{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:10:18Z","timestamp":1756375818845,"version":"3.44.0"},"reference-count":5,"publisher":"SMC Media","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Granulomatosis with polyangiitis (Wegener\u2019s granulomatosis) is a systemic vasculitis that primarily affects small and medium vessels. Its manifestations are usually confined to the upper airway, lower airway and kidney. It can also affect other organs and systems, although this is unusual. We describe the case of a 67-year-old woman who presented with a tension pneumothorax due to rupture of a pulmonary cavity. This pulmonary cavity proved to be secondary to systemic disease which also caused a tumour in her kidney. Biopsy showed non-necrotizing granulomatosis, and even though antineutrophil cytoplasmic antibodies (ANCA) were negative, the diagnosis of granulomatosis with polyangiitis was made.<\/jats:p>","DOI":"10.12890\/2021_002304","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:52:37Z","timestamp":1621936357000},"source":"Crossref","is-referenced-by-count":0,"title":["Tension Pneumothorax as Initial Manifestation of Granulomatosis with Polyangiitis (GPA)"],"prefix":"10.12890","volume":"8","author":[{"given":"R\u00faben","family":"Reis","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Centro Hospitalar Barreiro-Montijo, Barreiro, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anneke","family":"Joosten","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Centro Hospitalar Barreiro-Montijo, Barreiro, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francelino","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Centro Hospitalar Barreiro-Montijo, Barreiro, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magda","family":"Silva","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Centro Hospitalar Barreiro-Montijo, Barreiro, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catarina","family":"Parente","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Centro Hospitalar Barreiro-Montijo, Barreiro, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00eas","family":"Maia","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Centro Hospitalar Barreiro-Montijo, Barreiro, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2021,2,11]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"<li>Grygiel-G\u00f3rniak B, Limphaibool N, Perkowska K, Puszczewicz M. Clinical manifestations of granulomatosis with polyangiitis: key considerations and major features. <em>Postgrad Med<\/em> 2018;<strong>130<\/strong>(7):581\u2013596. <\/li>","key":"10.12890\/2021_002304_ref1","DOI":"10.1080\/00325481.2018.1503920"},{"doi-asserted-by":"crossref","unstructured":"<li>Belhassen-Garcia M, Velasco-Tirado V, Alvela-Suar\u00e9z L, Carpio-P\u00e9rez A, Lled\u00edas JP, Novoa N, et al. Spontaneous pneumothorax in Wegener\u2019s granulomatosis: case report and literature review. <em>Semin Arthritis Rheum<\/em> 2011;<strong>41<\/strong>(3):455\u2013460. <\/li>","key":"10.12890\/2021_002304_ref2","DOI":"10.1016\/j.semarthrit.2011.05.001"},{"doi-asserted-by":"crossref","unstructured":"<li>Kumar S, Pawani N, Bawankule S, Diwan S, Honmode A, Jain S. Wegener's granulomatosis presenting as spontaneous pneumothorax in young adult. <em>J Assoc Chest Physicians<\/em> 2014;<strong>2<\/strong>(2):75. <\/li>","key":"10.12890\/2021_002304_ref3","DOI":"10.4103\/2320-8775.135117"},{"doi-asserted-by":"crossref","unstructured":"<li>Kashiwagi T, Hayama N, Fujita E, Hara K, Mii A, Masuda Y, et al. A case of (double) ANCA-negative granulomatosis with polyangiitis (Wegener\u2019s). <em>CEN Case Rep<\/em> 2012;<strong>1<\/strong>(2):104\u2013111. <\/li>","key":"10.12890\/2021_002304_ref4","DOI":"10.1007\/s13730-012-0023-4"},{"doi-asserted-by":"crossref","unstructured":"<li>Lutalo PMK, D\u2019Cruz DP. Diagnosis and classification of granulomatosis with polyangiitis (aka Wegener\u2019s granulomatosis). <em>J Autoimmun<\/em> 2014;<strong>48\u201349<\/strong>:94\u201398. <\/li>","key":"10.12890\/2021_002304_ref5","DOI":"10.1016\/j.jaut.2014.01.028"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2304\/2554","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2304\/2555","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2304\/2555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:43:13Z","timestamp":1756374193000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/2304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,11]]},"references-count":5,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.12890\/2021_002304","relation":{"has-manifestation":[{"id-type":"other","id":"1-67-2304-g2554","asserted-by":"subject"},{"id-type":"other","id":"1-67-2304-g2555","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-67","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2021,2,11]]},"article-number":"18"}}