{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T16:50:18Z","timestamp":1766767818685,"version":"3.44.0"},"reference-count":5,"publisher":"SMC Media","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Kounis syndrome (KS) is defined as acute coronary syndrome (ACS) triggered by mast cell and platelet activation in the setting of allergic or anaphylactic insults. KS is a unique and complex cause of ACS and many cases may be missed due to its highly variable clinical manifestations. In this report, we present a case of KS type I triggered by metamizole in the absence of a previous history of allergy to this drug. Following the administration of metamizole, the patient developed generalized acute urticaria, chest pain and diaphoresis. Electrocardiography (ECG) showed ST-segment elevation suggestive of myocardial infarction complicated by ventricular tachycardia. No coronary disease was observed on coronary angiography. The cardiac manifestations of KS may be life-threatening, and so it is important to appropriately recognize and treat this condition.<\/jats:p>","DOI":"10.12890\/2021_002249","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:52:37Z","timestamp":1621936357000},"source":"Crossref","is-referenced-by-count":3,"title":["Metamizole-Induced Type I Kounis Syndrome"],"prefix":"10.12890","volume":"8","author":[{"given":"Catarina","family":"Lameiras","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Professor Doutor Fernando Fonseca EPE, Amadora, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Corte-Real","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Professor Doutor Fernando Fonseca EPE, Amadora, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"\u00d3rf\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Professor Doutor Fernando Fonseca EPE, Amadora, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Mendes Lopes","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Professor Doutor Fernando Fonseca EPE, Amadora, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria do C\u00e9u","family":"D\u00f3ria","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Professor Doutor Fernando Fonseca EPE, Amadora, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2021,2,8]]},"reference":[{"key":"10.12890\/2021_002249_ref1","doi-asserted-by":"crossref","unstructured":"<li>Kounis NG. Kounis syndrome: an update on epidemiology, pathogenesis, diagnosis and therapeutic management. <em>Clin Chem Lab Med<\/em> 2016;<strong>54<\/strong>(10):1545\u20131559.<\/li>","DOI":"10.1515\/cclm-2016-0010"},{"key":"10.12890\/2021_002249_ref2","doi-asserted-by":"crossref","unstructured":"<li>Abdelghany M, Subedi R, Shah S, Kozman H. Kounis syndrome: a review article on epidemiology, diagnostic findings, management and complications of allergic acute coronary syndrome. <em>Int J Cardiol<\/em> 2017;<strong>232<\/strong>:1\u20134.<\/li>","DOI":"10.1016\/j.ijcard.2017.01.124"},{"key":"10.12890\/2021_002249_ref3","doi-asserted-by":"crossref","unstructured":"<li>K\u00f6tter T, da Costa BR, F\u00e4ssler M, Blozik E, Linde K, J\u00fcni P, et al. Metamizole-associated adverse events: a systematic review and metaanalysis. <em>PLoS One<\/em> 2015;<strong>10<\/strong>(4): e0122918. <\/li>","DOI":"10.1371\/journal.pone.0122918"},{"key":"10.12890\/2021_002249_ref4","doi-asserted-by":"crossref","unstructured":"<li>Brown SG. Cardiovascular aspects of anaphylaxis: implications for treatment and diagnosis. <em>Curr Opin Allergy Clin Immunol<\/em> 2005;<strong>5<\/strong>(4):359\u2013364.<\/li>","DOI":"10.1097\/01.all.0000174158.78626.35"},{"key":"10.12890\/2021_002249_ref5","doi-asserted-by":"crossref","unstructured":"<li>Fassio F, Losappio L, Antolin-Amerigo D, et al. Kounis syndrome: a concise review with focus on management. <em>Eur J Intern Med<\/em> 2016;<strong>30<\/strong>:7\u201310.<\/li>","DOI":"10.1016\/j.ejim.2015.12.004"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2249\/2548","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2249\/2549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2249\/2549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:43:19Z","timestamp":1756374199000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/2249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,8]]},"references-count":5,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.12890\/2021_002249","relation":{"has-manifestation":[{"id-type":"other","id":"1-67-2249-g2548","asserted-by":"subject"},{"id-type":"other","id":"1-67-2249-g2549","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-67","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2021,2,8]]},"article-number":"21"}}