{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:03:12Z","timestamp":1756425792640,"version":"3.44.0"},"reference-count":6,"publisher":"SMC Media","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>We report the case of a 76-year-old man presenting with reactive haemophagocytic lymphohistiocytosis (rHLH) in the setting of disseminated prostate cancer. This often fatal syndrome must be diagnosed early in order to maximize survival. Treatment should be initiated whenever the clinical diagnosis is suspected, even if the HLH-2004 criteria are not met. The HScore is a useful diagnostic tool for rHLH. In case of neurological symptoms, an extensive assessment must be performed. The goal of this case report is to raise awareness of this rare syndrome among oncologists.<\/jats:p>","DOI":"10.12890\/2021_002425","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T10:11:37Z","timestamp":1621937497000},"source":"Crossref","is-referenced-by-count":1,"title":["Prostate Cancer and Reactive Haemophagocytic Lymphohistiocytosis"],"prefix":"10.12890","volume":"8","author":[{"given":"Laura","family":"Dumont","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"Salaroli","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lissandra","family":"Dal Lago","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Gil","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Pepersack","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"key":"10.12890\/2021_002425_ref1","doi-asserted-by":"crossref","unstructured":"<li>Koizumi K, Haseyama Y, Machino R, Sato Y, Sawada K, Koike T. The hemophagocytic syndrome in prostate cancer revealed by disseminated carcinomatosis of the bone marrow.<em> J Urol <\/em>2002;<strong>168<\/strong>(3):1101\u20131102. <\/li>","DOI":"10.1016\/S0022-5347(05)64588-0"},{"key":"10.12890\/2021_002425_ref2","doi-asserted-by":"crossref","unstructured":"<li>Declerck L, Adenis C, Amela E, Caty A, Adenis A, Penel N. Prostate cancer related haemophagocytic syndrome: successful treatment with chemotherapy.<em> Acta Oncol<\/em> 2012;<strong>51<\/strong>(2):268\u2013269. <\/li>","DOI":"10.3109\/0284186X.2011.608377"},{"key":"10.12890\/2021_002425_ref3","doi-asserted-by":"crossref","unstructured":"<li>Bergsten E, Horne A, Aric\u00f3 M, Astigarraga I, Egeler RM, Filipovich AH, et al. Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study. <em>Blood<\/em> 2017;<strong>130<\/strong>(25):2728\u20132738. <\/li>","DOI":"10.1182\/blood-2017-06-788349"},{"key":"10.12890\/2021_002425_ref4","doi-asserted-by":"crossref","unstructured":"<li>Fardet L, Galicier L, Lambotte O, Marzac C, Aumont C, Chahwan D, et al. Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome: score for reactive hemophagocytic syndrome. <em>Arthritis Rheumatol<\/em> 2014;<strong>66<\/strong>(9):2613\u20132620. <\/li>","DOI":"10.1002\/art.38690"},{"key":"10.12890\/2021_002425_ref5","doi-asserted-by":"crossref","unstructured":"<li>Vaidya HC, Wolf BA, Garrett N, Catalona WJ, Clayman RV, Nahm MH. Extremely high values of prostate-specific antigen in patients with adenocarcinoma of the prostate; demonstration of the \u2018hook effect\u2019. <em>Clin Chem<\/em> 1988;<strong>34<\/strong>(10):2175\u20132177. <\/li>","DOI":"10.1093\/clinchem\/34.10.2175"},{"key":"10.12890\/2021_002425_ref6","doi-asserted-by":"crossref","unstructured":"<li>Novotny F, Simonetta F, Samii K, Chalandon Y, Serratrice J. Syndrome h\u00e9mophagocytaire r\u00e9actionnel. <em>Rev Med Suisse<\/em> 2017;<strong>13<\/strong>:1797\u20131803. Available from: https:\/\/www.revmed.ch\/RMS\/2017\/RMS-N-579\/Syndrome-hemophagocytaire-reactionnel#B28.<\/li>","DOI":"10.53738\/REVMED.2017.13.579.1797"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2425\/2626","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2425\/2627","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2425\/2627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:27:15Z","timestamp":1756369635000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/2425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":6,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.12890\/2021_002425","relation":{"has-manifestation":[{"id-type":"other","id":"1-70-2425-g2626","asserted-by":"subject"},{"id-type":"other","id":"1-70-2425-g2627","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-70","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2021,4,1]]},"article-number":"23"}}