{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T12:10:01Z","timestamp":1755864601637,"version":"3.44.0"},"reference-count":12,"publisher":"SMC Media","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Escitalopram is a commonly prescribed medication that has infrequently been implicated in drug-induced thrombocytopenia (DITP) but has never been associated with aplastic anaemia in the literature. We present an extremely rare case of hypoproliferative pancytopenia due to self-administered intravenous (IV) injection of escitalopram. The crux of this case is the unusual trilineage cytopenia. Our patient was managed with steroids and supportive care with subsequent clinical and blood count recovery. This case sheds light on this uncommon but important association.<\/jats:p>","DOI":"10.12890\/2022_003228","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T03:33:33Z","timestamp":1646364813000},"source":"Crossref","is-referenced-by-count":2,"title":["Serotonin Surge: Intravenous Escitalopram as a Rare Cause of Drug-Induced Aplastic Anaemia"],"prefix":"10.12890","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4641-800X","authenticated-orcid":false,"given":"Murtaza","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Michigan State University at Hurley Medical Center, Flint, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5947-4057","authenticated-orcid":false,"given":"Katherine","family":"Boyer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anoosha","family":"Ponnapalli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Michigan State University at Hurley Medical Center, Flint, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic","family":"Awuah","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Michigan State University at Hurley Medical Center, Flint, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina","family":"Khaneki","sequence":"additional","affiliation":[{"name":"Internal Medicine Physician at Kaiser Permanente, Lincoln, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5239-9533","authenticated-orcid":false,"given":"Smit","family":"Deliwala","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Michigan State University at Hurley Medical Center, Flint, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6763-4508","authenticated-orcid":false,"given":"Ghassan","family":"Bachuwa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Michigan State University at Hurley Medical Center, Flint, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2022,3,4]]},"reference":[{"key":"10.12890\/2022_003228_ref1","doi-asserted-by":"crossref","unstructured":"<li>Young NS. Acquired aplastic anemia. Ann Intern Med 2002;136(7):534\u2013546.<\/li>","DOI":"10.7326\/0003-4819-136-7-200204020-00011"},{"key":"10.12890\/2022_003228_ref2","doi-asserted-by":"crossref","unstructured":"<li>Bosch X, Vera M. Aplastic anaemia during treatment with fluoxetine. <em>Lancet<\/em> 1998;<strong>351<\/strong>(9108):1031.<\/li>","DOI":"10.1016\/S0140-6736(05)78997-2"},{"key":"10.12890\/2022_003228_ref3","doi-asserted-by":"crossref","unstructured":"<li>Vilinsky FD, Lubin A. Severe neutropenia associated with fluoxetine hydrochloride. <em>Ann Intern Med<\/em> 1997;<strong>127<\/strong>(7):573\u2013574.<\/li>","DOI":"10.7326\/0003-4819-127-7-199710010-00018"},{"key":"10.12890\/2022_003228_ref4","doi-asserted-by":"crossref","unstructured":"<li>Chu C-W, Chao P-C, Chang H-A, Liu Y-W, Chang T-C, Lin P-Y, et al. 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Common polymorphic deletion of glutathione S-transferase theta predisposes to acquired aplastic anemia: independent cohort and meta-analysis of 609 patients. <em>Am J Hematol<\/em> 2013;<strong>88<\/strong>(10):862\u2013867.<\/li>","DOI":"10.1002\/ajh.23521"},{"key":"10.12890\/2022_003228_ref8","unstructured":"<li>Al Qahtani SA. Drug-induced megaloblastic, aplastic, and hemolytic anemias: current concepts of pathophysiology and treatment. <em>Int J Clin Exp Med<\/em> 2018;<strong>11<\/strong>(6):5501\u20135512.<\/li>"},{"key":"10.12890\/2022_003228_ref9","doi-asserted-by":"crossref","unstructured":"<li>Carey PJ. Drug-induced myelosuppression. Drug Saf 2003;26(10):691\u2013706.<\/li>","DOI":"10.2165\/00002018-200326100-00003"},{"key":"10.12890\/2022_003228_ref10","doi-asserted-by":"crossref","unstructured":"<li>Aster RH, Bougie DW. Drug-induced immune thrombocytopenia. <em>N Engl J Med<\/em> 2007;<strong>357<\/strong>(6):580\u2013587.<\/li>","DOI":"10.1056\/NEJMra066469"},{"key":"10.12890\/2022_003228_ref11","unstructured":"<li>LiverTox: clinical and research information on drug-induced liver injury [Internet]. Adverse Drug Reaction Probability Scale (Naranjo) in drug induced liver injury [updated 4 May 2019]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548069\/<\/li>"},{"key":"10.12890\/2022_003228_ref12","doi-asserted-by":"crossref","unstructured":"<li>Kumar R, Bonfim C, George B. Hematopoietic cell transplantation for aplastic anemia. <em>Curr Opin Hematol<\/em> 2017;<strong>24<\/strong>(6):509\u2013514.<\/li>","DOI":"10.1097\/MOH.0000000000000382"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3228\/3038","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3228\/3039","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3228\/3039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T11:35:36Z","timestamp":1755862536000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,4]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.12890\/2022_003228","relation":{"has-manifestation":[{"id-type":"other","id":"1-83-3228-g3038","asserted-by":"subject"},{"id-type":"other","id":"1-83-3228-g3039","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-83","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2022,3,4]]},"article-number":"12"}}