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Here, we present a case report of a 57-year-old man who developed MCV with renal involvement after 3 years of HCV eradication with interferon therapy.<\/jats:p>","DOI":"10.12890\/2021_002808","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T02:49:02Z","timestamp":1630378142000},"source":"Crossref","is-referenced-by-count":0,"title":["Mixed Cryoglobulinaemia Vasculitis after Persistent Hepatitis C Virus Eradication"],"prefix":"10.12890","volume":"8","author":[{"given":"Margarida","family":"Gaud\u00eancio","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Distrital da Figueira da Foz, EPE, Figueira da Foz, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui Nogueira","family":"Rui Nogueira","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuno Afonso Oliveira","family":"Nuno Afonso Oliveira","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal; Faculty of Medicine, University of Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"key":"10.12890\/2021_002808_ref1","doi-asserted-by":"crossref","unstructured":"<li>Roccatello D, Saadoun D, Ramos-Casals M, Tzioufas AG, Fervenza FC, Cacoub P, et al. Cryoglobulinaemia. <em>Nat Rev Dis Primers<\/em> 2018;<strong>4<\/strong>(1):11.<\/li>","DOI":"10.1038\/s41572-018-0009-4"},{"key":"10.12890\/2021_002808_ref2","doi-asserted-by":"crossref","unstructured":"<li>Lauer G, Walker BD. Hepatitis C virus infection. <em>N Engl J Med<\/em> 2001;<strong>345<\/strong>(1):41\u201352.<\/li>","DOI":"10.1056\/NEJM200107053450107"},{"key":"10.12890\/2021_002808_ref3","doi-asserted-by":"crossref","unstructured":"<li>Pol S, Parlati L, Jadoul M. Hepatitis C virus and the kidney. <em>Nat Rev Nephrol<\/em> 2019;<strong>15<\/strong>:73\u201386. <\/li>","DOI":"10.1038\/s41581-018-0081-8"},{"key":"10.12890\/2021_002808_ref4","doi-asserted-by":"crossref","unstructured":"<li>Dammaco F, Sansonno D. Therapy for hepatitis C virus-related cryoglobulinemic vasculitis. <em>N Engl J Med<\/em> 2013;<strong>369<\/strong>:1035\u20131045. <\/li>","DOI":"10.1056\/NEJMra1208642"},{"key":"10.12890\/2021_002808_ref5","doi-asserted-by":"crossref","unstructured":"<li>Boonyapisit K, Katiriji B. Severe exacerbation of hepatitis C-associated vasculitic neuropathy following treatment with interferon alpha: a case report and literature review. <em>Muscle Nerve<\/em> 2002;<strong>25<\/strong>(6):909\u2013913.<\/li>","DOI":"10.1002\/mus.10118"},{"key":"10.12890\/2021_002808_ref6","doi-asserted-by":"crossref","unstructured":"<li>Beauthien W, Mellinghoff H-U, von Kempis J. Vasculitic complications of interferon-alpha treatment for chronic hepatitis C infection: case report and review of literature. <em>Clin Rheumatol<\/em> 2005;<strong>24<\/strong>(5):507\u2013515.<\/li>","DOI":"10.1007\/s10067-005-1093-x"},{"key":"10.12890\/2021_002808_ref7","doi-asserted-by":"crossref","unstructured":"<li>Kartha V, Franco L, Coventry S, McLeish K, Caster DJ, Schadt CR. Hepatitis C mixed cryoglobulinemia with undetectable viral load: a case series. <em>JAAD Case Rep<\/em> 2018;<strong>4<\/strong>:684\u2013687. <\/li>","DOI":"10.1016\/j.jdcr.2018.04.004"},{"key":"10.12890\/2021_002808_ref8","doi-asserted-by":"crossref","unstructured":"<li>Quartuccio L, De Marchi G, Fabris M, De Vita S. Development of type II cryoglobulinaemic syndrome after effective and persistent hepatitis C virus eradication. <em>Rheumatology<\/em> 2007;<strong>46<\/strong>(2):367\u2013368.<\/li>","DOI":"10.1093\/rheumatology\/kel389"},{"key":"10.12890\/2021_002808_ref9","unstructured":"<li>Silva RF, Malvar B, Santos R, Pessegueiro P, Aniceto J, Ramalho V, et al. New onset of mixed cryoglobulinemia vasculitis after persistent hepatitis C virus eradication. <em>Port J Nephrol Hypert<\/em> 2013;<strong>27<\/strong>(4):289\u2013294. <\/li>"},{"key":"10.12890\/2021_002808_ref10","doi-asserted-by":"crossref","unstructured":"<li>De Re V, Sansonno D, Simula MP, Caggiari L, Gasparotto D, Fabris M, et al. HCV-NS3 and IgG-Fc crossreative IgM in patients with type II mixed cryoglobulinemia and B-cell clonal proliferation. <em>Leukemia<\/em> 2006;<strong>20<\/strong>(6):1145\u20131154.<\/li>","DOI":"10.1038\/sj.leu.2404201"},{"key":"10.12890\/2021_002808_ref11","doi-asserted-by":"crossref","unstructured":"<li>Rosa D, Saletti G, De Gregorio E, Zorat F, Comar C, D'Oro U, et al. Activation of naive B lymphocytes via CD81, a pathogenic mechanism for hepatitis C virus associated B lymphocyte disorders. <em>Proc Natl Acad Sci USA<\/em> 2005;<strong>102<\/strong>(51):18544\u201318549.<\/li>","DOI":"10.1073\/pnas.0509402102"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2808\/2815","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2808\/2816","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2808\/2816","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T13:33:35Z","timestamp":1756128815000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/2808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,31]]},"references-count":11,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.12890\/2021_002808","relation":{"has-manifestation":[{"id-type":"other","id":"1-74-2808-g2815","asserted-by":"subject"},{"id-type":"other","id":"1-74-2808-g2816","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-74","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2021,8,31]]},"article-number":"6"}}