{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T12:40:03Z","timestamp":1755866403157,"version":"3.44.0"},"reference-count":10,"publisher":"SMC Media","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Copper deficiency or hypocupraemia is a rare cause of anaemia and neutropenia. Case description: We hereby present the case of a 34-year-old female with gastric bypass surgery who presented with neutropenic fever, abdominal pain and diarrhoea, later found to have extended-spectrum beta-lactamase resistant Escherichia coli urinary tract infection and small bowel bacterial overgrowth syndrome, with her anaemia and neutropenia being caused by copper deficiency due to hyperzincaemia induced by using zinc denture adhesive cream. Discussion: Various causes of copper deficiency have been recognized including, but not limited to, malnutrition, gastrectomy, gastric bypass surgery, protein-losing enteropathies (coeliac disease, tropical sprue), Wilson disease and Menkes syndrome. Copper deficiency caused by zinc overuse is not very prevalent. The haematologic abnormalities associated with copper deficiency are neutropenia, sideroblastic anaemia and\/or pancytopenia. Conclusion: Because of its low prevalence and nonspecific haematologic and clinical manifestations, the diagnosis of zinc-induced copper deficiency (ZICD) can be missed.<\/jats:p>","DOI":"10.12890\/2021_002983","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T06:55:15Z","timestamp":1638168915000},"source":"Crossref","is-referenced-by-count":2,"title":["Acquired Hyperzincaemia Due to Zinc-Laden Denture Adhesives Leading to Hypocupraemia as a Cause of Neutropenia"],"prefix":"10.12890","volume":"8","author":[{"given":"FNU","family":"Amisha","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prachi","family":"Saluja","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitesh","family":"Gautam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubham","family":"Biyani","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunilkumar","family":"Kakadia","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences, Little Rock, Arkansas, Unites States."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"key":"10.12890\/2021_002983_ref1","unstructured":"<li>Williams DM. Copper deficiency in humans. <em>Semin Hematol<\/em> 1983;<strong>20<\/strong>(2):118\u2013128.<\/li>"},{"key":"10.12890\/2021_002983_ref2","doi-asserted-by":"crossref","unstructured":"<li>Summerfield AL, Steinberg FU, Gonzalez JG. Morphologic findings in bone marrow precursor cells in zinc-induced copper deficiency anemia. <em>Am J Clin Pathol<\/em> 1992;<strong>97<\/strong>(5):665\u2013668. <\/li>","DOI":"10.1093\/ajcp\/97.5.665"},{"key":"10.12890\/2021_002983_ref3","doi-asserted-by":"crossref","unstructured":"<li>Fuhrman MP, Herrmann V, Masidonski P, Eby C. Pancytopenia after removal of copper from total parenteral nutrition. <em>JPEN J Parenter Enteral Nutr<\/em> 2000;<strong>24<\/strong>:361\u2013366. <\/li>","DOI":"10.1177\/0148607100024006361"},{"key":"10.12890\/2021_002983_ref4","doi-asserted-by":"crossref","unstructured":"<li>Willis MS, Monaghan SA, Miller ML, McKenna RW, Perkins WD, Levinson BS, et al. 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