{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T12:40:04Z","timestamp":1756471204889,"version":"3.44.0"},"reference-count":5,"publisher":"SMC Media","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Hyperemesis gravidarum (HG) is a complication mainly of the first trimester of pregnancy, which sometimes leads to metabolic disorders such as hypovolemia and acute kidney injury (AKI). Herein, we present the case of a 25-year-old woman at week 10 of gestation who exhibited a constellation ofsevere abnormalities, namely AKI (serum creatinine 6.15 mg\/dl), transaminasemia (serum aminotransferases &gt;1,000 IU\/l), alkalemia (arterial pH7.667), hyponatremia (serum sodium 117 mEq\/l), hypochloremia (serum chloride 54 mEq\/l),hypokalemia (serum potassium 2.2 mEq\/l) and hyperuricemia (serum uric acid 20 mg\/dl). Despite a thorough work-up, no other disorder was found apart from HG. All symptoms and metabolic abnormalities resolved with targeted administration of intravenous fluids. The differential diagnosis of these disorders and therapeutic challenges are discussed.<\/jats:p>","DOI":"10.12890\/2020_001979","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:52:37Z","timestamp":1621936357000},"source":"Crossref","is-referenced-by-count":0,"title":["Hyperemesis Gravidarum: A Benign Condition of Pregnancy or a Challenging Metabolic Disorder?"],"prefix":"10.12890","volume":"7","author":[{"given":"Matilda","family":"Florentin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Parthymos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aris","family":"Agouridis","sequence":"additional","affiliation":[{"name":"School of Medicine, European University Cyprus, Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Liamis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"key":"10.12890\/2020_001979_ref1","doi-asserted-by":"crossref","unstructured":"<li>Erick M, Cox JT, Mogensen KM.ACOG Practice Bulletin No. 189: nausea and vomiting of pregnancy. <em>Obstet Gynecol<\/em> 2018;<strong>131<\/strong>(5):935.<\/li>","DOI":"10.1097\/AOG.0000000000002604"},{"key":"10.12890\/2020_001979_ref2","doi-asserted-by":"crossref","unstructured":"<li>London V, Grube S, Sherer DM, Abulafia O.Hyperemesis gravidarum: a review of recent literature. <em>Pharmacology<\/em> 2017;<strong>100<\/strong>(3\u20134):161\u2013171.<\/li>","DOI":"10.1159\/000477853"},{"key":"10.12890\/2020_001979_ref3","doi-asserted-by":"crossref","unstructured":"<li>Korman JD, Volenberg I, Balko J, Webster J, Schiodt FV, Squires RH, et al.Screening for Wilson disease in acute liver failure: a comparison of currently available diagnostic tests. <em>Hepatology<\/em> 2008;<strong>48<\/strong>(4):1167\u20131174.<\/li>","DOI":"10.1002\/hep.22446"},{"key":"10.12890\/2020_001979_ref4","doi-asserted-by":"crossref","unstructured":"<li>Lee NM,Brady CW.Liver disease in pregnancy. <em>World J Gastroenterol <\/em>2009;<strong>15<\/strong>(8):897\u2013906.<\/li>","DOI":"10.3748\/wjg.15.897"},{"key":"10.12890\/2020_001979_ref5","doi-asserted-by":"crossref","unstructured":"<li>Conchillo JM, Koek GH. Hyperemesis gravidarum and severe liver enzyme elevation. <em>J Hepatol<\/em> 2002;<strong>37<\/strong>(1):162\u2013163.<\/li>","DOI":"10.1016\/S0168-8278(02)00089-2"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1979\/2400","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1979\/2401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1979\/2401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T12:17:20Z","timestamp":1756469840000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/1979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,16]]},"references-count":5,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.12890\/2020_001979","relation":{"has-manifestation":[{"id-type":"other","id":"1-65-1979-g2400","asserted-by":"subject"},{"id-type":"other","id":"1-65-1979-g2401","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-65","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2020,10,16]]},"article-number":"32"}}