{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T02:18:10Z","timestamp":1771553890842,"version":"3.50.1"},"reference-count":12,"publisher":"SMC Media","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Hypotension in patients with heart failure is much more frequent in daily clinical practice than the 10\u201315% reported in clinical trials. In patients with heart failure with reduced ejection fraction (HFrEF), hypotension frequently limits the initiation and up-titration of guideline-directed medical therapy (GDMT). Midodrine is a peripheral alpha-1 agonist and a vasopressor anti-hypotensive agent approved for the treatment of orthostatic hypotension. We describe two cases where midodrine was prescribed in patients with HFrEF and hypotension.<\/jats:p>","DOI":"10.12890\/2022_003246","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T06:03:03Z","timestamp":1647583383000},"source":"Crossref","is-referenced-by-count":3,"title":["Use of Midodrine in Heart Failure: Two Case Reports and a Review of the Literature"],"prefix":"10.12890","volume":"9","author":[{"given":"Adnan","family":"Hajjiah","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Department, Ahmadi Hospital \u2013 Kuwait Oil Company, Al Ahmadi, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ossama","family":"Maadarani","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Ahmadi Hospital \u2013 Kuwait Oil Company, Al Ahmadi, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zouheir","family":"Bitar","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Ahmadi Hospital \u2013 Kuwait Oil Company, Al Ahmadi, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boutros","family":"Hanna","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Ahmadi Hospital \u2013 Kuwait Oil Company, Al Ahmadi, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ragab","family":"Elshabasy","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Ahmadi Hospital \u2013 Kuwait Oil Company, Al Ahmadi, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Abdelfatah","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Ahmadi Hospital \u2013 Kuwait Oil Company, Al Ahmadi, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Gohar","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Ahmadi Hospital \u2013 Kuwait Oil Company, Al Ahmadi, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2022,3,18]]},"reference":[{"key":"10.12890\/2022_003246_ref1","doi-asserted-by":"crossref","unstructured":"<li>CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). <em>N Engl J Med<\/em> 1987;<strong>316<\/strong>:1429\u20131435.<\/li>","DOI":"10.1056\/NEJM198706043162301"},{"key":"10.12890\/2022_003246_ref2","doi-asserted-by":"crossref","unstructured":"<li>Komajda M, Schope J, Wagenpfeil S, Tavazzi L, Bohm M, Ponikowski P, et al.; QUALIFY Investigators. Physicians\u2019 guideline adherence is associated with long-term heart failure mortality in outpatients with heart failure with reduced ejection fraction: the QUALIFY international registry. <em>Eur J Heart Fail<\/em> 2019;<strong>21<\/strong>:921\u2013929.<\/li>","DOI":"10.1002\/ejhf.1459"},{"key":"10.12890\/2022_003246_ref3","doi-asserted-by":"crossref","unstructured":"<li>Ambrosy AP, Vaduganathan M, Mentz RJ, Greene SJ, Subacius H, Konstam MA, et al. Clinical profile and prognostic value of low systolic blood pressure in patients hospitalized for heart failure with reduced ejection fraction: insights from the Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan (EVEREST) trial. <em>Am Heart J<\/em> 2013;<strong>165<\/strong>:216\u2013225.<\/li>","DOI":"10.1016\/j.ahj.2012.11.004"},{"key":"10.12890\/2022_003246_ref4","doi-asserted-by":"crossref","unstructured":"<li>Tartiere JM, Logeart D, Safar ME, Cohen-Solal A. Interaction between pulse wave velocity, augmentation index, pulse pressure and left ventricular function in chronic heart failure. <em>J Hum Hypertens<\/em> 2006;<strong>20<\/strong>:213\u2013219.