{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T07:25:07Z","timestamp":1767597907090,"version":"3.44.0"},"reference-count":6,"publisher":"SMC Media","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Portal vein thrombosis (PVT) is an uncommon finding in patients without cirrhosis. The underlying aetiology is challenging and the condition has a wide differential diagnosis. We present a case of PVT in an anaemic patient with chronic iron and folic acid deficiency masking underlying polycythemia vera (PV). Only a careful review of the patient\u2019s clinical history allowed the identification of a short period of laboratory erythrocytosis, 6 months before the clinical onset of PVT, while the patient was on iron and folic acid supplementation. The finding raised clinical suspicion of PV previously masked by iron deficiency anaemia. Subsequent investigation confirmed the presence of the JAK2 V617F mutation and, ultimately, showed that the patient met all diagnostic criteria for PV. Myeloproliferative disorders (MPD) are associated with systemic prothrombotic states. PV is distinguished clinically from other MPD by the presence of increased red blood cell mass. Moreover, patients with abnormal haematocrit values in the pre-JAK2 V617F era may have had occult or latent PV. Diagnosis confirmation requires a combination of major and minor criteria to capture occasional cases of occult PV. This case emphasizes the importance of always considering MPD in the aetiological investigation of PVT, even in patients who apparently do not fulfil the diagnostic criteria.<\/jats:p>","DOI":"10.12890\/2020_002003","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:52:37Z","timestamp":1621936357000},"source":"Crossref","is-referenced-by-count":1,"title":["Portal Vein Thrombosis Secondary to Occult Polycythemia Vera"],"prefix":"10.12890","volume":"7","author":[{"given":"Ant\u00f3n FR","family":"Gameiro","sequence":"additional","affiliation":[{"name":"Hospital do SAMS, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9384-7080","authenticated-orcid":false,"given":"Ant\u00f3nio","family":"Robalo Nunes","sequence":"additional","affiliation":[{"name":"Hospital do SAMS, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Guerra","sequence":"additional","affiliation":[{"name":"Hospital do SAMS, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estela","family":"Mateus","sequence":"additional","affiliation":[{"name":"Hospital do SAMS, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1tima","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Hospital do SAMS, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2020,11,2]]},"reference":[{"key":"10.12890\/2020_002003_ref1","doi-asserted-by":"crossref","unstructured":"<li>Michiels JJ. Erythromelalgia and vascular complications in polycythemia vera. Semin <em>Thromb Hemost<\/em> 1997;<strong>23<\/strong>:441\u2013454.<\/li>","DOI":"10.1055\/s-2007-996121"},{"key":"10.12890\/2020_002003_ref2","doi-asserted-by":"crossref","unstructured":"<li>Tefferi A, Barbui T. Polycythemia vera and essential thrombocythemia: 2019 update on diagnosis, risk-stratification and management. <em>Am J Hematol<\/em> 2019;<strong>94<\/strong>(1):133\u2013143.<\/li>","DOI":"10.1002\/ajh.25303"},{"key":"10.12890\/2020_002003_ref3","doi-asserted-by":"crossref","unstructured":"<li>Trebicka J, Strassburg CP. Etiology and complications of portal vein thrombosis. <em>Viszeralmedizin<\/em> 2014;<strong>30<\/strong>:375\u2013380.<\/li>","DOI":"10.1159\/000369987"},{"key":"10.12890\/2020_002003_ref4","doi-asserted-by":"crossref","unstructured":"<li>Ginzburg YZ, Feola M, Zimran E, Varkonyi J, Ganz T, Hoffman R. Dysregulated iron metabolism in polycythemia vera: etiology and consequences. <em>Leukemia<\/em> 2018;<strong>32<\/strong>:2105\u20132116.<\/li>","DOI":"10.1038\/s41375-018-0207-9"},{"key":"10.12890\/2020_002003_ref5","doi-asserted-by":"crossref","unstructured":"<li>Kambali S, Taj A. Polycythemia vera masked due to severe iron deficiency anemia. <em>Hematol Oncol Stem Cell Ther<\/em> 2018;<strong>11<\/strong>(1):38\u201340.<\/li>","DOI":"10.1016\/j.hemonc.2016.08.007"},{"key":"10.12890\/2020_002003_ref6","doi-asserted-by":"crossref","unstructured":"<li>Dentali F, Squizzato A, Brivio L, Appio L, Campiotti L, Crowther M, et al. JAK2V617F mutation for the early diagnosis of Ph\u2013 myeloproliferative neoplasms in patients with venous thromboembolism: a meta-analysis. <em>Blood<\/em> 2009;<strong>113<\/strong>:5617\u20135623.<\/li>","DOI":"10.1182\/blood-2008-12-196014"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2003\/2426","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2003\/2427","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2003\/2427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T12:17:02Z","timestamp":1756469822000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/2003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,2]]},"references-count":6,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.12890\/2020_002003","relation":{"has-manifestation":[{"id-type":"other","id":"1-65-2003-g2426","asserted-by":"subject"},{"id-type":"other","id":"1-65-2003-g2427","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-65","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2020,11,2]]},"article-number":"38"}}