{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:07:14Z","timestamp":1755907634529,"version":"3.44.0"},"reference-count":8,"publisher":"SMC Media","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Pituitary adenomas are the most common cause of hypopituitarism associated with pituitary enlargement, but other aetiologies have been emerging, namely immune checkpoint inhibitor-induced hypophysitis (ipilimumab, nivolumab and pembrolizumab). Secukinumab is a recently approved human monoclonal antibody used for the treatment of psoriasis, with no know reported cases of hypophysitis. We describe a challenging case of panhypopituitarism in a patient with a pituitary incidentaloma and a temporal relationship between secukinumab initiation and the manifestation of clinical features suggestive of hypopituitarism. In such intricate work-up, the differential diagnoses should be carefully considered, taking into account the therapeutic and prognostic implications.<\/jats:p>","DOI":"10.12890\/2021_003099","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T03:48:21Z","timestamp":1640922501000},"source":"Crossref","is-referenced-by-count":1,"title":["Secukinumab, Pituitary Enlargement and Panhypopituitarism: Are They Related?"],"prefix":"10.12890","volume":"8","author":[{"given":"Diogo","family":"Ramalho","sequence":"first","affiliation":[{"name":"Endocrinology Department, Centro Hospitalar de Vila Nova de Gaia\/Espinho, Vila Nova de Gaia, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Ara\u00fajo","sequence":"first","affiliation":[{"name":"Neuroradiology Department, Centro Hospitalar de Vila Nova de Gaia\/Espinho, Vila Nova de Gaia, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Rocha","sequence":"first","affiliation":[{"name":"Endocrinology Department, Centro Hospitalar de Vila Nova de Gaia\/Espinho, Vila Nova de Gaia, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filipa","family":"Duarte-Ribeiro","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Centro Hospitalar de Vila Nova de Gaia\/Espinho, Vila Nova de Gaia, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2021,12,31]]},"reference":[{"key":"10.12890\/2021_003099_ref1","doi-asserted-by":"crossref","unstructured":"<li>Gutenberg A, Larsen J, Lupi I, Rohde V, Caturegli P. A radiologic score to distinguish autoimmune hypophysitis from nonsecreting pituitary adenoma preoperatively. <em>AJNR Am J Neuroradiol<\/em> 2009;<strong>30<\/strong>(9):1766\u20131772.<\/li>","DOI":"10.3174\/ajnr.A1714"},{"key":"10.12890\/2021_003099_ref2","doi-asserted-by":"crossref","unstructured":"<li>Freda PU, Beckers AM, Katznelson L, Molitch ME, Montori VM, Post KD, et al. Pituitary incidentaloma: an Endocrine Society clinical practice guideline. <em>J Clin Endocrinol Metab<\/em> 2011;<strong>96<\/strong>(4):894\u2013904.<\/li>","DOI":"10.1210\/jc.2010-1048"},{"key":"10.12890\/2021_003099_ref3","doi-asserted-by":"crossref","unstructured":"<li>Joshi MN, Whitelaw BC, Carroll PV. MECHANISMS IN ENDOCRINOLOGY: Hypophysitis: diagnosis and treatment. <em>Eur J Endocrinol<\/em> 2018;<strong>179<\/strong>(3):R151\u2013R163.<\/li>","DOI":"10.1530\/EJE-17-0009"},{"key":"10.12890\/2021_003099_ref4","doi-asserted-by":"crossref","unstructured":"<li>Yang EJ, Beck KM, Liao W. Secukinumab in the treatment of psoriasis: patient selection and perspectives. <em>Psoriasis (Auckl) <\/em>2018;<strong>8<\/strong>:75\u201382.<\/li>","DOI":"10.2147\/PTT.S146004"},{"key":"10.12890\/2021_003099_ref5","doi-asserted-by":"crossref","unstructured":"<li>Beringer A, Noack M, Miossec P. IL-17 in chronic inflammation: from discovery to targeting. <em>Trends Mol Med<\/em> 2016;<strong>22<\/strong>(3):230\u2013241.<\/li>","DOI":"10.1016\/j.molmed.2016.01.001"},{"key":"10.12890\/2021_003099_ref6","doi-asserted-by":"crossref","unstructured":"<li>Hueber W, Sands BE, Lewitzky S, Vandemeulebroecke M, Reinisch W, Higgins PD, et al. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. <em>Gut<\/em> 2012;<strong>61<\/strong>(12):1693\u20131700.<\/li>","DOI":"10.1136\/gutjnl-2011-301668"},{"key":"10.12890\/2021_003099_ref7","doi-asserted-by":"crossref","unstructured":"<li>Ramos-Levi AM, Gargallo M, Serrano-Somavilla A, Sampedro-Nunez MA, Fraga J, Marazuela M. Hypophysitis following treatment with ustekinumab: radiological and pathological findings. <em>Front Endocrinol (Lausanne)<\/em> 2018;<strong>9<\/strong>:83.<\/li>","DOI":"10.3389\/fendo.2018.00083"},{"key":"10.12890\/2021_003099_ref8","doi-asserted-by":"crossref","unstructured":"<li>Esposito D, Olsson DS, Ragnarsson O, Buchfelder M, Skoglund T, Johannsson G. Non-functioning pituitary adenomas: indications for pituitary surgery and post-surgical management. <em>Pituitary<\/em> 2019;<strong>22<\/strong>(4):422\u2013434.<\/li>","DOI":"10.1007\/s11102-019-00960-0"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3099\/2953","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3099\/2954","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3099\/2954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T12:12:54Z","timestamp":1755864774000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,31]]},"references-count":8,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.12890\/2021_003099","relation":{"has-manifestation":[{"id-type":"other","id":"1-80-3099-g2953","asserted-by":"subject"},{"id-type":"other","id":"1-80-3099-g2954","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-80","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2021,12,31]]}}}