{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:40:05Z","timestamp":1756370405224,"version":"3.44.0"},"reference-count":5,"publisher":"SMC Media","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Spontaneous coronary artery dissection (SCAD) is increasingly recognized as an important cause of acute coronary syndrome (ACS) and myocardial infarction (MI) in individuals with few or no known atherosclerotic risk factors. While systemic autoimmune inflammatory disorders are associated with precipitating SCAD, the role of infection-induced systemic inflammation in SCAD is not well defined. We present the case of a 49-year-old Caucasian woman with ST-elevation myocardial infarction (STEMI) diagnosed as SCAD from a severe systemic inflammatory response related to disseminated blastomycosis. Punch biopsy of a skin lesion and synovial fluid culture confirmed Blastomyces dermatitidis. This case suggests the possibility of systemic infection-induced inflammation as a precipitating factor in SCAD pathogenesis similar to autoimmune inflammatory disorders.<\/jats:p>","DOI":"10.12890\/2021_002511","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T10:11:37Z","timestamp":1621937497000},"source":"Crossref","is-referenced-by-count":1,"title":["Disseminated Blastomycosis Presenting with Spontaneous Coronary Artery Dissection"],"prefix":"10.12890","volume":"8","author":[{"given":"Rahul","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Mayo Clinic Alix School of Medicine, Mayo Clinic Health System, Eau Claire, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D Fearghas","family":"O'Cochlain","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Alix School of Medicine, Mayo Clinic Health System, Eau Claire, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Virata","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mayo Clinic Alix School of Medicine, Mayo Clinic Health System, Eau Claire, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurpreet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Alix School of Medicine, Mayo Clinic Health System, Eau Claire, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2021,4,23]]},"reference":[{"key":"10.12890\/2021_002511_ref1","doi-asserted-by":"crossref","unstructured":"<li>Kim ESH. Spontaneous coronary-artery dissection. <em>N Engl J Med<\/em> 2020;<strong>383<\/strong>(24):2358\u20132370.<\/li>","DOI":"10.1056\/NEJMra2001524"},{"key":"10.12890\/2021_002511_ref2","doi-asserted-by":"crossref","unstructured":"<li>Saw J, Aymong E, Sedlak T, Buller CE, Starovoytov A, Ricci D, et al. Spontaneous coronary artery dissection: association with predisposing arteriopathies and precipitating stressors and cardiovascular outcomes. <em>Circ Cardiovasc Interv<\/em> 2014;<strong>7<\/strong>(5):645\u2013655.<\/li>","DOI":"10.1161\/CIRCINTERVENTIONS.114.001760"},{"key":"10.12890\/2021_002511_ref3","doi-asserted-by":"crossref","unstructured":"<li>Shojaei F, Habibi Z, Goudarzi S, Firouzabadi FD, Montazerin SM, Najafi H, et al. COVID-19: a double threat to takotsubo cardiomyopathy and spontaneous coronary artery dissection? <em>Med Hypotheses<\/em> 2021;<strong>146<\/strong>:110410.<\/li>","DOI":"10.1016\/j.mehy.2020.110410"},{"key":"10.12890\/2021_002511_ref4","doi-asserted-by":"crossref","unstructured":"<li>Adlam D, Alfonso F, Maas A, Vrints C. European Society of Cardiology, Acute Cardiovascular Care Association, SCAD Study Group: a position paper on spontaneous coronary artery dissection. <em>Eur Heart J<\/em> 2018;<strong>39<\/strong>:3353\u20133368.<\/li>","DOI":"10.1093\/eurheartj\/ehy080"},{"key":"10.12890\/2021_002511_ref5","doi-asserted-by":"crossref","unstructured":"<li>Pitliya A, Datta S, Kalayci A, Kahe F, Sharfaei S, Jafarizade M, et al. Eosinophilic inflammation in spontaneous coronary artery dissection: a potential therapeutic target? <em>Med Hypotheses<\/em> 2018;<strong>121<\/strong>:91\u201394.<\/li>","DOI":"10.1016\/j.mehy.2018.09.039"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2511\/2656","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2511\/2657","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2511\/2657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:26:42Z","timestamp":1756369602000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/2511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,23]]},"references-count":5,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.12890\/2021_002511","relation":{"has-manifestation":[{"id-type":"other","id":"1-70-2511-g2656","asserted-by":"subject"},{"id-type":"other","id":"1-70-2511-g2657","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-70","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2021,4,23]]},"article-number":"8"}}