{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:40:04Z","timestamp":1756374004681,"version":"3.44.0"},"reference-count":14,"publisher":"SMC Media","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Case Description: TA 28-year old woman receiving thiopurine treatment for Crohn\u2019s disease presented with a systemic primo cytomegalovirus (CMV) infection affecting the gut (colitis), liver (hepatitis), lungs (pneumonitis) and eyes (retinitis). Secondary to this systemic infection, she developed splenomegaly, pancytopenia and lymphadenopathy. Anti-viral treatment resulted in complete resolution of clinical, biochemical and radiological abnormalities within 6 weeks.\u00a0 Conclusion: Early recognition is crucial since CMV infection in a patient receiving thiopurine treatment may result in serious complications.<\/jats:p>","DOI":"10.12890\/2021_002350","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:52:37Z","timestamp":1621936357000},"source":"Crossref","is-referenced-by-count":3,"title":["Severe Complication of Thiopurine Treatment in a Young Woman with Crohn\u2019s Disease"],"prefix":"10.12890","volume":"8","author":[{"given":"Michiel PJ","family":"Voet","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Catharina Ziekenhuis, Eindhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TGA","family":"Calon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Catharina Ziekenhuis, Eindhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MMC","family":"Hendriks","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Catharina Ziekenhuis, Eindhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RM","family":"Schreuder","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Catharina Ziekenhuis, Eindhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"10.12890\/2021_002350_ref1","doi-asserted-by":"crossref","unstructured":"<li>Cannon MJ, Schmid DS, Hyde TB. Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection. <em>Rev Med Virol<\/em> 2010;<strong>20<\/strong>:202\u2013213.<\/li>","DOI":"10.1002\/rmv.655"},{"key":"10.12890\/2021_002350_ref2","doi-asserted-by":"crossref","unstructured":"<li>Gomoll\u00f3n F, Dignass A, Annese V, Tilg H, Van Assche G, Lindsay JO, et al. 3rd European evidence-based consensus on the diagnosis and management of Crohn\u2019s disease 2016: Part 1: Diagnosis and medical management. <em>J Crohn\u2019s Colitis<\/em> 2017;<strong>11<\/strong>:3\u201325.<\/li>","DOI":"10.1093\/ecco-jcc\/jjw168"},{"key":"10.12890\/2021_002350_ref3","unstructured":"<li>Richtlijn diagnostiek en behandeling van inflammatoire darmziekten bij volwassenen. Haarlem: The Netherlands: Nederlandse Vereniging van Maag-Darm-Leverartsen; 2008.<\/li>"},{"key":"10.12890\/2021_002350_ref4","doi-asserted-by":"crossref","unstructured":"<li>Papadakis KA, Tung JK, Binder SW, Kam LY, Abreu MT, Targan SR, et al. Outcome of cytomegalovirus infections in patients with inflammatory bowel disease. <em>Am J Gastroenterol<\/em> 2001;<strong>96<\/strong>:2137\u20132142.<\/li>","DOI":"10.1111\/j.1572-0241.2001.03949.x"},{"key":"10.12890\/2021_002350_ref5","doi-asserted-by":"crossref","unstructured":"<li>Kandiel A, Lashner B. Cytomegalovirus colitis complicating inflammatory bowel disease. <em>Am J Gastroenterol<\/em> 2006;<strong>101<\/strong>:2857\u20132865.<\/li>","DOI":"10.1111\/j.1572-0241.2006.00869.x"},{"key":"10.12890\/2021_002350_ref6","doi-asserted-by":"crossref","unstructured":"<li>Rafailidis PI, Mourtzoukou EG, Varbobitis IC, Falagas ME. Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review. <em>Virol J<\/em> 2008;<strong>5<\/strong>:1\u20137.<\/li>","DOI":"10.1186\/1743-422X-5-47"},{"key":"10.12890\/2021_002350_ref7","doi-asserted-by":"crossref","unstructured":"<li>Shukla T, Singh S, Tandon P, McCurdy JD. 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Cytomegalovirus disease, haemophagocytic syndrome, immunosuppression in patients with IBD: \u2018A cocktail best avoided, not stirred\u2019. <em>J Crohn\u2019s Colitis<\/em> 2011;<strong>5<\/strong>:469\u2013472.<\/li>","DOI":"10.1016\/j.crohns.2011.04.010"},{"key":"10.12890\/2021_002350_ref14","doi-asserted-by":"crossref","unstructured":"<li>Abreu C, Sarmento A, Magro F. 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