{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:36:10Z","timestamp":1769506570025,"version":"3.49.0"},"reference-count":20,"publisher":"SMC Media","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Suboptimal nutrition can lead to deficiencies in micronutrients such as ascorbic acid (vitamin C), which can present with catastrophic neurological sequalae. Deficiencies of vitamin C, vitamin B3 (niacin) and zinc levels contribute to reduced bone density. Vitamin C associated vertebral fractures although rare in adults, are still treatable if diagnosed early with a thorough clinical and nutritional history and early supplementation.\u00a0 Radiological clues suggestive of scurvy induced vertebral fractures can be diagnosed on plain X-ray and MRI spine imaging.<\/jats:p>","DOI":"10.12890\/2022_003359","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T10:15:50Z","timestamp":1669025750000},"source":"Crossref","is-referenced-by-count":1,"title":["Scurvy: A case report of rare orthopaedic complications associated with multi-nutritional deficiencies"],"prefix":"10.12890","volume":"9","author":[{"given":"Melissa","family":"Carroll","sequence":"first","affiliation":[{"name":"Royal Melbourne HospitalThe Royal Darwin Hospital, Tiwi, Northern Territory, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Yoon","sequence":"first","affiliation":[{"name":"The Royal Darwin Hospital, Tiwi, Northern Territory, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Elliott","sequence":"first","affiliation":[{"name":"The Royal Darwin Hospital, Tiwi, Northern Territory, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2022,11,17]]},"reference":[{"key":"10.12890\/2022_003359_ref1","unstructured":"<li>Hercberg S, Preziosi P, Galan P, Devanlay M, Keller H, Bourgeois C, et al. Vitamin status of a healthy French population: dietary intakes and biochemical markers.<em>Int J Vitam Nutr Res<\/em> 1994;<strong>64<\/strong>:220-232.<\/li>"},{"key":"10.12890\/2022_003359_ref2","doi-asserted-by":"crossref","unstructured":"<li>Hampl JS, Taylor CA, Johnston CS. Vitamin C deficiency and depletion in the United States: the Third National Health and Nutrition Examination Survey, 1988 to 1994.<em>Am J Public Health<\/em> 2004;<strong>94<\/strong>:870-875. doi:10.2105\/ajph.94.5.870.<\/li>","DOI":"10.2105\/AJPH.94.5.870"},{"key":"10.12890\/2022_003359_ref3","doi-asserted-by":"crossref","unstructured":"<li>Schleicher RL, Carroll MD, Ford ES, Lacher DA. Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003\u20132004 National Health and Nutrition Examination Survey (NHANES). <em>Am J Clin Nutr<\/em> 2009;<strong>90<\/strong>:1252-1263. doi:10.3945\/ajcn.2008.27016.<\/li>","DOI":"10.3945\/ajcn.2008.27016"},{"key":"10.12890\/2022_003359_ref4","doi-asserted-by":"crossref","unstructured":"<li>Lipner S. A classic case of scurvy. <em>Lancet<\/em> 2018;<strong>392<\/strong>(10145):431. doi:10.1016\/S0140-6736(18)31491-0.<\/li>","DOI":"10.1016\/S0140-6736(18)31491-0"},{"key":"10.12890\/2022_003359_ref5","doi-asserted-by":"crossref","unstructured":"<li>Szterenlicht YM, Jarjoui A, Kurd R, Levy L, Munter G. A peculiar case of purpura. <em>Am J Med<\/em> 2019;<strong>132<\/strong>:934-935. doi:10.1016\/j.amjmed.2019.02.047.<\/li>","DOI":"10.1016\/j.amjmed.2019.02.047"},{"key":"10.12890\/2022_003359_ref6","doi-asserted-by":"crossref","unstructured":"<li>Bonsall A. Never surprise a patient with scurvy. <em>Int J Dermatol<\/em> 2017;<strong>56<\/strong>:1488-1489. doi:https:\/\/doi.org\/10.1111\/ijd.13723.<\/li>","DOI":"10.1111\/ijd.13723"},{"key":"10.12890\/2022_003359_ref7","doi-asserted-by":"crossref","unstructured":"<li>Colacci M, Gold WL, Shah R. Modern-day scurvy. <em>CMAJ<\/em> 2020;<strong>192<\/strong>:E96. doi:10.1503\/cmaj.190934.<\/li>","DOI":"10.1503\/cmaj.190934"},{"key":"10.12890\/2022_003359_ref8","doi-asserted-by":"crossref","unstructured":"<li>Joshi R, Gustas-French CN, Fanburg-Smith JC, Helm KF, Flemming D. Scurvy: a rare case in an adult. <em>Skeletal Radiol.<\/em> 2019;<strong>48<\/strong>:977-984. doi:10.1007\/s00256-018-3069-3<\/li>","DOI":"10.1007\/s00256-018-3069-3"},{"key":"10.12890\/2022_003359_ref9","doi-asserted-by":"crossref","unstructured":"<li>Peterkofsky B, Gosiewska A, Kipp DE, Shah V, Wilson S. Circulating insulin-like growth factor binding proteins (IGFBPs) 1 and 2 induced in vitamin C-deficient or fasted guinea pigs inhibit IGF-I action in cultured cells. <em>Growth Factors<\/em> 1994;<strong>10<\/strong>:229-241. doi:10.3109\/08977199409010989.