{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:50:11Z","timestamp":1790747411907,"version":"4.1.0"},"reference-count":11,"publisher":"SMC Media","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Crimean-Congo haemorrhagic fever (CCHF) is a lethal zoonotic disease caused by an RNA virus that is a member of the Nairovirus genus in the Bunyaviridae family from the arbovirus group. CCHF is transmitted by Hyalomma ticks through direct contact with the blood and other bodily fluids of patients or infected animals. Case description: A 65-year-old man was admitted to the emergency unit with dry cough, myalgia and fever. He was treated with favipiravir. He had disseminated intravascular coagulopathy with thrombocytopenia in the setting of COVID-19 infection. He tested positive for both COVID-19 and CCHF. By the end of the fifth day of treatment, his laboratory parameters and clinical symptoms had normalized. Conclusion: Favipiravir is currently on the market for treating COVID-19 infection worldwide. It has also been used to treat CCHF in laboratory animals. To the best of our knowledge this is the first report of CCHF successfully treated with favipiravir, which could be a key drug for treating human CCHF.<\/jats:p>","DOI":"10.12890\/2020_002042","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:52:37Z","timestamp":1621936357000},"source":"Crossref","is-referenced-by-count":6,"title":["Treatment of Crimean-Congo Haemorrhagic Fever by Favipiravir in a Patient with Novel Coronavirus Co-Infection"],"prefix":"10.12890","volume":"7","author":[{"given":"Ahmet Cumhur","family":"D\u00fclger","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Giresun State Hospital Affiliated to Giresun University,Giresun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Yakari\u015fik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Giresun State Hospital Affiliated to Giresun University,Giresun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf Emre","family":"Uzun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dereli State Hospital, Giresun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Melih","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Giresun State Hospital Affiliated to Giresun University, Giresun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10397","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"key":"10.12890\/2020_002042_ref1","doi-asserted-by":"crossref","unstructured":"<li>Shayan S, Bokaean M, Shahrivar MR, Chinikar S. 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Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase. <em>Proc Jpn Acad Ser B Phys Biol Sci<\/em> 2017;<strong>93<\/strong>(7):449\u2013463.<\/li>","DOI":"10.2183\/pjab.93.027"},{"key":"10.12890\/2020_002042_ref5","doi-asserted-by":"crossref","unstructured":"<li>Delang L, Abdelnabi R, Neyts J. Favipiravir as a potential countermeasure against neglected and emerging RNA viruses. <em>Antivir Res<\/em> 2018;<strong>153<\/strong>:85\u201394.<\/li>","DOI":"10.1016\/j.antiviral.2018.03.003"},{"key":"10.12890\/2020_002042_ref6","doi-asserted-by":"crossref","unstructured":"<li>Acter T, Uddin N, Das J, Akhter A, Choudhury TR, Kim S. Evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as coronavirus disease 2019 (COVID-19) pandemic: a global health emergency. <em>Sci Total Environ<\/em> 2020;<strong>730<\/strong>:138996.<\/li>","DOI":"10.1016\/j.scitotenv.2020.138996"},{"key":"10.12890\/2020_002042_ref7","doi-asserted-by":"crossref","unstructured":"<li>Hawman DW, Feldmann H. Recent advances in understanding Crimean-Congo hemorrhagic fever virus. <em>F1000Res<\/em> 2018;<strong>7<\/strong>:F1000 Faculty Rev-1715.<\/li>","DOI":"10.12688\/f1000research.16189.1"},{"key":"10.12890\/2020_002042_ref8","doi-asserted-by":"crossref","unstructured":"<li>Sas MA, Vina-Rodriguez A, Mertens M, Eiden M, Emmerich P, Chaintoutis SC, et al. A one-step multiplex real-time RT-PCR for the universal detection of all currently known CCHFV genotypes. <em>J Virol Methods<\/em> 2018;<strong>255<\/strong>:38\u201343.<\/li>","DOI":"10.1016\/j.jviromet.2018.01.013"},{"key":"10.12890\/2020_002042_ref9","doi-asserted-by":"crossref","unstructured":"<li>Zhang J, Xie B, Hashimoto K. Current status of potential therapeutic candidates for the COVID-19 crisis. <em>Brain Behav Immun<\/em> 2020;<strong>87<\/strong>:59\u201373.<\/li>","DOI":"10.1016\/j.bbi.2020.04.046"},{"key":"10.12890\/2020_002042_ref10","doi-asserted-by":"crossref","unstructured":"<li>Oestereich L, Rieger T, Neumann M, Bernreuther C, Lehmann M, Krasemann S, et al. Evaluation of antiviral efficacy of ribavirin, arbidol, and T-705 (favipiravir) in a mouse model for Crimean-Congo hemorrhagic fever. <em>PLoS Negl Trop Dis<\/em> 2014;<strong>8<\/strong>(5):e2804.<\/li>","DOI":"10.1371\/journal.pntd.0002804"},{"key":"10.12890\/2020_002042_ref11","doi-asserted-by":"crossref","unstructured":"<li>Hawman DW, Haddock E, Meade-White K, Williamson B, Hanley PW, Rosenke K, et al. Favipiravir (T-705) but not ribavirin is effective against two distinct strains of Crimean-Congo hemorrhagic fever virus in mice. <em>Antivir Res<\/em> 2018;<strong>157<\/strong>:18\u201326.<\/li>","DOI":"10.1016\/j.antiviral.2018.06.013"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2042\/2490","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2042\/2491","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2042\/2491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T12:15:59Z","timestamp":1756469759000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/2042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,17]]},"references-count":11,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.12890\/2020_002042","relation":{"has-manifestation":[{"id-type":"other","id":"1-65-2042-g2490","asserted-by":"subject"},{"id-type":"other","id":"1-65-2042-g2491","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-65","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,17]]},"article-number":"12"}}