{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:14:07Z","timestamp":1784783647748,"version":"3.55.0"},"reference-count":5,"publisher":"SMC Media","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Dermal fillers are applied using a minimally invasive technique with a good safety profile. However, they can have side effects. We present the case of a patient who, 2 months after undergoing polycaprolactone (Ellans\u00e9\u00ae) injections, developed nodular facial and nodal lesions that were compatible with sarcoidosis on histology. This complication has not been previously described for polycaprolactone and could be the expression of an autoimmune syndrome induced by adjuvants.<\/jats:p>","DOI":"10.12890\/2021_002652","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T03:25:28Z","timestamp":1623209128000},"source":"Crossref","is-referenced-by-count":4,"title":["Cutaneous and Ganglion Sarcoidosis Induced by Polycaprolactone Facial Filler: A New Expression of ASIA Syndrome?"],"prefix":"10.12890","volume":"8","author":[{"given":"Juan","family":"Ortiz-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"UGC de Dermatolog\u00eda, Hospital Universitario Virgen del Roc\u00edo, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Antonio","family":"Lebron-Martin","sequence":"additional","affiliation":[{"name":"UGC de Dermatolog\u00eda, Hospital Universitario Virgen del Roc\u00edo, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Rodriguez Fernandez-Freire","sequence":"additional","affiliation":[{"name":"UGC de Dermatolog\u00eda, Hospital Universitario Virgen del Roc\u00edo, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Zulueta-Dorado","sequence":"additional","affiliation":[{"name":"UGC de Anatom\u00eda Patol\u00f3gica, Hospital Universitario Virgen del Roc\u00edo, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Salvador","family":"Garcia-Morillo","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Raras y Autoinmunes del Adulto, UGC Medicina Integral, Hospital Universitario Virgen del Roc\u00edo, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10397","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"10.12890\/2021_002652_ref1","doi-asserted-by":"crossref","unstructured":"<li>SWanat KA, Rosenbach M. Cutaneous sarcoidosis. <em>Clin Chest Med<\/em> 2015;<strong>36<\/strong>(4):685\u2013702. Available from: http:\/\/dx.doi.org\/10.1016\/j.ccm.2015.08.010<\/li>","DOI":"10.1016\/j.ccm.2015.08.010"},{"key":"10.12890\/2021_002652_ref2","doi-asserted-by":"crossref","unstructured":"<li>Levy L, Emer J. Complications of minimally invasive cosmetic procedures: prevention and management.<em> J Cutan Aesthet Surg<\/em> 2012;<strong>5<\/strong>(2):121\u2013132. <\/li>","DOI":"10.4103\/0974-2077.99451"},{"key":"10.12890\/2021_002652_ref3","doi-asserted-by":"crossref","unstructured":"<li>Lin SL, Christen MO. Polycaprolactone-based dermal filler complications: a retrospective study of 1111 treatments. <em>J Cosmet Dermatol<\/em> 2020;<strong>19<\/strong>(8):1907\u20131914. <\/li>","DOI":"10.1111\/jocd.13518"},{"key":"10.12890\/2021_002652_ref4","doi-asserted-by":"crossref","unstructured":"<li>Sommerfeld S, Cherry C, Schwab R, Chung L, Maestas DJ, Laffont P, et al. Interleukin-36?\u2013producing macrophages drive IL-17\u2013mediated fibrosis. <em>Sci Immunol<\/em> 2019;<strong>11<\/strong>(4):eaax4783. <\/li>","DOI":"10.1126\/sciimmunol.aax4783"},{"key":"10.12890\/2021_002652_ref5","doi-asserted-by":"crossref","unstructured":"<li>Alijotas-Reig J. Human adjuvant-related syndrome or autoimmune\/inflammatory syndrome induced by adjuvants. Where have we come from? Where are we going? A proposal for new diagnostic criteria.<em>Lupus<\/em> 2015;<strong>24<\/strong>(10):1012\u20131018. <\/li>","DOI":"10.1177\/0961203315579092"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2652\/2716","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2652\/2717","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2652\/2717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T13:45:36Z","timestamp":1756129536000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/2652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,9]]},"references-count":5,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.12890\/2021_002652","relation":{"has-manifestation":[{"id-type":"other","id":"1-72-2652-g2716","asserted-by":"subject"},{"id-type":"other","id":"1-72-2652-g2717","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-72","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,9]]},"article-number":"19"}}