{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:01:44Z","timestamp":1760101304443,"version":"3.44.0"},"reference-count":11,"publisher":"SMC Media","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Pleuroparenchymal fibroelastosis (PPFE) is a relatively rare interstitial lung disease (ILD) consisting of elastofibrosis involving the subpleural parenchyma and visceral pleura with an upper lobe predominance. It can be idiopathic or associated with some forms of autoimmune disease. The authors describe the case of a 78-year-old woman with a previous diagnosis of Crohn\u2019s disease (CD). She presented with a protracted respiratory infection (with no significant history of previous infections), and underwent high-resolution chest computerized tomography that eventually showed alterations compatible with PPFE. After exclusion of other possible underlying causes, a possible link to CD was considered. Follow-up investigation at 12 months showed clinical and radiological stability and also stable lung function under treatment with hydroxychloroquine and prednisolone. This is the first report of PPFE in the context of CD. Future studies will be important to further investigate this pathological association and its prognostic implications.<\/jats:p>","DOI":"10.12890\/2020_002017","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:52:37Z","timestamp":1621936357000},"source":"Crossref","is-referenced-by-count":2,"title":["Pleuroparenchymal Fibroelastosis Associated with Crohn\u2019s Disease: A New Aetiology?"],"prefix":"10.12890","volume":"7","author":[{"given":"Carolina","family":"Amado","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Gon\u00e7alo Ferreira","sequence":"additional","affiliation":[{"name":"Pulmonology Department, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2020,11,25]]},"reference":[{"key":"10.12890\/2020_002017_ref1","doi-asserted-by":"crossref","unstructured":"<li> Chua F, Desai SR, Nicholson AG, Devaraj A, Renzoni E, Rice A, et al. Pleuroparenchymal fibroelastosis \u2013 a review of clinical, radiological, and pathological characteristics. <em>Ann Am Thorac Soc<\/em> 2019;<strong>6<\/strong>(11):1351\u20131359.<\/li>","DOI":"10.1513\/AnnalsATS.201902-181CME"},{"key":"10.12890\/2020_002017_ref2","doi-asserted-by":"crossref","unstructured":"<li> Martins CT, Gon\u00e7alves JR. Fronteiras do pulm\u00e3o \u2013 rela\u00e7\u00e3o com o sistema gastroenterol\u00f3gico. <em>Rev Port Pneumol<\/em> 2020;16(1).<\/li>","DOI":"10.1016\/S0873-2159(15)30011-8"},{"key":"10.12890\/2020_002017_ref3","doi-asserted-by":"crossref","unstructured":"<li> Mahadeva R, Walsh G, Flower CDR, Shneerson JM. Clinical and radiologic characteristics of lung disease in inflammatory bowel disease. <em>Eur Respir J<\/em> 2000;<strong>15<\/strong>:41\u201348.<\/li>","DOI":"10.1183\/09031936.00.15104100"},{"key":"10.12890\/2020_002017_ref4","doi-asserted-by":"crossref","unstructured":"<li> Majewski S. Pulmonary manifestations of inflammatory bowel disease. <em>Arch Med Sci<\/em> 2015;<strong>11<\/strong>(6):1179\u20131188.<\/li>","DOI":"10.5114\/aoms.2015.56343"},{"key":"10.12890\/2020_002017_ref5","doi-asserted-by":"crossref","unstructured":"<li> Yilmaz A, Demirci NY, Ho?g\u00fcn D, \u00dcner E, Erdo?an Y, G\u00f6k\u00e7ek A, et al. Pulmonary involvement in inflammatory bowel disease. <em>World J Gastroenterol<\/em> 2010;<strong>16<\/strong>(39):4952\u20134957.<\/li>","DOI":"10.3748\/wjg.v16.i39.4952"},{"key":"10.12890\/2020_002017_ref6","unstructured":"<li> Singh R, Sundaram P, Joshi JM. Upper lobe fibrosis in ulcerative colitis. <em>J Assoc Physicians India<\/em> 2003;<strong>51<\/strong>:515\u2013517.<\/li>"},{"key":"10.12890\/2020_002017_ref7","doi-asserted-by":"crossref","unstructured":"<li> Kinoshita Y, Watanabe K, Ishii H, Kushima H, Hamasaki M, Fujita M, et al. 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