{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:03:55Z","timestamp":1783350235477,"version":"3.54.6"},"reference-count":6,"publisher":"SMC Media","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Ceftriaxone is a widely used antibiotic regarded as safe and effective. Drug-induced agranulocytosis is a life-threatening adverse reaction and few reports related to ceftriaxone were found in a review of the literature. The authors present a case of ceftriaxone-induced agranulocytosis, in which a brain abscess was diagnosed and ceftriaxone was commenced. Neutropenic fever occurred on the 29th day of therapy with a cumulative dose of 116 g ceftriaxone and a neutrophil nadir of 0.1\u00d7109\/l. Ceftriaxone was withheld, filgrastim was administered for 3 days and neutrophil normalization was achieved. Although rare, ceftriaxone-induced agranulocytosis may occur in patients on a long course of ceftriaxone therapy. Prompt recognition and drug withdrawal are required.<\/jats:p>","DOI":"10.12890\/2021_002215","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:52:37Z","timestamp":1621936357000},"source":"Crossref","is-referenced-by-count":3,"title":["Ceftriaxone-induced Agranulocytosis"],"prefix":"10.12890","volume":"8","author":[{"given":"L\u00e9nio","family":"Couto","sequence":"additional","affiliation":[{"name":"Hospital de Santo Esp\u00edrito da Ilha Terceira, Angra do Hero\u00edsmo, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Goulart","sequence":"additional","affiliation":[{"name":"Hospital de Santo Esp\u00edrito da Ilha Terceira, Angra do Hero\u00edsmo, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivone","family":"Valad\u00e3o","sequence":"additional","affiliation":[{"name":"Hospital de Santo Esp\u00edrito da Ilha Terceira, Angra do Hero\u00edsmo, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Gar\u00e7a","sequence":"additional","affiliation":[{"name":"Hospital de Santo Esp\u00edrito da Ilha Terceira, Angra do Hero\u00edsmo, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Beatriz","family":"Santos","sequence":"additional","affiliation":[{"name":"Hospital de Santo Esp\u00edrito da Ilha Terceira, Angra do Hero\u00edsmo, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Cota","sequence":"additional","affiliation":[{"name":"Hospital de Santo Esp\u00edrito da Ilha Terceira, Angra do Hero\u00edsmo, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Hospital de Santo Esp\u00edrito da Ilha Terceira, Angra do Hero\u00edsmo, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10397","published-online":{"date-parts":[[2021,1,8]]},"reference":[{"key":"10.12890\/2021_002215_ref1","doi-asserted-by":"crossref","unstructured":"<li>Sileshi A, Tenna A, Feyissa M, Shibeshi W. Evaluation of ceftriaxone utilization in medical and emergency wards of Tikur Anbessa specialized hospital: a prospective cross-sectional study. <em>BMC Pharmacol Toxicol<\/em> 2016;<strong>17<\/strong>:7.<\/li>","DOI":"10.1186\/s40360-016-0057-x"},{"key":"10.12890\/2021_002215_ref2","doi-asserted-by":"crossref","unstructured":"<li>Andersohn F, Konzen C, Garbe E. Systematic review: agranulocytosis induced by nonchemotherapy drugs. <em>Ann Intern Med<\/em> 2017;<strong>146<\/strong>(9):657\u2013665.<\/li>","DOI":"10.7326\/0003-4819-146-9-200705010-00009"},{"key":"10.12890\/2021_002215_ref3","doi-asserted-by":"crossref","unstructured":"<li>Mintzer DM, Billet SN, Chmielewski L. Drug-induced hematologic syndromes. <em>Adv Hematol<\/em> 2009;<strong>2009<\/strong>:495863.<\/li>","DOI":"10.1155\/2009\/495863"},{"key":"10.12890\/2021_002215_ref4","doi-asserted-by":"crossref","unstructured":"<li>Andr\u00e8s E, Federici L, Weitten T, Vogel T, Alt M. Recognition and management of drug-induced blood cytopenias: the example of drug-induced acute neutropenia and agranulocytosis. <em>Expert Opin Drug Saf<\/em> 2008;<strong>7<\/strong>(4):481\u2013489.<\/li>","DOI":"10.1517\/14740338.7.4.481"},{"key":"10.12890\/2021_002215_ref5","doi-asserted-by":"crossref","unstructured":"<li>Neftel KA, Hauser SP, M\u00fcller MR. Inhibition of granulopoiesis in vivo and in vitro by ?-lactam antibiotics. <em>J Infect Dis<\/em> 1985;<strong>152<\/strong>(1):90\u201398.<\/li>","DOI":"10.1093\/infdis\/152.1.90"},{"key":"10.12890\/2021_002215_ref6","doi-asserted-by":"crossref","unstructured":"<li>Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. <em>Clin Pharmacol Ther<\/em> 1981;<strong>30<\/strong>(2):239\u2013245<\/li>","DOI":"10.1038\/clpt.1981.154"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2215\/2510","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2215\/2511","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2215\/2511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:30:15Z","timestamp":1756377015000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/2215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,8]]},"references-count":6,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.12890\/2021_002215","relation":{"has-manifestation":[{"id-type":"other","id":"1-66-2215-g2510","asserted-by":"subject"},{"id-type":"other","id":"1-66-2215-g2511","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-66","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,8]]},"article-number":"19"}}