{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:08:01Z","timestamp":1790611681746,"version":"4.1.0"},"reference-count":18,"publisher":"SMC Media","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>A 57-year-old man presented to the outpatient clinic with tremor, palpitations, weight loss and fatigue 1 week after receiving the first dose of the Oxford-AstraZeneca SARS-CoV-2 vaccine (ChAdOx1 nCoV-19). Laboratory studies showed a suppressed TSH with elevated total and free T4. Thyroid peroxidase and thyroglobulin antibodies were elevated but thyrotropin receptor autoantibodies were indeterminate. Thyroid scintigraphy with technetium Tc-99m pertechnetate revealed increased diffuse, symmetric uptake. The patient was treated with thiamazole 15 mg three times a day and propranolol with resolution of his symptoms and normalization of his thyroid function tests until discontinuation of the antithyroid drug 6 months after symptom onset.<\/jats:p>","DOI":"10.12890\/2022_003275","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T03:34:15Z","timestamp":1649907255000},"source":"Crossref","is-referenced-by-count":5,"title":["A Case of Graves\u2019 Disease Following Vaccination with the Oxford-AstraZeneca SARS-CoV-2 Vaccine: Case Report and Review of the Literature"],"prefix":"10.12890","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9961-4667","authenticated-orcid":false,"given":"Dalia","family":"Cuenca","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3522-8406","authenticated-orcid":false,"given":"Mercedes","family":"Aguilar-Soto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, American British Cowdray Medical Center, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4748-9734","authenticated-orcid":false,"given":"Moises","family":"Mercado","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10397","published-online":{"date-parts":[[2022,4,14]]},"reference":[{"key":"10.12890\/2022_003275_ref1","unstructured":"<li>WHO. Weekly epidemiological update on COVID-19 - April 7th 2022. Available from: https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019\/situation-reports (accessed April 7 2022)<\/li>"},{"key":"10.12890\/2022_003275_ref2","doi-asserted-by":"crossref","unstructured":"<li>Liu Y, Sawalha AH, Lu Q. COVID-19 and autoimmune diseases. <em>Curr Opin Rheumatol<\/em> 2021;<strong>33<\/strong>(2):155\u2013162. doi:10.1097\/BOR.0000000000000776<\/li>","DOI":"10.1097\/BOR.0000000000000776"},{"key":"10.12890\/2022_003275_ref3","doi-asserted-by":"crossref","unstructured":"<li>Pujol A, G\u00f3mez LA, Gallegos C, Nicolau J, Sanch\u00eds P, Gonz\u00e1lez-Freire M, et al. Thyroid as a target of adjuvant autoimmunity\/inflammatory syndrome due to mRNA-based SARS-CoV2 vaccination: from Graves' disease to silent thyroiditis. <em>J Endocrinol Invest<\/em> 2022 Apr;<strong>45<\/strong>(4):875\u2013882. doi:10.1007\/s40618-021-01707-0<\/li>","DOI":"10.1007\/s40618-021-01707-0"},{"key":"10.12890\/2022_003275_ref4","doi-asserted-by":"crossref","unstructured":"<li>Chen Y, Xu Z, Wang P, Li XM, Shuai ZW, Ye DQ, et al. New-onset autoimmune phenomena post-COVID-19 vaccination. <em>Immunology<\/em> 2022 Apr;<strong>165<\/strong>(4):386\u2013401. doi:10.1111\/imm.13443<\/li>","DOI":"10.1111\/imm.13443"},{"key":"10.12890\/2022_003275_ref5","doi-asserted-by":"crossref","unstructured":"<li>Vera-Lastra O, Ordinola Navarro A, Cruz Domiguez MP, Medina G, S\u00e1nchez Valadez TI, Jara LJ. Two cases of Graves' disease following SARS-CoV-2 vaccination: an autoimmune\/inflammatory syndrome induced by adjuvants. <em>Thyroid<\/em> 2021;<strong>31<\/strong>(9):1436\u20131439. doi:10.1089\/thy.2021.0142<\/li>","DOI":"10.1089\/thy.2021.0142"},{"key":"10.12890\/2022_003275_ref6","doi-asserted-by":"crossref","unstructured":"<li>Zettinig G, Krebs M. Two further cases of Graves' disease following SARS-Cov-2 vaccination. <em>J Endocrinol Invest<\/em> 2022;<strong>45<\/strong>(1):227\u2013228. doi:10.1007\/s40618-021-01650-0<\/li>","DOI":"10.1007\/s40618-021-01650-0"},{"key":"10.12890\/2022_003275_ref7","doi-asserted-by":"crossref","unstructured":"<li>Hamouche W, El Soufi Y, Alzaraq S, Okafor BV, Zhang F, Paras C. A case report of new onset graves' disease induced by SARS-CoV-2 infection or vaccine?. <em>J Clin Transl Endocrinol Case Rep<\/em> 2022;<strong>23<\/strong>:100104. doi:10.1016\/j.jecr.2021.100104<\/li>","DOI":"10.1016\/j.jecr.2021.100104"},{"key":"10.12890\/2022_003275_ref8","doi-asserted-by":"crossref","unstructured":"<li>Pla Peris B, Merchante Alfaro A\u00c1, Maravall Royo FJ, Abell\u00e1n Galiana P, P\u00e9rez Naranjo S, Gonz\u00e1lez Boillos M. Thyrotoxicosis following SARS-COV-2 vaccination: a case series and discussion.