{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:06:49Z","timestamp":1755907609447,"version":"3.44.0"},"reference-count":5,"publisher":"SMC Media","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer-related death in the USA. Primary signet ring cell carcinoma (SRCC) of the colon and rectum is extremely rare with a reported incidence of less than 1%. Here we present the case of a 41-year-old man who presented with abdominal pain, severe microcytic anaemia and a negative faecal occult blood test (FOBT). A CT scan of the abdomen revealed thickening of the terminal ileum and proximal right colon with extensive lymphadenopathy and a fistula tract extending from the terminal ileum to the right buttock. Endoscopic features like cobblestoning of the ileocolic junction along with elevated blood and stool inflammatory markers raised suspicion of Crohn\u2019s disease (CD). However, histopathological study surprisingly revealed primary colorectal signet cell carcinoma (PCRSCC) with no evidence of CD. Cases of simultaneous PCRSCC and CD have been reported, but no clear association has been established. Our case is unique in that it presented with classic clinical features of CD, but PCRSCC without any histological evidence of underlying CD was found on histology.<\/jats:p>","DOI":"10.12890\/2022_003294","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T04:07:26Z","timestamp":1651550846000},"source":"Crossref","is-referenced-by-count":0,"title":["A Signet Cell Carcinoma of the Ileum: A Rare Differential Diagnosis of Intestinal Pathology with Fistula Mimicking Crohn\u2019s Disease"],"prefix":"10.12890","volume":"9","author":[{"given":"Gaurav","family":"Mohan","sequence":"additional","affiliation":[{"name":"Monmouth Medical Center, Long Branch, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harshil","family":"Fichadiya","sequence":"additional","affiliation":[{"name":"Monmouth Medical Center, Long Branch, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darby","family":"Olex-Memoli","sequence":"additional","affiliation":[{"name":"Rutgers Robert Wood Johnson Medical School, Brunswick, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Krishna","sequence":"additional","affiliation":[{"name":"Rutgers Robert Wood Johnson Medical School, Brunswick, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doatrang","family":"Du","sequence":"additional","affiliation":[{"name":"Monmouth Medical Center, Long Branch, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buket","family":"Bagchi","sequence":"additional","affiliation":[{"name":"Monmouth Medical Center, Long Branch, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Rashidbaigi","sequence":"additional","affiliation":[{"name":"Monmouth Medical Center, Long Branch, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2022,4,7]]},"reference":[{"key":"10.12890\/2022_003294_ref1","doi-asserted-by":"crossref","unstructured":"<li>M\u00e1rmol I, S\u00e1nchez-de-Diego C, Pradilla Dieste A, Cerrada E, Rodriguez Yoldi MJ. Colorectal carcinoma: a general overview and future perspectives in colorectal cancer. <em>Int J Mol Sci<\/em> 2017;<strong>18<\/strong>(1):197. doi: 10.3390\/ijms18010197<\/li>","DOI":"10.3390\/ijms18010197"},{"key":"10.12890\/2022_003294_ref2","doi-asserted-by":"crossref","unstructured":"<li>An Y, Zhou J, Lin G, Wu H, Cong L, Li Y, et al. Clinicopathological and molecular characteristics of colorectal signet ring cell carcinoma: a review. <em>Pathol Oncol Res<\/em> 2021;<strong>27<\/strong>:1609859. doi: 10.3389\/pore.2021.1609859<\/li>","DOI":"10.3389\/pore.2021.1609859"},{"key":"10.12890\/2022_003294_ref3","doi-asserted-by":"crossref","unstructured":"<li>Belli S, Aytac HO, Karagulle E, Yabanoglu H, Kayaselcuk F, Yildirim S. Outcomes of surgical treatment of primary signet ring cell carcinoma of the colon and rectum: 22 cases reviewed with literature. <em>Int Surg<\/em> 2014;<strong>99<\/strong>(6):691\u2013698. doi: 10.9738\/INTSURG-D-14-00067.1<\/li>","DOI":"10.9738\/INTSURG-D-14-00067.1"},{"key":"10.12890\/2022_003294_ref4","unstructured":"<li>Makino T, Tsujinaka T, Mishima H, Ikenaga M, Sawamura T, Nakamori S, et al. Primary signet-ring cell carcinoma of the colon and rectum: report of eight cases and review of 154 Japanese cases. <em>Hepatogastroenterology<\/em> 2006 Nov-Dec;<strong>53<\/strong>(72):845\u2013849. PMID: 17153438.<\/li>"},{"key":"10.12890\/2022_003294_ref5","doi-asserted-by":"crossref","unstructured":"<li>Carvalho JR, Tavares J, Goulart I, Moura dos Santos P, Vitorino E, Ferreira C, et al. Signet ring cell carcinoma, ileal Crohn disease or both? - A case of diagnostic challenge. <em>GE Port J Gastroenterol<\/em> 2018;<strong>25<\/strong>:47\u201351. doi: 10.1159\/000479590<\/li>","DOI":"10.1159\/000479590"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3294\/3088","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3294\/3089","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3294\/3089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T10:50:07Z","timestamp":1755859807000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,7]]},"references-count":5,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.12890\/2022_003294","relation":{"has-manifestation":[{"id-type":"other","id":"1-84-3294-g3088","asserted-by":"subject"},{"id-type":"other","id":"1-84-3294-g3089","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-84","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2022,4,7]]},"article-number":"9"}}