{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:03:34Z","timestamp":1756425814404,"version":"3.44.0"},"reference-count":5,"publisher":"SMC Media","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Temozolomide is an alkylating agent, indicated in the treatment of refractory anaplastic astrocytoma and newly diagnosed glioblastoma. We describe a case of Salmonella typhimurium bacteraemia associated with septic arthritis in the setting of concurrent temozolomide use. Case: A 67-year-old woman presented with acute onset of bilateral knee pain and swelling. She had a medical history of glioblastoma multiforme treated with temozolomide. Synovial fluid analysis and blood cultures revealed S. typhimurium, confirming a diagnosis of S. typhimurium bacteraemia associated with septic arthritis. Conclusion: We conclude that chemotherapy with temozolomide and corticosteroid use will increase an individual\u2019s susceptibility to a wide variety of opportunistic infections akin to HIV-associated acquired immunodeficiency syndrome (AIDS). Furthermore, we hypothesize a possible benefit of monitoring CD4 levels and prophylaxis against opportunistic infections (based on the CD4 levels) in individuals receiving temozolomide-based chemotherapy, similar to HIV-AIDS.<\/jats:p>","DOI":"10.12890\/2021_002276","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:52:37Z","timestamp":1621936357000},"source":"Crossref","is-referenced-by-count":1,"title":["Should CD4 Levels be Monitored in a Patient on Temozolomide?"],"prefix":"10.12890","volume":"8","author":[{"given":"Sriram","family":"Gonakoti","sequence":"additional","affiliation":[{"name":"John H Stroger Jr Hospital of Cook County, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Parra-Rodriguez","sequence":"additional","affiliation":[{"name":"John H Stroger Jr Hospital of Cook County, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"key":"10.12890\/2021_002276_ref1","doi-asserted-by":"crossref","unstructured":"<li>Su YB, Sohn S, Krown SE, Livingston PO, Wolchok JD, Quinn C, et al. Selective CD4+ lymphopenia in melanoma patients treated with temozolomide: a toxicity with therapeutic implications. <em>J Clin Oncol<\/em> 2004;<strong>22<\/strong>(4):610\u2013616 [erratum in J Clin Oncol 2004;22(10):2038].<\/li>","DOI":"10.1200\/JCO.2004.07.060"},{"key":"10.12890\/2021_002276_ref2","unstructured":"<li>Stepanovic A, Nikitovic M. Severe hematologic temozolomide-related toxicity and life-threatening infections. <em>J BUON<\/em> 2018;<strong>23<\/strong>(1):7\u201313. <\/li>"},{"key":"10.12890\/2021_002276_ref3","unstructured":"<li>Kizilarslanoglu MC, Aksoy S, Yildirim NO, Ararat E, Sahin I, Altundag K. Temozolomide-related infections: review of the literature. <em>J BUON<\/em> 2011;<strong>16<\/strong>(3):547\u2013550. <\/li>"},{"key":"10.12890\/2021_002276_ref4","doi-asserted-by":"crossref","unstructured":"<li>Georgescu G, Isola IM, Youssef S, Adachi J, Rolston K. Disseminated salmonellosis in a patient treated with temozolomide. <em>J Infect<\/em> 2008;<strong>57<\/strong>(5):414\u2013415. <\/li>","DOI":"10.1016\/j.jinf.2008.06.021"},{"key":"10.12890\/2021_002276_ref5","unstructured":"<li>National Comprehensive Cancer Network (NCCN). Clinical Practice Guidelines in Oncology. Prevention and treatment of cancer-related infections. Version 2.2020. http:\/\/www.nccn.org <\/li>"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2276\/2594","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2276\/2595","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2276\/2595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:11:58Z","timestamp":1756372318000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/2276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,11]]},"references-count":5,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.12890\/2021_002276","relation":{"has-manifestation":[{"id-type":"other","id":"1-69-2276-g2594","asserted-by":"subject"},{"id-type":"other","id":"1-69-2276-g2595","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-69","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2021,3,11]]},"article-number":"20"}}