{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:07:00Z","timestamp":1755907620804,"version":"3.44.0"},"reference-count":6,"publisher":"SMC Media","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Background: Mild encephalitis\/encephalopathy and a reversible splenial lesion (MERS) is a clinicoradiological syndrome with an unknown pathogenic mechanism, which usually involves children. Thus, adult-onset MERS is quite rare. Case presentation: A 71-year-old man, undergoing haemodialysis due to diabetes-induced chronic kidney disease, manifested a persistent fever and disorientation. Blood culture detected methicillin-resistant Staphylococcus aureus (MRSA), while echocardiography revealed vegetation in the aortic and mitral valves. Magnetic resonance imaging of the head revealed a fluid-attenuated inversion recovery-high, diffusion-weighted image-high lesion in the splenium of the corpus callosum, with a number of emboli. Accordingly, the patient was diagnosed with MERS induced by MRSA endocarditis. Discussion: Neurological impairment by MERS can be reversible. However, the differential diagnosis of the disease includes ischaemic lesions, multiple sclerosis, malignant lymphoma, acute disseminated encephalomyelitis, and posterior reversible encephalopathy. Clinicians should consider these diseases when MERS is suspected.<\/jats:p>","DOI":"10.12890\/2022_003185","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T03:52:43Z","timestamp":1645761163000},"source":"Crossref","is-referenced-by-count":1,"title":["Adult-onset Mild Encephalitis\/Encephalopathy with a Reversible Splenial Lesion Induced by MRSA Endocarditis"],"prefix":"10.12890","volume":"9","author":[{"given":"Hideharu","family":"Hagiya","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"10.12890\/2022_003185_ref1","doi-asserted-by":"crossref","unstructured":"<li>Tada H, Takanashi J, Barkovich AJ, Oba H, Maeda M, Tsukahara H, et al. Clinically mild encephalitis\/encephalopathy with a reversible splenial lesion. <em>Neurology<\/em> 2004;<strong>63<\/strong>:1854\u20131858.<\/li>","DOI":"10.1212\/01.WNL.0000144274.12174.CB"},{"key":"10.12890\/2022_003185_ref2","doi-asserted-by":"crossref","unstructured":"<li>Takanashi J. Two newly proposed infectious encephalitis\/encephalopathy syndromes. <em>Brain Dev<\/em> 2009;<strong>31<\/strong>:521\u2013528.<\/li>","DOI":"10.1016\/j.braindev.2009.02.012"},{"key":"10.12890\/2022_003185_ref3","doi-asserted-by":"crossref","unstructured":"<li>Yuan J, Yang S, Wang S, Qin W, Yang L, Hu W. Mild encephalitis\/encephalopathy with reversible splenial lesion (MERS) in adults\u2013a case report and literature review. <em>BMC Neurol<\/em> 2017;<strong>17<\/strong>:103.<\/li>","DOI":"10.1186\/s12883-017-0875-5"},{"key":"10.12890\/2022_003185_ref4","unstructured":"<li>Takanashi J, Barkovich A, Shiihara T, Tada H, Kawatani M, Tsukahara H, et al. Widening spectrum of a reversible splenial lesion with transiently reduced diffusion. <em>Am J Neuroradiol<\/em> 2006;<strong>27<\/strong>:836\u2013838.<\/li>"},{"key":"10.12890\/2022_003185_ref5","doi-asserted-by":"crossref","unstructured":"<li>Anada R, Nukui T, Hayashi T, Konishi H, Dougu N, Nakatsuji Y. A case of clinically mild encephalitis\/encephalopathy with a reversible splenial lesion (MERS) associated with infectious endocarditis caused by <em>Staphylococcus aureus<\/em>. <em>Rinsho Shinkeigaku<\/em> 2019;<strong>59<\/strong>:666\u2013668 <sup>[in Japanese]<\/sup>.<\/li>","DOI":"10.5692\/clinicalneurol.cn-001335"},{"key":"10.12890\/2022_003185_ref6","doi-asserted-by":"crossref","unstructured":"<li>Pan JJ, Zhao YY, Lu C, Hu YH, Yang Y. Mild encephalitis\/encephalopathy with a reversible splenial lesion: five cases and a literature review. <em>Neurol Sci<\/em> 2015;<strong>36<\/strong>:2043\u20132051.<\/li>","DOI":"10.1007\/s10072-015-2302-2"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3185\/3025","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3185\/3026","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3185\/3026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T11:52:34Z","timestamp":1755863554000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,25]]},"references-count":6,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.12890\/2022_003185","relation":{"has-manifestation":[{"id-type":"other","id":"1-82-3185-g3025","asserted-by":"subject"},{"id-type":"other","id":"1-82-3185-g3026","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-82","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2022,2,25]]},"article-number":"5"}}