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Here we describe a sickle cell disease patient with avascular necrosis who presented with persistent bacteraemia due to C. difficile and septic arthritis in a native knee joint, which responded very well to medical and surgical treatment but recurred multiple times within weeks of the cessation of antibiotics.<\/jats:p>","DOI":"10.12890\/2022_003243","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T04:53:47Z","timestamp":1647492827000},"source":"Crossref","is-referenced-by-count":0,"title":["Clostridioides difficile Bacteraemia and Septic Arthritis in a Sickle Cell Disease Patient"],"prefix":"10.12890","volume":"9","author":[{"given":"Moayad","family":"Alqurashi","sequence":"additional","affiliation":[{"name":"Division of Adult Infectious Diseases, Department of Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Badr","family":"Madani","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Mursi","sequence":"additional","affiliation":[{"name":"Division of Adult Infectious Diseases, Department of Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazik","family":"Eltayeb","sequence":"additional","affiliation":[{"name":"Division of Adult Infectious Diseases, Department of Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"10.12890\/2022_003243_ref1","doi-asserted-by":"crossref","unstructured":"<li>Gajd\u00e1cs M, \u00c1br\u00f3k M, L\u00e1z\u00e1r A, Terhes G, Urb\u00e1n E. Anaerobic blood culture positivity at a university hospital in Hungary: a 5-year comparative retrospective study. <em>Anaerobe<\/em> 2020;<strong>63<\/strong>:102200. <\/li>","DOI":"10.1016\/j.anaerobe.2020.102200"},{"key":"10.12890\/2022_003243_ref2","doi-asserted-by":"crossref","unstructured":"<li>Legendre P, Lalande V, Eckert C, Barbut F, Fardet L, Meynard J, et al. Clostridium difficile associated reactive arthritis: case report and literature review. <em>Anaerobe<\/em> 2016;<strong>38<\/strong>:76\u201380. <\/li>","DOI":"10.1016\/j.anaerobe.2015.12.011"},{"key":"10.12890\/2022_003243_ref3","doi-asserted-by":"crossref","unstructured":"<li>Urb\u00e1n E, Terhes G, Gajd\u00e1cs M. Extraintestinal Clostridioides difficile infections: epidemiology in a university hospital in Hungary and review of the literature.<em> Antibiotics (Basel)<\/em> 2020;<strong>9<\/strong>(1):16. <\/li>","DOI":"10.3390\/antibiotics9010016"},{"key":"10.12890\/2022_003243_ref4","doi-asserted-by":"crossref","unstructured":"<li>Basnet N, Thapaliya S, Shrotriya S, Kar P, Mitra S. Extraintestinal Clostridium difficile infection: scrotal abscess. <em>Anaerobe<\/em> 2020;<strong>61<\/strong>:102147. <\/li>","DOI":"10.1016\/j.anaerobe.2019.102147"},{"key":"10.12890\/2022_003243_ref5","doi-asserted-by":"crossref","unstructured":"<li>Chaudhry R, Khullar S, Arif N, Sagar T, Meena D, Kumar Chowdhury U. <em>Clostridioides difficile<\/em> from intracardiac vegetation. <em>Anaerobe<\/em> 2021;<strong>69<\/strong>:102350. <\/li>","DOI":"10.1016\/j.anaerobe.2021.102350"},{"key":"10.12890\/2022_003243_ref6","doi-asserted-by":"crossref","unstructured":"<li>Pron B, Merckx J, Touzet P, Ferroni A, Poyart C, Berche P, et al. Chronic septic arthritis and osteomyelitis in a prosthetic knee joint due to Clostridium difficile. <em>Eur J Clin Microbiol Infect Dis<\/em> 1995;<strong>14<\/strong>(7):599\u2013601. <\/li>","DOI":"10.1007\/BF01690732"},{"key":"10.12890\/2022_003243_ref7","doi-asserted-by":"crossref","unstructured":"<li>Amaya S-L, Rosa E-S, Sergio G-F, Noelia A, Lourdes R-R, Eduardo G, et al. Extraintestinal Clostridioides difficile infection: septic arthritis 12 months after colitis. <em>Anaerobe<\/em> 2021;<strong>69<\/strong>:102318. <\/li>","DOI":"10.1016\/j.anaerobe.2021.102318"},{"key":"10.12890\/2022_003243_ref8","doi-asserted-by":"crossref","unstructured":"<li>Eustace MB, Jennison AV, McCarthy KL. Septic arthritis post anterior cruciate ligament reconstruction due to Clostridioides difficile. <em>Anaerobe<\/em> 2020;<strong>66<\/strong>:102293. <\/li>","DOI":"10.1016\/j.anaerobe.2020.102293"},{"key":"10.12890\/2022_003243_ref9","unstructured":"<li>Selvanderan SP, Goldblatt F, Nguyen NQ, Costello SP. Faecal microbiota transplantation for Clostridium difficile infection resulting in a decrease in psoriatic arthritis disease activity. <em>Clin Exp Rheumatol<\/em> 1996;<strong>37<\/strong>(3):514\u2013515. <\/li>"},{"key":"10.12890\/2022_003243_ref10","doi-asserted-by":"crossref","unstructured":"<li>Kennedy N, Chambers ST, Nolan I, Gallagher K, Werno A, Browne M, et al. Native joint septic arthritis: epidemiology, clinical features, and microbiological causes in a New Zealand population. <em>J Rheumatol<\/em> 2015;<strong>42<\/strong>(12):2392\u20132397. <\/li>","DOI":"10.3899\/jrheum.150434"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3243\/3058","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3243\/3059","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3243\/3059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T11:35:26Z","timestamp":1755862526000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,17]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.12890\/2022_003243","relation":{"has-manifestation":[{"id-type":"other","id":"1-83-3243-g3058","asserted-by":"subject"},{"id-type":"other","id":"1-83-3243-g3059","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-83","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2022,3,17]]},"article-number":"2"}}