{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:00:44Z","timestamp":1761562844620,"version":"3.44.0"},"reference-count":5,"publisher":"SMC Media","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Budd-Chiari syndrome (BCS) results from an occlusion of the hepatic venous flow which in turn leads to portal hypertension causing ascites and other signs of liver dysfunction. Here, we present the case of a 43-year-old woman with recurrent ascites who was found to have BCS secondary to an inferior vena cava thrombosis extending into the hepatic veins. Although she had a normal platelet count on admission, additional laboratory investigations revealed an MPL mutation. She was discharged on anticoagulation with apixaban and later found to have thrombocytosis on repeat blood work, confirming the diagnosis of essential thrombocytosis, following which she was started on myelosuppressive therapy with hydroxyurea.<\/jats:p>","DOI":"10.12890\/2021_003081","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T04:12:51Z","timestamp":1639714371000},"source":"Crossref","is-referenced-by-count":3,"title":["MPL-Positive Essential Thrombocytosis Presenting as Budd-Chiari Syndrome in a Middle-Aged Woman with an Initially Normal Platelet Count"],"prefix":"10.12890","volume":"8","author":[{"given":"Mohammad","family":"Ammad Ud Din","sequence":"additional","affiliation":[{"name":"Internal Medicine, Rochester General Hospital, Rochester, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hania","family":"Liaqat","sequence":"additional","affiliation":[{"name":"Internal Medicine, Rochester General Hospital, Rochester, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Osama","sequence":"additional","affiliation":[{"name":"Internal Medicine, Rochester General Hospital, Rochester, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2021,12,17]]},"reference":[{"key":"10.12890\/2021_003081_ref1","doi-asserted-by":"crossref","unstructured":"<li>Chait Y, Condat B, Cazals-Hatem D, Rufat P, Atmani S, Chaoui D, et al. Relevance of the criteria commonly used to diagnose myeloproliferative disorder in patients with splanchnic vein thrombosis. <em>Br J Haematol<\/em> 2005;<strong>129<\/strong>(4):553\u2013560.<\/li>","DOI":"10.1111\/j.1365-2141.2005.05490.x"},{"key":"10.12890\/2021_003081_ref2","doi-asserted-by":"crossref","unstructured":"<li>Rumi E, Cazzola E. How I treat essential thrombocythemia. <em>Blood<\/em> 2016;<strong>128<\/strong>(20):2403\u20132414.<\/li>","DOI":"10.1182\/blood-2016-05-643346"},{"key":"10.12890\/2021_003081_ref3","doi-asserted-by":"crossref","unstructured":"<li>Tefferi A, Lasho TL, Finke CM, Knudson RA, Ketterling R, Hanson CH, et al. CALR vs JAK2 vs MPL-mutated or triple-negative myelofibrosis: clinical, cytogenetic and molecular comparisons. <em>Leukemia<\/em> 2014;<strong>28<\/strong>(7):1472\u20131477.<\/li>","DOI":"10.1038\/leu.2014.3"},{"key":"10.12890\/2021_003081_ref4","doi-asserted-by":"crossref","unstructured":"<li>Tantawy AA-G, Adly AA-M, Elhenawy YI. Budd\u2013Chiari syndrome complicating essential thrombocythemia in an adolescent. <em>Blood Coagul Fibrinolysis<\/em> 2015;<strong>26<\/strong>(6):691\u2013694.<\/li>","DOI":"10.1097\/MBC.0000000000000325"},{"key":"10.12890\/2021_003081_ref5","doi-asserted-by":"crossref","unstructured":"<li>Ammad Ud Din M, Hussain SA, Jamshed S. Leg ulcer with long-term hydroxyurea use. <em>Clin Case Rep<\/em> 2021;<strong>9<\/strong>:2487\u20132488.<\/li>","DOI":"10.1002\/ccr3.3991"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3081\/2933","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3081\/2934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3081\/2934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T12:13:10Z","timestamp":1755864790000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,17]]},"references-count":5,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.12890\/2021_003081","relation":{"has-manifestation":[{"id-type":"other","id":"1-80-3081-g2933","asserted-by":"subject"},{"id-type":"other","id":"1-80-3081-g2934","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-80","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2021,12,17]]},"article-number":"6"}}