{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T12:40:02Z","timestamp":1755866402401,"version":"3.44.0"},"reference-count":8,"publisher":"SMC Media","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Non-Hodgkin lymphomas of the hypothalamus and pituitary are rare. They usually remain clinically silent until onset of compressive features affecting surrounding structures. When symptomatic, patients most commonly present with diabetes insipidus, headaches, ophthalmoplegia and\/or bilateral hemianopia.\u00a0 We report a case of a 67-year-old Caucasian female with a history of B-cell lymphoma in complete remission. She presented with left oculomotor nerve palsy and was subsequently found to have a sellar\/suprasellar mass lesion on MRI. Alongside hypocortisolism and hypogonadotropic hypogonadism, she developed transient diabetes insipidus during her illness. Her clinical course was characterized by rapid intracranial progression of the sellar mass. MR spectroscopy suggested a diagnosis of lymphoma. Diagnostic biopsy confirmed high-grade diffuse large B-cell CNS lymphoma; this changed the definitive management from surgical excision to chemotherapy. Despite treatment, she succumbed to her illness within 7 months of initial presentation. This case highlights the aggressive nature of CNS lymphomas and the need for a high index of suspicion in an unusual presentation of sellar\/suprasellar mass lesions.<\/jats:p>","DOI":"10.12890\/2021_002980","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T03:54:40Z","timestamp":1640231680000},"source":"Crossref","is-referenced-by-count":2,"title":["Non-Hodgkin Lymphoma Causing Hypopituitarism Can Imaging Help Diagnosis and Management?"],"prefix":"10.12890","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5559-9300","authenticated-orcid":false,"given":"Uzma","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Diabetes, University Hospitals Coventry & Warwickshire NHS Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Borg","sequence":"additional","affiliation":[{"name":"Department of Haematology, South Warwickshire NHS Foundation Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radu","family":"Beltechi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospitals Coventry & Warwickshire NHS Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiten","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, University Hospitals Coventry & Warwickshire NHS Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Robbins","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Diabetes, University Hospitals Coventry & Warwickshire NHS Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harpal","family":"Randeva","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Diabetes, University Hospitals Coventry & Warwickshire NHS Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratibha","family":"Machenahalli","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Diabetes, University Hospitals Coventry & Warwickshire NHS Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"10.12890\/2021_002980_ref1","doi-asserted-by":"crossref","unstructured":"<li>Komninos J, Vlassopoulou V, Protopapa D, Korfias S, Kontogeorgos G, Sakas DE, et al. Tumors metastatic to the pituitary gland: case report and literature review. <em>J Clin Endocrinol Metab<\/em> 2004;<strong>89<\/strong>:574\u2013580. <\/li>","DOI":"10.1210\/jc.2003-030395"},{"key":"10.12890\/2021_002980_ref2","doi-asserted-by":"crossref","unstructured":"<li>Freda PU, Post KD. Differential diagnosis of sellar masses. <em>Endocrinol Metab Clin North Am<\/em> 1999;<strong>28<\/strong>:81\u2013117. <\/li>","DOI":"10.1016\/S0889-8529(05)70058-X"},{"key":"10.12890\/2021_002980_ref3","doi-asserted-by":"crossref","unstructured":"<li>He W, Chen F, Dalm B, Kirby PA, Greenlee JD. Metastatic involvement of the pituitary gland: a systematic review with pooled individual patient data analysis. <em>Pituitary <\/em>2015;<strong>18<\/strong>:159\u2013168. <\/li>","DOI":"10.1007\/s11102-014-0552-2"},{"key":"10.12890\/2021_002980_ref4","unstructured":"<li>Ntyonga-Pono MP, Thomopoulos P, Luton JP. Pituitary metastases. Three cases. <em>Presse Med<\/em> 1999;<strong>28<\/strong>:1567\u20131571. <\/li>"},{"key":"10.12890\/2021_002980_ref5","doi-asserted-by":"crossref","unstructured":"<li>Weinberg BD, Kuruva M, Shim H, Mullins ME. Clinical applications of magnetic resonance spectroscopy in brain tumors: from diagnosis to treatment. <em>Radiol Clin North Am<\/em> 2021;<strong>59<\/strong>(3):349\u2013362. <\/li>","DOI":"10.1016\/j.rcl.2021.01.004"},{"key":"10.12890\/2021_002980_ref6","doi-asserted-by":"crossref","unstructured":"<li>Bromberg JE, Doorduijn JK, Illerhaus G, Jahnke K, Korfel A, Fischer L, et al. Central nervous system recurrence of systemic lymphoma in the era of stem cell transplantation \u2013 an International Primary Central Nervous System Lymphoma Study Group project. <em>Haematologica<\/em> 2013;<strong>98<\/strong>(5):808\u2013813. <\/li>","DOI":"10.3324\/haematol.2012.070839"},{"key":"10.12890\/2021_002980_ref7","doi-asserted-by":"crossref","unstructured":"<li>Ferreri AJM. Therapy of primary CNS lymphoma: role of intensity, radiation, and novel agents. <em>Hematology Am Soc Hematol Educ Program<\/em> 2017;<strong>2017<\/strong>(1):565\u2013577.","DOI":"10.1182\/asheducation-2017.1.565"},{"key":"10.12890\/2021_002980_ref8","unstructured":"<\/li>"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2980\/2941","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2980\/2942","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2980\/2942","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T12:13:01Z","timestamp":1755864781000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/2980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,23]]},"references-count":8,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.12890\/2021_002980","relation":{"has-manifestation":[{"id-type":"other","id":"1-80-2980-g2941","asserted-by":"subject"},{"id-type":"other","id":"1-80-2980-g2942","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-80","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2021,12,23]]},"article-number":"2"}}