{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:02:32Z","timestamp":1790877752120,"version":"4.1.0"},"reference-count":6,"publisher":"SMC Media","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Baboon syndrome, also called symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), is an erythematous maculopapular rash that presents in skin folds in a symmetrical pattern. This condition may develop after the patient starts a particular agent. Treatment consists of stopping the associated trigger and medicating with topical or systemic corticosteroids. A 30-year-old man with odynophagia, otalgia and fever was prescribed amoxicillin. He developed erythematous and pruriginous lesions in the cubital fossa and inguinal regions. He attended the emergency department (ED) where he was prescribed penicillin. Lesions continued to progressively worsen with a bilateral symmetrical pattern in the axillary region and later in the nape folds, popliteal regions, and on the perineum and buttocks. The patient presented to the ED for a second time, where he was diagnosed with baboon syndrome and prescribed topical steroids with clear improvement.<\/jats:p>","DOI":"10.12890\/2021_003029","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T04:56:15Z","timestamp":1638507375000},"source":"Crossref","is-referenced-by-count":3,"title":["Symmetrical Drug-related Intertriginous and Flexural Exanthema (Baboon Syndrome)"],"prefix":"10.12890","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0194-3628","authenticated-orcid":false,"given":"Olinda","family":"Lima Miranda","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Senhora da Oliveira, Guimaraes, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Martins","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Senhora da Oliveira, Guimaraes, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c2ngela","family":"Almeida","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Senhora da Oliveira, Guimaraes, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Formigo","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Senhora da Oliveira, Guimaraes, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Pereira","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Senhora da Oliveira, Guimaraes, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida","family":"Rocha","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Senhora da Oliveira, Guimaraes, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Cotter","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Senhora da Oliveira, Guimaraes, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10397","published-online":{"date-parts":[[2021,12,2]]},"reference":[{"key":"10.12890\/2021_003029_ref1","doi-asserted-by":"crossref","unstructured":"<li>Blackmur JP, Lammy S, Baring DEC. Baboon syndrome: an unusual complication arising from antibiotic treatment of tonsillitis and review of the literature. <em>BMJ Case Rep<\/em> 2013;<strong>2013<\/strong>:bcr2013201977. doi:10.1136\/bcr-2013-201977.<\/li>","DOI":"10.1136\/bcr-2013-201977"},{"key":"10.12890\/2021_003029_ref2","doi-asserted-by":"crossref","unstructured":"<li>Fischbach S, Hall N, Bains S, Selvaraj V. An unusual case of worsening cellulitis: baboon syndrome or SDRIFE. <em>BMJ Case Rep<\/em> 2018;<strong>2018<\/strong>:bcr2018224503. doi:10.1136\/bcr-2018-224503.<\/li>","DOI":"10.1136\/bcr-2018-224503"},{"key":"10.12890\/2021_003029_ref3","doi-asserted-by":"crossref","unstructured":"<li>Liu J, Li L-F. Symmetrical drug-related intertriginous and flexural exanthema\/baboon syndrome induced by traditional Chinese medicine. <em>J Cosmet Dermatol<\/em> 2021;<strong>00<\/strong>:1\u20135. https:\/\/doi.org\/10.1111\/jocd.14343.<\/li>","DOI":"10.1111\/jocd.14343"},{"key":"10.12890\/2021_003029_ref4","unstructured":"<li>Miyahara A, Kawashima H, Okubo Y, Hoshika A. A new proposal for a clinical-oriented subclassification of baboon syndrome and a review of baboon syndrome. <em>Asian Pac J Allergy Immunol <\/em>2011;<strong>29<\/strong>:150\u2013160.<\/li>"},{"key":"10.12890\/2021_003029_ref5","doi-asserted-by":"crossref","unstructured":"<li>Akkari H, Belhadjali H, Youssef M, Mokni S, Zili J. Baboon syndrome induced by hydroxyzine. <em>Indian J Dermatol<\/em> 2013;<strong>58<\/strong>:244.<\/li>","DOI":"10.4103\/0019-5154.110871"},{"key":"10.12890\/2021_003029_ref6","doi-asserted-by":"crossref","unstructured":"<li>Handisurya A, Stingl G, Wohrl S. SDRIFE (baboon syndrome) induced by penicillin. <em>Clin Exp Dermatol<\/em> 2009;<strong>34<\/strong>:355\u2013357. doi:10.1111\/j.1365-2230.2008.02911.x.<\/li>","DOI":"10.1111\/j.1365-2230.2008.02911.x"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3029\/2914","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3029\/2915","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3029\/2915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T12:13:22Z","timestamp":1755864802000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,2]]},"references-count":6,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.12890\/2021_003029","relation":{"has-manifestation":[{"id-type":"other","id":"1-80-3029-g2914","asserted-by":"subject"},{"id-type":"other","id":"1-80-3029-g2915","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-80","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,2]]},"article-number":"15"}}