{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:11:20Z","timestamp":1784553080070,"version":"3.55.0"},"reference-count":9,"publisher":"SMC Media","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Bullous pemphigoid is a rare autoimmune dermatologic disease that usually occurs in the elderly. Mucous membrane lesions occur in about 10\u201335% of patients and are almost always limited to the oral mucous membrane. Esophageal involvement is very rare (4% of cases) and usually presents with chest pain, dysphagia, and odynophagia, though patients are frequently asymptomatic. We report the case of newly diagnosed bullous pemphigoid in a 76-year-old man with a past medical history of dementia. He presented with cutaneous manifestations but also severe gastrointestinal bleeding due to extensive esophageal involvement. Although bullous pemphigoid is mainly a skin disease, mucous membrane lesions should not be overlooked as they are associated with an even poorer outcome. A high index of suspicion for esophageal involvement is needed as its presentation can be fatal, as with our patient.<\/jats:p>","DOI":"10.12890\/2022_003160","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T03:47:56Z","timestamp":1643687276000},"source":"Crossref","is-referenced-by-count":5,"title":["Esophageal Bullous Pemphigoid"],"prefix":"10.12890","volume":"9","author":[{"given":"Catarina","family":"Castelo Branco","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Centro Hospitalar Universit\u00e1rio do Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1s","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Centro Hospitalar Universit\u00e1rio do Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Marcos-Pinto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Centro Hospitalar Universit\u00e1rio do Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10397","published-online":{"date-parts":[[2022,2,1]]},"reference":[{"key":"10.12890\/2022_003160_ref1","doi-asserted-by":"crossref","unstructured":"<li>Miyamoto D, Santi CG, Aoki V, Maruta CW. Bullous pemphigoid. <em>An Bras Dermatol<\/em> 2019;<strong>94<\/strong>(2):133\u2013146.<\/li>","DOI":"10.1590\/abd1806-4841.20199007"},{"key":"10.12890\/2022_003160_ref2","doi-asserted-by":"crossref","unstructured":"<li>Schmidt E, Zillikens D. Pemphigoid diseases. <em>Lancet<\/em> 2013;<strong>381<\/strong>(9863):320\u2013332.<\/li>","DOI":"10.1016\/S0140-6736(12)61140-4"},{"key":"10.12890\/2022_003160_ref3","doi-asserted-by":"crossref","unstructured":"<li>Lai YC, Yew YW, Lambert WC. Bullous pemphigoid and its association with neurological diseases: a systematic review and meta-analysis. <em>J Eur Acad Dermatol Venereol<\/em> 2016;<strong>30<\/strong>(12):2007\u20132015.<\/li>","DOI":"10.1111\/jdv.13660"},{"key":"10.12890\/2022_003160_ref4","doi-asserted-by":"crossref","unstructured":"<li>Gaspar R, Moutinho-Ribeiro P, Macedo G. Bullous pemphigoid: extensive esophageal involvement. <em>Gastrointest Endosc<\/em> 2017;<strong>86<\/strong>(2):400\u2013402.<\/li>","DOI":"10.1016\/j.gie.2017.02.015"},{"key":"10.12890\/2022_003160_ref5","doi-asserted-by":"crossref","unstructured":"<li>S\u00e1rdy M, Kostaki D, Varga R, Peris K, Ruzicka T. Comparative study of direct and indirect immunofluorescence and of bullous pemphigoid 180 and 230 enzyme-linked immunosorbent assays for diagnosis of bullous pemphigoid.<em> J Am Acad Dermatol<\/em> 2013;<strong>69<\/strong>(5):748\u2013753.<\/li>","DOI":"10.1016\/j.jaad.2013.07.009"},{"key":"10.12890\/2022_003160_ref6","doi-asserted-by":"crossref","unstructured":"<li>Venning VA, Taghipour K, Mohd Mustapa MF, Highet AS, Kirtschig G. British Association of Dermatologists\u2019 guidelines for the management of bullous pemphigoid 2012. <em>Br J Dermatol<\/em> 2012;<strong>167<\/strong>(6):1200\u20131214.<\/li>","DOI":"10.1111\/bjd.12072"},{"key":"10.12890\/2022_003160_ref7","doi-asserted-by":"crossref","unstructured":"<li>Amagai M, Ikeda S, Hashimoto T, Mizuashi M, Fujisawa A, Ihn H, et al. A randomized double-blind trial of intravenous immunoglobulin for bullous pemphigoid. <em>J Dermatol Sci<\/em> 2017; <strong>85<\/strong>(2):77\u201384.<\/li>","DOI":"10.1016\/j.jdermsci.2016.11.003"},{"key":"10.12890\/2022_003160_ref8","doi-asserted-by":"crossref","unstructured":"<li>Holtsche MM, Goletz S, van Beek N, Zillikens D, Benoit S, Harman K, et al. Prospective study in bullous pemphigoid: association of high serum anti-BP180 IgG levels with increased mortality and reduced Karnofsky score. <em>Br J Dermatol <\/em>2018;<strong>179<\/strong>(4):918\u2013924.<\/li>","DOI":"10.1111\/bjd.16553"},{"key":"10.12890\/2022_003160_ref9","doi-asserted-by":"crossref","unstructured":"<li>Bystryn JC, Rudolph JL. Why is the mortality of bullous pemphigoid greater in Europe than in the US? <em>J Invest Dermatol<\/em>, 2005;<strong>124<\/strong>(3):xx\u2013xxi.<\/li>","DOI":"10.1111\/j.0022-202X.2005.23677.x"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3160\/2985","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3160\/2986","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3160\/2986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T11:53:14Z","timestamp":1755863594000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,1]]},"references-count":9,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.12890\/2022_003160","relation":{"has-manifestation":[{"id-type":"other","id":"1-82-3160-g2985","asserted-by":"subject"},{"id-type":"other","id":"1-82-3160-g2986","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-82","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,1]]},"article-number":"25"}}