{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:08:11Z","timestamp":1756166891534,"version":"3.44.0"},"reference-count":5,"publisher":"SMC Media","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Erythema nodosum (EN) is an inflammatory condition of the subcutaneous fat and has been reported in patients with haematological malignancies (lymphomas) or solid tumours. Lung cancer is the most common cause of paraneoplastic syndrome. We report a case of EN occurring as a paraneoplastic disease. A 48-year-old Tunisian woman, a non-smoker with no relevant medical history, presented with painful, erythematous, firm nodules on her legs with ankle swelling. The patient did not report any other symptoms. There were no abnormalities on examination except for moderate fever. An extensive infectious and immunological investigation was negative. Antistreptolysin antibodies were undetectable. Chest radiography showed a focal opacity in the right lung and a CT scan revealed a mass in the lower right pulmonary lobe with hilar and mediastinal lymphadenopathies, a nodule in the right adrenal gland, condensation in the iliac bone and multiple bilateral nodular cerebral expansive processes. Bronchial biopsies revealed a primitive and moderately differentiated adenocarcinoma. No argument for tuberculosis or sarcoidosis was found.<\/jats:p>","DOI":"10.12890\/2021_002539","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T03:50:13Z","timestamp":1626839413000},"source":"Crossref","is-referenced-by-count":0,"title":["Erythema Nodosum Revealing Metastatic Lung Cancer"],"prefix":"10.12890","volume":"8","author":[{"given":"Anis","family":"Mzabi","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Sahloul University Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wafa","family":"Benzarti","sequence":"additional","affiliation":[{"name":"Pneumology Department, Farhat Hached University Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiem","family":"Romdhane","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Sahloul University Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wafa","family":"Baya","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Sahloul University Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana","family":"Aissa","sequence":"additional","affiliation":[{"name":"Pneumology Department, Farhat Hached University Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imen","family":"Gargouri","sequence":"additional","affiliation":[{"name":"Pneumology Department, Farhat Hached University Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chedia","family":"Laouani","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Sahloul University Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"key":"10.12890\/2021_002539_ref1","doi-asserted-by":"crossref","unstructured":"<li>Chowaniec M, Starba A, Wiland P. Erythema nodosum \u2013 review of the literature. <em>Reumatologia<\/em> 2016;<strong>54<\/strong>(2):79.<\/li>","DOI":"10.5114\/reum.2016.60217"},{"key":"10.12890\/2021_002539_ref2","doi-asserted-by":"crossref","unstructured":"<li>Perez NB, Bernad B, Narv\u00e1ez J, Valverde J. Erythema nodosum and lung cancer. <em>Joint Bone Spine<\/em> 2006;<strong>73<\/strong>(3):337.<\/li>","DOI":"10.1016\/j.jbspin.2005.10.009"},{"key":"10.12890\/2021_002539_ref3","doi-asserted-by":"crossref","unstructured":"<li>Fu Y, Chi CC. A case of lung cancer presenting with erythema nodosum. <em>Dermatol Sin<\/em> 2020;<strong>38<\/strong>(4):246.<\/li>","DOI":"10.4103\/ds.ds_22_20"},{"key":"10.12890\/2021_002539_ref4","doi-asserted-by":"crossref","unstructured":"<li>Antoine M, Moroch J, Kebir F, Georges M, Ruppert A-M, Wislez M. Classification histomol\u00e9culaire des cancers pulmonaires. <em>Rev Malad Respir Actual<\/em> 2018;<strong>10<\/strong>(3):236\u2013247.<\/li>","DOI":"10.1016\/S1877-1203(18)30016-8"},{"key":"10.12890\/2021_002539_ref5","doi-asserted-by":"crossref","unstructured":"<li>Youssef M, Kechida M, Cheikhmohamed S, Moussa A. Multiple paraneoplastic syndromes revealing non-small cell lung carcinoma. <em>Pan Afr Med J<\/em> 2014;<strong>19<\/strong>:237.<\/li>","DOI":"10.11604\/pamj.2014.19.237.4409"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2539\/2773","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2539\/2774","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2539\/2774","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T13:39:42Z","timestamp":1756129182000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/2539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,21]]},"references-count":5,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.12890\/2021_002539","relation":{"has-manifestation":[{"id-type":"other","id":"1-73-2539-g2773","asserted-by":"subject"},{"id-type":"other","id":"1-73-2539-g2774","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-73","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2021,7,21]]},"article-number":"10"}}