or metaplastic cartilaginous nodules in the submucosa of the tracheobronchial tree. TBPO is easy to misdiagnose due to its non-specific clinical manifestation. We describe two cases of TBPO. The first patient was a 57-year-old woman with nocturnal dry cough and wheezing, in whom bronchoscopy revealed small diffuse mucosal irregularities involving the airway until the segmental bronchi. The other patient was a 69-year-old man with progressive worsening dyspnoea and productive cough presenting with severe stenosis of the trachea. Histological examination of both cases was consistent with TBPO. These cases highlight distinct forms of presentation of this rare entity.<\/jats:p>","DOI":"10.12890\/2020_001925","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:52:37Z","timestamp":1621936357000},"source":"Crossref","is-referenced-by-count":1,"title":["Tracheobronchopathia Osteochondroplastica: Two Different Facets of a Rare Entity"],"prefix":"10.12890","volume":"7","author":[{"given":"Margarida","family":"Barata","sequence":"additional","affiliation":[{"name":"Pulmonology Department, Hospital Garcia de Orta, Almada, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Gomes","sequence":"additional","affiliation":[{"name":"Pulmonology Department, Hospital Garcia de Orta, Almada, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Catarina","family":"Moreira","sequence":"additional","affiliation":[{"name":"Pulmonology Department, Hospital Garcia de Orta, Almada, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Soares","sequence":"additional","affiliation":[{"name":"Pulmonology Department, Hospital Garcia de Orta, Almada, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"10.12890\/2020_001925_ref1","unstructured":"<li>Lazor R, Cordier JF. Tracheobronchopathia osteochondroplastica. Orphanet Encyclopedia, June 2004. Available at: https:\/\/www.orpha.net\/data\/patho\/GB\/uk-TO.pdf (accessed 4 August 2020).<\/li>"},{"key":"10.12890\/2020_001925_ref2","doi-asserted-by":"crossref","unstructured":"<li> Leske V, Lazor R, Coetmeur D, Crestani B, Chatte G, Cordier JF. Tracheobronchopathia osteochondroplastica: a study of 41 patients. <em>Medicine<\/em> 2001;<strong>80<\/strong>(6):378\u2013390.<\/li>","DOI":"10.1097\/00005792-200111000-00004"},{"key":"10.12890\/2020_001925_ref3","doi-asserted-by":"crossref","unstructured":"<li>Lundgren R, Stjernberg NL. Tracheobronchopathia osteochondroplastica. A clinical bronchoscopic and spirometric study. <em>Chest<\/em> 1981;<strong>80<\/strong>:706\u2013709.<\/li>","DOI":"10.1378\/chest.80.6.706"},{"key":"10.12890\/2020_001925_ref4","doi-asserted-by":"crossref","unstructured":"<li>Ulasli SS, Kupeli E. Tracheobronchopathia osteochondroplastica: a review of the literature.<em> Clin Respir J<\/em> 2015;<strong>9<\/strong>(4):386\u2013391.<\/li>","DOI":"10.1111\/crj.12166"},{"key":"10.12890\/2020_001925_ref5","unstructured":"<li>Wilks S. Ossific deposits on larynx, trachea, and bronchi. <em>Trans Pathol Soc London<\/em> 1857;<strong>8<\/strong>:88.<\/li>"},{"key":"10.12890\/2020_001925_ref6","doi-asserted-by":"crossref","unstructured":"<li>Tukiainen H, Torkko M, Terho EO. Lung function in patients with tracheobronchopathia osteochondroplastica. <em>Eur Resp J<\/em> 1988;<strong>1<\/strong>(7):632\u2013635.<\/li>","DOI":"10.1183\/09031936.93.01070632"},{"key":"10.12890\/2020_001925_ref7","doi-asserted-by":"crossref","unstructured":"<li>Sun J, Xie L, Su X, Zhang X. Tracheobronchopathia osteochondroplastica: case report and literature review. <em>Resp Med Case Rep<\/em> 2015;<strong>15<\/strong>:14\u201317.<\/li>","DOI":"10.1016\/j.rmcr.2015.03.003"},{"key":"10.12890\/2020_001925_ref8","doi-asserted-by":"crossref","unstructured":"<li>Devajara K, Sagar P, Chirom AS. Tracheobronchopathia osteochondroplastica: awareness is the key for diagnosis and management. <em>BMJ Case Rep<\/em> 2017:bcr-2017-220567.<\/li>","DOI":"10.1136\/bcr-2017-220567"},{"key":"10.12890\/2020_001925_ref9","doi-asserted-by":"crossref","unstructured":"<li>Freitag L, Darwich K. Endoscopic treatment of tracheal stenosis. <em>Thorac Surg Clin <\/em>2014;<strong>4<\/strong>:27\u201340. <\/li>","DOI":"10.1016\/j.thorsurg.2013.10.003"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1925\/2313","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1925\/2314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1925\/2314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T13:28:42Z","timestamp":1756474122000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/1925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,28]]},"references-count":9,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.12890\/2020_001925","relation":{"has-manifestation":[{"id-type":"other","id":"1-64-1925-g2313","asserted-by":"subject"},{"id-type":"other","id":"1-64-1925-g2314","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-64","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2020,8,28]]},"article-number":"46"}}