<\/li>","DOI":"10.3109\/08977199409010989"},{"key":"10.12890\/2022_003359_ref10","doi-asserted-by":"crossref","unstructured":"<li>Hodges RE, Hood J, Canham JE, Sauberlich HE, Baker EM. Clinical manifestations of ascorbic acid deficiency in man. <em>Am J Clin Nutr<\/em> 1971;<strong>24<\/strong>:432-443. doi:10.1093\/ajcn\/24.4.432.<\/li>","DOI":"10.1093\/ajcn\/24.4.432"},{"key":"10.12890\/2022_003359_ref11","doi-asserted-by":"crossref","unstructured":"<li>Chen G-C, Lu D-B, Pang Z, Liu Q-F. Vitamin C intake, circulating vitamin C and risk of stroke: a meta-analysis of prospective studies. <em>J Am Heart Assoc<\/em>. 2013;<strong>2<\/strong>. doi:10.1161\/JAHA.113.000329.<\/li>","DOI":"10.1161\/JAHA.113.000329"},{"key":"10.12890\/2022_003359_ref12","doi-asserted-by":"crossref","unstructured":"<li>Vannier S, Thomas R, Jean-christophe F, Pinel JF, Verin M. Vitamin C depletion is spontaneous intracerebral hemorrhage risk factor. (S25.005). <em>Neurology<\/em> 2014;<strong>82<\/strong>(10 Supplement). https:\/\/n.neurology.org\/content\/82\/10_Supplement\/S25.005. Accessed 8 June 2020.<\/li>","DOI":"10.1212\/WNL.82.10_supplement.S25.005"},{"key":"10.12890\/2022_003359_ref13","doi-asserted-by":"crossref","unstructured":"<li>Nyyss\u00f6nen K, Parviainen MT, Salonen R, Tuomilehto J, Salonen JT. Vitamin C deficiency and risk of myocardial infarction: prospective population study of men from eastern Finland. <em>BMJ<\/em> 1997;<strong>314<\/strong>:634-638. doi:10.1136\/bmj.314.7081.634.<\/li>","DOI":"10.1136\/bmj.314.7081.634"},{"key":"10.12890\/2022_003359_ref14","doi-asserted-by":"crossref","unstructured":"<li>Padayatty SJ, Levine M. Vitamin C and myocardial infarction: the heart of the matter. <em>Am J Clin Nutr<\/em> 2000;<strong>71<\/strong>:1027-1028. doi:10.1093\/ajcn\/71.5.1027.<\/li>","DOI":"10.1093\/ajcn\/71.5.1027"},{"key":"10.12890\/2022_003359_ref15","doi-asserted-by":"crossref","unstructured":"<li>Simon JA, Hudes ES. Relation of ascorbic acid to bone mineral density and self-reported fractures among US adults. <em>Am J Epidemiol<\/em> 2001;<strong>154<\/strong>:427-433. doi:10.1093\/aje\/154.5.427.<\/li>","DOI":"10.1093\/aje\/154.5.427"},{"key":"10.12890\/2022_003359_ref16","doi-asserted-by":"crossref","unstructured":"<li>Fain O. Musculoskeletal manifestations of scurvy. <em>Jt Bone Spine<\/em> 2005;<strong>72<\/strong>:124-128. doi:10.1016\/j.jbspin.2004.01.007.<\/li>","DOI":"10.1016\/j.jbspin.2004.01.007"},{"key":"10.12890\/2022_003359_ref17","doi-asserted-by":"crossref","unstructured":"<li>Uda K, Goto M, Nigo A, Kono T. Early diagnosis of scurvy based on radiology and dietary history. <em>Pediatr Int<\/em> 2017;<strong>59<\/strong>:357-358. doi:10.1111\/ped.13183.<\/li>","DOI":"10.1111\/ped.13183"},{"key":"10.12890\/2022_003359_ref18","unstructured":"<li>Seftel HC, Malkin C, Schmaman A, Abrahams C, Lynch SR, Charlton RW, et al. Osteoporosis, scurvy and siderosis in Johannesburg Bantu. <em>Science<\/em> 1966;<strong>936<\/strong>(March):1964-1965.<\/li>"},{"key":"10.12890\/2022_003359_ref19","doi-asserted-by":"crossref","unstructured":"<li>Joffe N. Some radiological aspects of scurvy in the adult. <em>Brit J Radiol<\/em> 1961;<strong>34<\/strong>:429-437. doi:10.1259\/0007-1285-34-403-429.<\/li>","DOI":"10.1259\/0007-1285-34-403-429"},{"key":"10.12890\/2022_003359_ref20","doi-asserted-by":"crossref","unstructured":"<li>Howland WJ, Curry JL, Buffington CB. Fulcrum fractures of the lumbar spine: transverse fracture induced by an improperly placed seat belt. <em>JAMA<\/em> 1965;<strong>193<\/strong>:240-241. doi:10.1001\/jama.1965.03090030062025<\/li>","DOI":"10.1001\/jama.1965.03090030062025"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3359\/3296","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3359\/3297","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3359\/3297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T13:49:05Z","timestamp":1755784145000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,17]]},"references-count":20,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.12890\/2022_003359","relation":{"has-manifestation":[{"id-type":"other","id":"1-92-3359-g3296","asserted-by":"subject"},{"id-type":"other","id":"1-92-3359-g3297","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-92","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,17]]}}}