{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:08:18Z","timestamp":1756166898606,"version":"3.44.0"},"reference-count":5,"publisher":"SMC Media","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Objectives: There is limited experience regarding the meaning of SARS-CoV-2 antibodies after vaccination in patients with naturally acquired immunity. Methods: We describe the case of a patient who received the first dose of the mRNA-1273 SARS-CoV-2 vaccine 6 months after his recovery from moderately severe COVID-19. Results: Our patient had a positive nucleocapsid SARS-CoV-2 IgG\/IgM titre with 78.7 multiple of cut-off indicating persistent humoral immune response 6 months after infection. After vaccination, he developed prolonged systemic symptoms (fever, fatigue, nausea, diarrhoea and myalgia) for a duration of 6 days. Conclusion: SARS-CoV-2 nucleocapsid antibodies provide information about naturally acquired immunity. For the assessment of immune response to vaccination, measurement of the SARS-CoV-2 spike antibody titre before and after vaccination is essential. Patients with naturally acquired immunity might develop a prolonged systemic reaction to the first dose of the mRNA-1273 SARS-CoV-2 vaccine.<\/jats:p>","DOI":"10.12890\/2021_002617","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T04:42:22Z","timestamp":1622781742000},"source":"Crossref","is-referenced-by-count":0,"title":["The Meaning of SARS-CoV-2 Antibodies in a Patient with a Systemic Reaction to the mRNA-1273 SARS-CoV-2 Vaccine after Previous Natural Immunization"],"prefix":"10.12890","volume":"8","author":[{"given":"Lorraine","family":"Sazgary","sequence":"additional","affiliation":[{"name":"Medical Outpatient Clinic, University Hospital Basel, University of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Meienberg","sequence":"additional","affiliation":[{"name":"Medical Outpatient Clinic, University Hospital Basel, University of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph T","family":"Berger","sequence":"additional","affiliation":[{"name":"Medical Outpatient Clinic, University Hospital Basel, University of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Mayr","sequence":"additional","affiliation":[{"name":"Medical Outpatient Clinic, University Hospital Basel, University of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2021,6,4]]},"reference":[{"key":"10.12890\/2021_002617_ref1","doi-asserted-by":"crossref","unstructured":"<li>Masters PS. The molecular biology of coronaviruses. <em>Adv Virus Res<\/em> 2006;<strong>65<\/strong>:193\u2013292. doi:10.1016\/S0065-3527(06)66005-3<\/li>","DOI":"10.1016\/S0065-3527(06)66005-3"},{"key":"10.12890\/2021_002617_ref2","doi-asserted-by":"crossref","unstructured":"<li>Dan JM, Mateus J, Kato Y, Hastie KM, Yu ED, Faliti CE, et al. Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection. <em>Science<\/em> 2021;<strong>371<\/strong>(6529):eabf4063. <\/li>doi:10.1126\/science.abf4063<\/li>","DOI":"10.1126\/science.abf4063"},{"key":"10.12890\/2021_002617_ref3","doi-asserted-by":"crossref","unstructured":"<li>Baden LR, El Sahly HM, Essink B, Kotloff K, Frey S, Novak R, et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. <em>N Engl J Med<\/em> 2021;<strong>384<\/strong>(5):403\u2013416. doi:10.1056\/nejmoa2035389<\/li>","DOI":"10.1056\/NEJMoa2035389"},{"key":"10.12890\/2021_002617_ref4","doi-asserted-by":"crossref","unstructured":"<li>Krammer F, Srivastava K, Alshammary H, Amoako AA, Awawda MH, Beach KF, et al. Antibody responses in seropositive persons after a single dose of SARS-CoV-2 mRNA vaccine. <em>N Engl J Med<\/em> 2021;<strong>384<\/strong>(14):1372\u20131374. doi:10.1056\/NEJMc2101667<\/li>","DOI":"10.1056\/NEJMc2101667"},{"key":"10.12890\/2021_002617_ref5","doi-asserted-by":"crossref","unstructured":"<li>Saadat S, Rikhtegaran Tehrani Z, Logue J, Newman M, Frieman MB, Harris AD, et al. Binding and neutralization antibody titers after a single vaccine dose in health care workers previously infected with SARS-CoV-2. <em>JAMA<\/em> 2021;<strong>325<\/strong>(14):1467\u20131469. doi:10.1001\/jama.2021.3341<\/li>","DOI":"10.1001\/jama.2021.3341"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2617\/2710","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2617\/2711","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2617\/2711","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T13:45:43Z","timestamp":1756129543000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/2617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,4]]},"references-count":5,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.12890\/2021_002617","relation":{"has-manifestation":[{"id-type":"other","id":"1-72-2617-g2710","asserted-by":"subject"},{"id-type":"other","id":"1-72-2617-g2711","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-72","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2021,6,4]]},"article-number":"22"}}