<em>J Endocrinol Invest<\/em> 2022 Jan 11;1\u20137. doi:10.1007\/s40618-022-01739-0. Online ahead of print. <\/li>","DOI":"10.1007\/s40618-022-01739-0"},{"key":"10.12890\/2022_003275_ref9","doi-asserted-by":"crossref","unstructured":"<li>Weintraub MA, Ameer B, Sinha Gregory N. Graves disease following the SARS-CoV-2 vaccine: case series. <em>J Investig Med High Impact Case Rep<\/em> 2021;<strong>9<\/strong>:23247096211063356. doi:10.1177\/23247096211063356<\/li>","DOI":"10.1177\/23247096211063356"},{"key":"10.12890\/2022_003275_ref10","doi-asserted-by":"crossref","unstructured":"<li>Patrizio A, Ferrari SM, Antonelli A, Fallahi P. A case of Graves' disease and type 1 diabetes mellitus following SARS-CoV-2 vaccination. <em>J Autoimmun<\/em> 2021;<strong>125<\/strong>:102738. doi:10.1016\/j.jaut.2021.102738<\/li>","DOI":"10.1016\/j.jaut.2021.102738"},{"key":"10.12890\/2022_003275_ref11","doi-asserted-by":"crossref","unstructured":"<li>Sriphrapradang C, Shantavasinkul PC. Graves' disease following SARS-CoV-2 vaccination. <em>Endocrine<\/em> 2021;<strong>74<\/strong>(3):473\u2013474. doi:10.1007\/s12020-021-02902-y<\/li>","DOI":"10.1007\/s12020-021-02902-y"},{"key":"10.12890\/2022_003275_ref12","doi-asserted-by":"crossref","unstructured":"<li>Lui DTW, Lee KK, Lee CH, Lee ACH, Hung IFN, Tan KCB. Development of Graves' disease after SARS-CoV-2 mRNA vaccination: a case report and literature review. <em>Front Public Health<\/em> 2021;<strong>9<\/strong>:778964. doi:10.3389\/fpubh.2021.778964<\/li>","DOI":"10.3389\/fpubh.2021.778964"},{"key":"10.12890\/2022_003275_ref13","doi-asserted-by":"crossref","unstructured":"<li>Rubinstein TJ. Thyroid eye disease following COVID-19 vaccine in a patient with a history Graves' disease: a case report. <em>Ophthalmic Plast Reconstr Surg<\/em> 2021;<strong>37<\/strong>(6):e221\u2013e223. doi:10.1097\/IOP.0000000000002059<\/li>","DOI":"10.1097\/IOP.0000000000002059"},{"key":"10.12890\/2022_003275_ref14","doi-asserted-by":"crossref","unstructured":"<li>Goblirsch TJ, Paulson AE, Tashko G, Mekonnen AJ. Graves' disease following administration of second dose of SARS-CoV-2 vaccine. <em>BMJ Case Rep<\/em> 2021;<strong>14<\/strong>(12):e246432. doi:10.1136\/bcr-2021-246432<\/li>","DOI":"10.1136\/bcr-2021-246432"},{"key":"10.12890\/2022_003275_ref15","doi-asserted-by":"crossref","unstructured":"<li>Pierman G, Delgrange E, Jonas C. Recurrence of Graves' disease (a Th1-type cytokine disease) following SARS-CoV-2 mRNA vaccine administration: a simple coincidence?. <em>Eur J Case Rep Intern Med<\/em> 2021;<strong>8<\/strong>(9):002807. doi:10.12890\/2021_002807<\/li>","DOI":"10.12890\/2021_002807"},{"key":"10.12890\/2022_003275_ref16","doi-asserted-by":"crossref","unstructured":"<li>Sriphrapradang C. Aggravation of hyperthyroidism after heterologous prime-boost immunization with inactivated and adenovirus-vectored SARS-CoV-2 vaccine in a patient with Graves' disease. <em>Endocrine<\/em> 2021;<strong>74<\/strong>(2):226\u2013227. doi:10.1007\/s12020-021-02879-8<\/li>","DOI":"10.1007\/s12020-021-02879-8"},{"key":"10.12890\/2022_003275_ref17","doi-asserted-by":"crossref","unstructured":"<li>Vojdani A, Vojdani E, Kharrazian D. Reaction of human monoclonal antibodies to SARS-CoV-2 proteins with tissue antigens: implications for autoimmune diseases. <em>Front Immunol<\/em> 2021 Jan 19;<strong>11<\/strong>:617089. doi:10.3389\/fimmu.2020.617089<\/li>","DOI":"10.3389\/fimmu.2020.617089"},{"key":"10.12890\/2022_003275_ref18","doi-asserted-by":"crossref","unstructured":"<li>Teijaro JR, Farber DL. COVID-19 vaccines: modes of immune activation and future challenges. <em>Nat Rev Immunol<\/em> 2021;<strong>21<\/strong>(4):195\u2013197. doi:10.1038\/s41577-021-005<\/li>","DOI":"10.1038\/s41577-021-00526-x"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3275\/3094","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3275\/3095","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3275\/3095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T10:49:55Z","timestamp":1755859795000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,14]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.12890\/2022_003275","relation":{"has-manifestation":[{"id-type":"other","id":"1-84-3275-g3094","asserted-by":"subject"},{"id-type":"other","id":"1-84-3275-g3095","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-84","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,14]]},"article-number":"6"}}