<\/li>","DOI":"10.1038\/sj.jhh.1001965"},{"key":"10.12890\/2022_003246_ref5","unstructured":"National Library of Medicine - PubChem. Midodrine hydrochloride. Available from https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Midodrine-hydrochloride.<\/li>"},{"key":"10.12890\/2022_003246_ref6","doi-asserted-by":"crossref","unstructured":"<li>Prakash S, Garg AX, Heidenheim AP, House AA. Midodrine appears to be safe and effective for dialysis-induced hypotension: a systematic review. <em>Nephrol Dial Transplant <\/em>2004 Oct;<strong>19<\/strong>(10):2553\u20132558. doi: 10.1093\/ndt\/gfh420, PMID: 15280522.<\/li>","DOI":"10.1093\/ndt\/gfh420"},{"key":"10.12890\/2022_003246_ref7","doi-asserted-by":"crossref","unstructured":"<li>Brunelli SM, Cohen DE, Marlowe G, Van Wyck D. The impact of midodrine on outcomes in patients with intradialytic hypotension. <em>Am J Nephrol<\/em> 2018;<strong>48<\/strong>(5):381\u2013388. doi: 10.1159\/000494806, PMID: 30423552.<\/li>","DOI":"10.1159\/000494806"},{"key":"10.12890\/2022_003246_ref8","doi-asserted-by":"crossref","unstructured":"<li>Scoma C, Dae-Hyun L, Cohen A, Fernandez J. Prevalence of midodrine use in patients admitted with systolic congestive heart. <em>J Am Coll Cardiol<\/em> 2021;<strong>77<\/strong>(18):678. doi: 10.1016\/S0735-1097(21)02037-4.<\/li>","DOI":"10.1016\/S0735-1097(21)02037-4"},{"key":"10.12890\/2022_003246_ref9","doi-asserted-by":"crossref","unstructured":"<li>Zakir RM, Folefack A, Saric M, Berkowitz RL. The use of midodrine in patients with advanced heart failure. <em>Congest Heart Fail<\/em> 2009 May-Jun;<strong>15<\/strong>(3):108\u2013111. doi: 10.1111\/j.1751-7133.2008.00042.x, PMID: 19522958.<\/li>","DOI":"10.1111\/j.1751-7133.2008.00042.x"},{"key":"10.12890\/2022_003246_ref10","doi-asserted-by":"crossref","unstructured":"<li>Folefack A, Zakir RM, Saric M, Berkowitz RL. Midodrine increases blood pressure in hypotensive heart failure patients facilitating optimization of heart failure therapy leading to improved outcomes. <em>J Cardiac Fail<\/em> 2006;<strong>12<(6):S129. doi: https:\/\/doi.org\/10.1016\/j.cardfail.2006.06.448. <\/li>","DOI":"10.1016\/j.cardfail.2006.06.448"},{"key":"10.12890\/2022_003246_ref11","doi-asserted-by":"crossref","unstructured":"<li>Vijayaraghavan K, Little D, Mercer T, Querrey T, Wilmowski S, Win A, et al. Midodrine as a bridge to enable use of life enhancing therapies in chronic heart failure. <em>J Cardiac Fail<\/em> 2020;<strong>26<\/strong>(10):S59. https:\/\/doi.org\/10.1016\/j.cardfail.2020.09.175.<\/li>","DOI":"10.1016\/j.cardfail.2020.09.175"},{"key":"10.12890\/2022_003246_ref12","doi-asserted-by":"crossref","unstructured":"<li>Bergman SM. Hemodialysis in hypotensive heart failure using midodrine. <em>Am J Med Sci<\/em> 2009 Dec;<strong>338<\/strong>(6):470\u2013473. doi: 10.1097\/MAJ.0b013e3181b7efa7, PMID: 19875951.<\/li>","DOI":"10.1097\/MAJ.0b013e3181b7efa7"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3246\/3060","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3246\/3061","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3246\/3061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T11:35:23Z","timestamp":1755862523000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,18]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.12890\/2022_003246","relation":{"has-manifestation":[{"id-type":"other","id":"1-83-3246-g3060","asserted-by":"subject"},{"id-type":"other","id":"1-83-3246-g3061","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-83","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,18]]},"article-number":"1"}}