{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T16:35:25Z","timestamp":1788107725364,"version":"build-2803163510"},"reference-count":7,"publisher":"SMC Media","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Copper, as a salt, is toxic and has the potential to harm multiple organs. Copper intoxication causes intravascular haemolysis followed by liver and kidney failure that can be fatal. We present a case of chronic copper sulfate poisoning in a 66-year-old man with dysphagia to solids and liquids, anaemia, acute kidney injury, liver cytolysis and hypocalcaemia. The patient improved with supportive care, but chronic kidney disease was established. Anamnesis was crucial for the diagnosis, given the non-specific signs and symptoms. The history of chronic exposure to pest treatment with a blue dust cloud made us suspect copper sulfate poisoning.<\/jats:p>","DOI":"10.12890\/2021_002309","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:52:37Z","timestamp":1621936357000},"source":"Crossref","is-referenced-by-count":2,"title":["Chronic Copper Sulfate Poisoning"],"prefix":"10.12890","volume":"8","author":[{"given":"Ana Paula","family":"Perestrelo","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio Cova da Beira, Alameda P\u00earo da Covilh\u00e3, Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5011-0940","authenticated-orcid":false,"given":"Gon\u00e7alo Filipe Lopes","family":"Miranda","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio Cova da Beira"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria In\u00eas","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio Cova da Beira, Alameda P\u00earo da Covilh\u00e3, Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Belino","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio Cova da Beira, Alameda P\u00earo da Covilh\u00e3, Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Ballesteros","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio Cova da Beira, Alameda P\u00earo da Covilh\u00e3, Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10397","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"key":"10.12890\/2021_002309_ref1","doi-asserted-by":"crossref","unstructured":"<li>Arena M, Auteri D, Barmaz S, Bellisai G, Brancato A, Brocca D, et al. Peer review of the pesticide risk assessment of the active substance copper compounds copper(I), copper(II) variants namely copper hydroxide, copper oxychloride, tribasic copper sulfate, copper(I) oxide, Bordeaux mixture. <em>EFSA J<\/em> 2018;<strong>16<\/strong>(1):e05152.<\/li>","DOI":"10.2903\/j.efsa.2018.5152"},{"key":"10.12890\/2021_002309_ref2","doi-asserted-by":"crossref","unstructured":"<li>Gunay N, Yildirim C, Karcioglu O, Gunay NE, Yilmaz M, Usalan C, et al. A series of patients in the emergency department diagnosed with copper poisoning: recognition equals treatment. <em>Tohoku J Exp Med<\/em> 2006;<strong>209<\/strong>(3):243\u2013248.<\/li>","DOI":"10.1620\/tjem.209.243"},{"key":"10.12890\/2021_002309_ref3","doi-asserted-by":"crossref","unstructured":"<li>Gamakaranage CS, Rodrigo C, Weerasinghe S, Gnanathasan A, Puvanaraj V, Fernando H. Complications and management of acute copper sulphate poisoning; a case discussion. <em>J Occup Med Toxicol<\/em> 2011;<strong>6<\/strong>(1):34.<\/li>","DOI":"10.1186\/1745-6673-6-34"},{"key":"10.12890\/2021_002309_ref4","unstructured":"<li>Yang CC, Wu ML, Deng JF. Prolonged hemolysis and methemoglobinemia following organic copper fungicide ingestion. <em>Vet Hum Toxicol<\/em> 2004;<strong>46<\/strong>(6):321\u2013323.<\/li>"},{"key":"10.12890\/2021_002309_ref5","doi-asserted-by":"crossref","unstructured":"<li>Faure A, Mathon L, Poupelin JC, Allaouchiche B, Chassard, D. Acute cupric sulfate intoxication: pathophysiology and therapy about a case report. <em>Ann Fr Anesth Reanim<\/em> 2003;<strong>22<\/strong>(6):557\u2013559.<\/li>","DOI":"10.1016\/S0750-7658(03)00132-1"},{"key":"10.12890\/2021_002309_ref6","doi-asserted-by":"crossref","unstructured":"<li>Franchitto N, Gandia-Mailly P, Georges B, Galinier A, Telmon N, Ducass\u00e9 JL, et al. Acute copper sulphate poisoning: a case report and literature review. <em>Resuscitation<\/em> 2008;<strong>78<\/strong>(1):92\u201396.<\/li>","DOI":"10.1016\/j.resuscitation.2008.02.017"},{"key":"10.12890\/2021_002309_ref7","doi-asserted-by":"crossref","unstructured":"<li>Naha K, Saravu K, Shastry BA. Blue vitriol poisoning: a 10-year experience in a tertiary care hospital. <em>Clin Toxicol<\/em> 2012;<strong>50<\/strong>(3):197\u2013201.<\/li>","DOI":"10.3109\/15563650.2012.660572"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2309\/2562","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2309\/2563","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2309\/2563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:42:59Z","timestamp":1756374179000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/2309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,17]]},"references-count":7,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.12890\/2021_002309","relation":{"has-manifestation":[{"id-type":"other","id":"1-67-2309-g2562","asserted-by":"subject"},{"id-type":"other","id":"1-67-2309-g2563","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-67","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,17]]},"article-number":"14"}}