{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:55:00Z","timestamp":1771653300589,"version":"3.50.1"},"reference-count":8,"publisher":"SMC Media","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Hypoparathyroidism is a rare endocrine disorder and its main cause is cervical surgery such as thyroidectomy. The incidence of hypoparathyroidism after total thyroidectomy varies, and is reported to be between 0.3 and 6.3%. In terms of brain imaging, hypoparathyroidism can cause calcification mainly of the basal ganglia, with other areas rarely affected. Concerning extracerebral calcification, few studies have investigated the prevalence of visceral calcifications.\u00a0 We describe a case of a woman with secondary hypocalcaemia who presented with a transient ischaemic attack (TIA) and the investigation revealed an extensive calcinosis of the brain and the vascular structures responsible for the event.<\/jats:p>","DOI":"10.12890\/2021_002489","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T04:42:16Z","timestamp":1622090536000},"source":"Crossref","is-referenced-by-count":2,"title":["Diffuse Calcinosis from Total Thyroidectomy and Secondary Hypocalcaemia"],"prefix":"10.12890","volume":"8","author":[{"given":"Filipa","family":"Leal","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do T\u00e2mega e Sousa, Penafiel, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00eds","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do T\u00e2mega e Sousa, Penafiel, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa Martins Mendes","family":"Teresa Martins Mendes","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do T\u00e2mega e Sousa, Penafiel, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Silva Rocha","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do T\u00e2mega e Sousa, Penafiel, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinis","family":"Sarmento","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do T\u00e2mega e Sousa, Penafiel, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Pombo","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do T\u00e2mega e Sousa, Penafiel, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara","family":"Silva","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do T\u00e2mega e Sousa, Penafiel, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"key":"10.12890\/2021_002489_ref1","doi-asserted-by":"crossref","unstructured":"<li>Abate EG, Clarke BL. Review of hypoparathyroidism. <em>Front Endocrinol<\/em> 2017;<strong>7<\/strong>:172.<\/li>","DOI":"10.3389\/fendo.2016.00172"},{"key":"10.12890\/2021_002489_ref2","doi-asserted-by":"crossref","unstructured":"<li>Lorente-Poch L, Rif\u00e0-Terricabras S, Sancho JJ, Torselli-Valladares D, Gonz\u00e1lez-Ortiz S, Sitges-Serra A. Prevalence of basal ganglia and carotid artery calcifications in patients with permanent hypoparathyroidism after total thyroidectomy. <em>Endocr Connect<\/em> 2020;<strong>9<\/strong>(10):955\u2013962.<\/li>","DOI":"10.1530\/EC-20-0387"},{"key":"10.12890\/2021_002489_ref3","doi-asserted-by":"crossref","unstructured":"<li>Cooper MS, Gittoes NJ. Diagnosis and management of hypocalcaemia. <em>BMJ<\/em> 2008;<strong>336<\/strong>(7656):1298\u20131302.<\/li>","DOI":"10.1136\/bmj.39582.589433.BE"},{"key":"10.12890\/2021_002489_ref4","doi-asserted-by":"crossref","unstructured":"<li>Mitchell DM, Regan S, Cooley MR, Lauter KB, Vrla MC, Becker CB, et al. Long-term follow-up of patients with hypoparathyroidism. <em>J Clin Endocrinol Metab<\/em> 2012;<strong>97<\/strong>(12):4507\u20134514.<\/li>","DOI":"10.1210\/jc.2012-1808"},{"key":"10.12890\/2021_002489_ref5","doi-asserted-by":"crossref","unstructured":"<li>Zisimopoulou V, Siatouni A, Tsoukalos G, Tavernarakis A, Gatzonis S. Extensive bilateral intracranial calcifications: a case of iatrogenic hypoparathyroidism. <em>Case Rep Med<\/em> 2013;<strong>2013<\/strong>:932184.<\/li>","DOI":"10.1155\/2013\/932184"},{"key":"10.12890\/2021_002489_ref6","doi-asserted-by":"crossref","unstructured":"<li>Agarwal R, Lahiri D, Biswas A, Mukhopadhyay J, Maity P, Roy MK. A rare cause of seizures, parkinsonian, and cerebellar signs: brain calcinosis secondary to thyroidectomy. <em>N Am J Med Sci<\/em> 2014;6(10):540\u2013542.<\/li>","DOI":"10.4103\/1947-2714.143287"},{"key":"10.12890\/2021_002489_ref7","doi-asserted-by":"crossref","unstructured":"<li>Donzuso G, Mostile G, Nicoletti A, Zappia M. Basal ganglia calcifications (Fahr's syndrome): related conditions and clinical features.<em> Neurol Sci<\/em> 2019;<strong>40<\/strong>(11):2251\u20132263.<\/li>","DOI":"10.1007\/s10072-019-03998-x"},{"key":"10.12890\/2021_002489_ref8","doi-asserted-by":"crossref","unstructured":"Lines SW, Ramadan H. Looking beyond the obvious: cerebral calcification. <em>Pract Neurol<\/em> 2013;<strong>13<\/strong>(6):386\u2013387.<\/li>","DOI":"10.1136\/practneurol-2013-000591"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2489\/2700","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2489\/2701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2489\/2701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T13:49:50Z","timestamp":1756129790000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/2489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,27]]},"references-count":8,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.12890\/2021_002489","relation":{"has-manifestation":[{"id-type":"other","id":"1-71-2489-g2700","asserted-by":"subject"},{"id-type":"other","id":"1-71-2489-g2701","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-71","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,27]]},"article-number":"6"}}