{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T12:40:04Z","timestamp":1756471204493,"version":"3.44.0"},"reference-count":20,"publisher":"SMC Media","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Acute pancreatitis (AP) remains one of the most common causes of emergency department visits in the USA. The literature supports an association between angiotensin-converting enzyme inhibitors (ACEi), mainly at steady-state doses, and AP. We present a case of recurrent AP and pseudocyst formation following multiple ACEi dose adjustments after a steady-state period lasting for over a decade. Previous reports have rarely described ACEi-induced pancreatitis and pseudocyst development. ACEi can cause significant ductal obstruction and fluid retention due to its angioedema effects. Consequently, it may trigger AP complicated by pseudocyst formation. Therefore, ACEi administration must be considered in the appropriate clinical context.<\/jats:p>","DOI":"10.12890\/2020_001956","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:52:37Z","timestamp":1621936357000},"source":"Crossref","is-referenced-by-count":5,"title":["Angiotensin-Converting Enzyme (ACE) Inhibitors and Pancreatitis: A Potential Dose-dependent Relationship"],"prefix":"10.12890","volume":"7","author":[{"given":"Murtaza","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Michigan State University at Hurley Medical Center, Flint, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smit S","family":"Deliwala","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Michigan State University at Hurley Medical Center, Flint, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anoosha","family":"Ponnapalli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Michigan State University at Hurley Medical Center, Flint, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viraj","family":"Modi","sequence":"additional","affiliation":[{"name":"New York Institute of Technology College of Osteopathic Medicine, Glen Head, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Kanugula","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Michigan State University at Hurley Medical Center, Flint, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoon M","family":"Elbedawi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u2013 Division of Gastroenterology, Michigan State University at Hurley Medical Center, Flint, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghassan","family":"Bachuwa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Michigan State University at Hurley Medical Center, Flint, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"10.12890\/2020_001956_ref1","doi-asserted-by":"crossref","unstructured":"<li>Thumma S, Errico K, Manchala V, Mattana J. 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Simultaneous acute pancreatitis and angioedema associated with angiotensin-converting enzyme inhibitor. <em>Saudi J Kidney Dis Transpl<\/em> 2019;<strong>30<\/strong>6):1479\u20131484.<\/li>","DOI":"10.4103\/1319-2442.275498"},{"key":"10.12890\/2020_001956_ref12","doi-asserted-by":"crossref","unstructured":"<li>Bouffard L, Papirakis M-E, Maheux P. Enalapril increases the local extravasation of macromolecules and nitric oxide synthase in pancreas of the fructose-fed insulin-resistant rat model. <em>Pancreas <\/em>2006;<strong>33<\/strong>(4):418\u2013424.<\/li>","DOI":"10.1097\/01.mpa.0000236729.01123.7d"},{"key":"10.12890\/2020_001956_ref13","unstructured":"<li>Jones MR, Hall OM, Kaye AM, Kaye AD. Drug-induced acute pancreatitis: a review. <em>Ochsner J<\/em> 2015;<strong>15<\/strong>(1):45\u201351.<\/li>"},{"key":"10.12890\/2020_001956_ref14","doi-asserted-by":"crossref","unstructured":"<li>Brown KV, Khan AZ, Paterson IM. 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Pancreatic pseudocyst. <em>World J Gastroenterol<\/em> 2009;<strong>15<\/strong>(1):38.<\/li>","DOI":"10.3748\/wjg.15.38"},{"key":"10.12890\/2020_001956_ref18","doi-asserted-by":"crossref","unstructured":"<li>Anagnostopoulos GK, Kostopoulos P, Tsiakos S, Margantinis G, Arvanitidis D. Fulminant pancreatitis associated with ramipril therapy. <em>Pancreas<\/em> 2003;<strong>27<\/strong>(3):278\u2013279.<\/li>","DOI":"10.1097\/00006676-200310000-00017"},{"key":"10.12890\/2020_001956_ref19","doi-asserted-by":"crossref","unstructured":"<li>Standridge JB. Fulminant pancreatitis associated with lisinopril therapy. <em>South Med J<\/em> 1994;<strong>87<\/strong>(2):179\u2013181.<\/li>","DOI":"10.1097\/00007611-199402000-00005"},{"key":"10.12890\/2020_001956_ref20","doi-asserted-by":"crossref","unstructured":"<li>Bexelius TS, Ljung R, Mattsson F, Lu Y, Lindblad M. Angiotensin II receptor blockers and risk of acute pancreatitis-a population based case\u2013control study in Sweden. <em>BMC Gastroenterol<\/em> 2017;<strong>17<\/strong>(1):36.<\/li>","DOI":"10.1186\/s12876-017-0595-8"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1956\/2420","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1956\/2421","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1956\/2421","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T12:17:11Z","timestamp":1756469831000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/1956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,28]]},"references-count":20,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.12890\/2020_001956","relation":{"has-manifestation":[{"id-type":"other","id":"1-65-1956-g2420","asserted-by":"subject"},{"id-type":"other","id":"1-65-1956-g2421","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-65","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2020,10,28]]},"article-number":"41"}}